Transcutaneous Pulsed Radiofrequency Application Plus Genicular Nerve Block Versus Intraarticular Hyaluronic Acid Injection for Management of Chronic Pain in Knee Osteoarthritis.
NCT ID: NCT06710782
Last Updated: 2024-11-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
80 participants
INTERVENTIONAL
2023-08-01
2024-07-01
Brief Summary
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Detailed Description
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As an alternative approach, radiofrequency treatment modalities on the knee joint have been used to reduce knee pain due to osteoarthritis. Genicular nerve block (GNB) is a recently developed therapeutic option for knee osteoarthritis. that targets the three sensory nerves of the knee: superior lateral, superior medial and inferior medial genicular nerve, to inhibit pain transmission to the central nervous system.
Early osteoarthritis. treatment combines non pharmacological techniques with oral pharmacological therapies, intraarticular injections (IAI) of hyaluronic acid (HA), corticosteroid with local anesthetic or platelet-rich plasma (PRP) are used in progressive or very symptomatic stage. Intraarticular injections (IAI) is considered one of first-line treatments in recent studies as it is effective in decreasing pain and safer than oral pharmacological therapies.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Hyaluronic Acid group
Patients underwent intra-articular hyaluronic acid injection.
Hyaluronic acid
Patients underwent intra-articular hyaluronic acid injection.
Transcutaneous pulsed radiofrequency group
Patients underwent transcutaneous pulsed radiofrequency application plus genicular nerve block.
Transcutaneous pulsed radiofrequency
Patients underwent transcutaneous pulsed radiofrequency application plus genicular nerve block.
Interventions
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Hyaluronic acid
Patients underwent intra-articular hyaluronic acid injection.
Transcutaneous pulsed radiofrequency
Patients underwent transcutaneous pulsed radiofrequency application plus genicular nerve block.
Eligibility Criteria
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Inclusion Criteria
* Both sexes
* American Society of Anesthesiologists (ASA)physical status I and II.
* Patients radiologically proven symptomatic knee joint osteoarthritis not responding to medical treatment.
* Patients with knee pain of moderate or greater intensity on most or all days for ≥ 3 months, showing significant radiological osteoarthritis (Kellgren-Lawrence grade 1 to 3).
Radiological severity was assessed using the Kellgrenand Lawrence global scale as follow: Grade 0; means absence of radiological finding; grade 1: suspected narrowing of joint space; grade 2 refers to osteophytes and possible narrowing; grade 3 is defined as multiple os-teophytes, definite narrowing of joint space and grade 4 comprises large osteophytes, marked narrowing of joint space.
Exclusion Criteria
* Patients who show improvement on medical treatment, patients on an oral, topical, or intra-articular steroid during the 4 weeks before the study; patients with an oral, topical, or suppository non-steroidal anti-inflammatory drugs within 2 weeks before the study.
* Patients having secondary knee osteoarthritis.
* Patients with severe osteoarthritis.(K/L grade \>3) in a location other than the knee joint.
* Patients with rheumatoid arthritis.
* Patients with joint replacement surgery in either knee and/or a hip.
* Patients with meniscal tear, ligament injury, bursitis, and popliteal cyst and blood investigations suggestive of any infection.
* Morbid obese patients (body mass index (BMI) of \>40 kg/m2)
* Infection at site of injection.
* Bleeding diathesis and coagulopathy.
40 Years
ALL
No
Sponsors
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Tanta University
OTHER
Responsible Party
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Omar Hashem Mohammed
Resident of Anesthesiology,Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.
Locations
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Tanta University
Tanta, ElGharbia, Egypt
Countries
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Other Identifiers
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36264MS262/7/23
Identifier Type: -
Identifier Source: org_study_id