Placental Characteristics Within Monochorionic Twin Pregnancies

NCT ID: NCT07124312

Last Updated: 2025-08-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

65 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-12-12

Study Completion Date

2027-02-01

Brief Summary

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This prospective study aims to collate a comprehensive database of all main monochorionic twin groups to enable comparisons to be made within each twin group and additionally between each group with regards to several placental characteristics, whilst understanding their impact on several fetal outcomes. This study aims to provide new insights in to how the placental architecture influences pregnancy care within the UK pregnancy cohort. Results of this study may impact how clinicians conduct antenatal surveillance for these anatomical placental factors.

Patients of both uncomplicated and complication monochorionic twin groups will be consented at a single site and recruited during the antenatal period. Following delivery the placenta will then be analysed macroscopically and assessed for several anatomical features. This will be compared with the antenatal complications and perinatal outcomes for the respective twin.

Detailed Description

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Conditions

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Placenta Monochorionic Twins Anatomy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Uncomplicated monochorionic twins

Monochorionic twins which do not develop any complications during the antenatal period

No interventions assigned to this group

Complicated monochorionic twins

Monochorionic twins which develop any type of complication during the antenatal period such as TTTS, sIUGR and TAPS.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

• All consecutive placentas of monochorionic twin pregnancies whereby the placenta is transferred to the pathology department for analysis.

Exclusion Criteria

* Singleton, dichorionic and higher order pregnancies (e.g. triplet).
* Fetus with known major congenital anomalies or aneuploidy
Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Birmingham Women's NHS Foundation Trust

OTHER_GOV

Sponsor Role lead

Responsible Party

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Jack Hamer

Clinical research fellow

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jack Hamer, MBChB

Role: PRINCIPAL_INVESTIGATOR

Birmingham Women's and Children's NHS Foundation Trust

Locations

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Birmingham Women's and Children's NHS Foundation Trust

Birmingham, West Midlands, United Kingdom

Site Status RECRUITING

Countries

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United Kingdom

Central Contacts

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Jack Hamer, MBChB

Role: CONTACT

0121 472 1377

Facility Contacts

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Jack Hamer

Role: primary

0121 472 1377

Other Identifiers

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24/BW/MAT/NO/852

Identifier Type: -

Identifier Source: org_study_id

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