Thermal Radiofrequency Neurolysis Versus Alcoholic Neurolysis of the Genicular Nerves for Treatment of Chronic Knee Pain in Advanced Knee Osteoarthritis
NCT ID: NCT07125768
Last Updated: 2025-08-15
Study Results
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Basic Information
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COMPLETED
NA
70 participants
INTERVENTIONAL
2024-07-01
2025-07-01
Brief Summary
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Detailed Description
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Chronic pain of knee osteoarthritis is a common clinical symptom leading to restricted movement, disability, psychological distress, and impaired quality of life.
The targeted genicular nerves are those that had a close topographic relationship with the bone cortical surfaces, such as the femoral epicondyles (Superior medial \[SM\] and Superior lateral \[SL\] genicular nerves) and the medial tibial epicondyle (Inferior medial \[IM\] genicular nerve).
Nerve ablation causes iatrogenic neural degeneration, aiming only for sensory or sympathetic denervation without motor deficits. The nerve ablation methods currently available are performed by either thermal ablation using radiofrequency or chemical ablation using alcohol or phenol.
Chemical neurolysis techniques can be an effective method to accomplish a larger, more thorough lesioning than radiofrequency ablation and are capable of covering the anatomical variability of genicular nerves, so ensuring a better success rate and outcome with less cost and less logistic support.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Group I
Patients received C-arm guided neurolysis of superior medial \[SM\], superior lateral \[SL\], and inferior medial \[IM\] genicular nerves by thermal radiofrequency.
Thermal Radiofrequency Neurolysis
Patients received C-arm guided neurolysis of superior medial \[SM\], superior lateral \[SL\], and inferior medial \[IM\] genicular nerves by thermal radiofrequency.
Group II
Patients received C-arm guided injection of each of the three genicular nerves with 1 ml of a solution containing 70% alcohol in 0.25% lidocaine.
Alcoholic Neurolysis
Patients received C-arm guided injection of each of the three genicular nerves with 1 ml of a solution containing 70% alcohol in 0.25% lidocaine.
Interventions
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Thermal Radiofrequency Neurolysis
Patients received C-arm guided neurolysis of superior medial \[SM\], superior lateral \[SL\], and inferior medial \[IM\] genicular nerves by thermal radiofrequency.
Alcoholic Neurolysis
Patients received C-arm guided injection of each of the three genicular nerves with 1 ml of a solution containing 70% alcohol in 0.25% lidocaine.
Eligibility Criteria
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Inclusion Criteria
* Both sexes.
* Stage 3 and 4 knee osteoarthritis in patients who aren't responding to pharmacological treatment and aren't good candidates for knee replacement surgery.
Exclusion Criteria
* Bleeding disorders.
* Infection at or near the injection site.
* Presence of a pacemaker or defibrillator.
* Acute knee injury.
* Unstable knee joint.
40 Years
60 Years
ALL
No
Sponsors
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Tanta University
OTHER
Responsible Party
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Hesham Mahmoud Elsayed Eldamhogy
Resident of Anesthesiology, Surgical Intensive Care and Pain Management Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Locations
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Tanta University
Tanta, El-Gharbia, Egypt
Countries
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Other Identifiers
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36264MS603/5/24
Identifier Type: -
Identifier Source: org_study_id
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