Poly-4-Hydroxybutyrate Scaffold in Rhytidectomy

NCT ID: NCT07132892

Last Updated: 2026-01-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Clinical Phase

NA

Total Enrollment

6 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-12-01

Study Completion Date

2027-12-31

Brief Summary

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The study is being conducted to objectively assess tissue changes following the use of P4HB in rhytidectomy to understand how the utilization of the surgical mesh may affect tissue mechanical strength and elasticity, wound healing, and scar formation dynamics.

Detailed Description

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This is a prospective study designed to follow six (6) qualified and consenting adults, 18-80 years of age scheduled for an elective rhytidectomy with the Principal Investigator (PI). Subjects will be evaluated at baseline, month 1, month 6 and month 12. The effects of the study device will be analyzed at all follow up visits through clinical/3D photography, non-invasive skin assessments and subject/physician questionnaires. The PI will be collecting tissue samples during their surgical procedure, month 6 and month 12 visits. Histopathology will be completed on the collected sample to assess changes of the tissue after the subjects rhytidectomy.

Conditions

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Tissue Adhesion

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Study procedure will be used to assess changes of the tissue.
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Healthy Participants

Healthy subjects who received an elective rhytidectomy

The GalaFLEX LITE is a surgical mesh scaffold composed of poly-4-hydroxybutyrate (P4HB) developed to prolong strength retention and reinforce soft tissue in patients undergoing plastic and reconstructive surgery.

Group Type EXPERIMENTAL

Galaflex Lite Scaffold

Intervention Type DEVICE

The GalaFLEX LITE is a surgical mesh scaffold composed of poly-4-hydroxybutyrate (P4HB) developed to prolong strength retention and reinforce soft tissue in patients undergoing plastic and reconstructive surgery.

Interventions

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Galaflex Lite Scaffold

The GalaFLEX LITE is a surgical mesh scaffold composed of poly-4-hydroxybutyrate (P4HB) developed to prolong strength retention and reinforce soft tissue in patients undergoing plastic and reconstructive surgery.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Healthy adults 18-80 years of age
2. Planned/scheduled rhytidectomy at UT Southwestern with the study doctor
3. Willing to return for follow up visits and undergo study evaluations

Exclusion Criteria

1. Individuals diagnosed with known reaction to device material (tetracycline hydrochloride, kanamycin sulfate, etc)
2. Individuals who have significant scarring on the test area
3. Individuals with a disorder to negatively affect wound healing
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Jeffrey M. Kenkel

OTHER

Sponsor Role lead

Responsible Party

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Jeffrey M. Kenkel

Chairman and Professor

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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University of Texas Southwestern Medical Center

Dallas, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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STU20251603

Identifier Type: -

Identifier Source: org_study_id

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