Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
122 participants
INTERVENTIONAL
2024-04-07
2025-04-07
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
DIAGNOSTIC
TRIPLE
Study Groups
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Ibuprofen 400 mg
Participants will receive a single oral dose of 400 mg ibuprofen. Cold test and electric pulp test (EPT) will be performed on a tooth with symptomatic irreversible pulpitis and on a contralateral healthy tooth before drug administration and 30 minutes after ingestion.
Ibuprofen 400 mg (if necessary)
Single oral dose of 400 mg ibuprofen administered in a blinded capsule. Prior to dosing, baseline pulpal sensibility tests (cold test with Endo-Ice and Electric Pulp Test) and pain rating (VAS) will be recorded on a contralateral healthy tooth and the target tooth with symptomatic irreversible pulpitis. The drug is given orally and tests are repeated 30 minutes after ingestion. Participants are monitored for adverse effects. Participants who cannot take NSAIDs are excluded
Paracetamol 500 mg
Participants will receive a single oral dose of 500 mg paracetamol. Cold test and electric pulp test (EPT) will be performed on a tooth with symptomatic irreversible pulpitis and on a contralateral healthy tooth before drug administration and 30 minutes after ingestion.
Paracetamol 500 mg
A single oral dose of 500 mg paracetamol administered in a blinded capsule. Baseline pulpal sensibility testing (cold test with Endo-Ice and Electric Pulp Test) and pain level assessment using a Visual Analogue Scale (VAS) will be performed on both the tooth with symptomatic irreversible pulpitis and a contralateral healthy tooth prior to administration. The same tests will be repeated 30 minutes after ingestion to evaluate any masking effect on test results.
Interventions
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Ibuprofen 400 mg (if necessary)
Single oral dose of 400 mg ibuprofen administered in a blinded capsule. Prior to dosing, baseline pulpal sensibility tests (cold test with Endo-Ice and Electric Pulp Test) and pain rating (VAS) will be recorded on a contralateral healthy tooth and the target tooth with symptomatic irreversible pulpitis. The drug is given orally and tests are repeated 30 minutes after ingestion. Participants are monitored for adverse effects. Participants who cannot take NSAIDs are excluded
Paracetamol 500 mg
A single oral dose of 500 mg paracetamol administered in a blinded capsule. Baseline pulpal sensibility testing (cold test with Endo-Ice and Electric Pulp Test) and pain level assessment using a Visual Analogue Scale (VAS) will be performed on both the tooth with symptomatic irreversible pulpitis and a contralateral healthy tooth prior to administration. The same tests will be repeated 30 minutes after ingestion to evaluate any masking effect on test results.
Eligibility Criteria
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Inclusion Criteria
Patients with prolonged pain in response to the cold test with Endo-Ice
Patients who had not used any analgesics or CNS depressant during last 6 hours
Males and females aged 18-40
Exclusion Criteria
who could not take paracetamol and ibuprofen
whose teeth did not respond to the cold test
with toothache due to periapical disease
18 Years
65 Years
ALL
No
Sponsors
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HITEC-Institute of Medical Sciences
OTHER
Responsible Party
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Dr Kinza Iftikhar
Dr Kinza
Principal Investigators
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Dr Kinza Iftikhar, BDS
Role: PRINCIPAL_INVESTIGATOR
HITEC-Institute of Medical Sciences
Locations
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Hitec Ims
Rawalpindi, Punjab Province, Pakistan
Countries
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Related Links
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Related Info
Other Identifiers
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Dr Kinza Iftikhar
Identifier Type: -
Identifier Source: org_study_id
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