EVALUATION OF SALIVA AS LIQUID BIOPSY FOR EARLY DETECTION OF ORAL CANCER IN PATIENTS WITH ORAL-SUBMUCOUS FIBROSIS (OSMF)
NCT ID: NCT07122128
Last Updated: 2025-08-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
1000 participants
OBSERVATIONAL
2021-06-01
2026-06-30
Brief Summary
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Patients often develop a pre-malignant condition, oral submucous fibrosis, resulting in limited mouth opening. Thus, patients are diagnosed at an advanced level and poor survival. Therefore, saliva appears a potential mode of evaluation for early detection. This project aims to evaluate salivary cells, genes and biochemistry of the saliva among health volunteers and compare it with that of the patients with oral submucous fibrosis and oral cancer.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Normal healthy volunteers
oral examination will be done, those without any oral infection, oral submucous fibrosis or cancer will be included in health volunteer group
saliva a a diagnostic tool for early detection of oral cancer
Three groups will be compared on the basis of cytology, genes and biochemical analysis
oral submucous fibrosis
Patients with oral submucous fibrosis both with and without limited mouth opening
saliva a a diagnostic tool for early detection of oral cancer
Three groups will be compared on the basis of cytology, genes and biochemical analysis
oral cancer patients
patients with biopsy proven oral cancer
saliva a a diagnostic tool for early detection of oral cancer
Three groups will be compared on the basis of cytology, genes and biochemical analysis
Interventions
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saliva a a diagnostic tool for early detection of oral cancer
Three groups will be compared on the basis of cytology, genes and biochemical analysis
Eligibility Criteria
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Inclusion Criteria
* patients with oral submucous fibrosis
* patients with biopsy proven oral cancer
Exclusion Criteria
ALL
Yes
Sponsors
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Sindh Higher Education Commission
UNKNOWN
Liaquat University of Medical & Health Sciences
OTHER
Responsible Party
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Prof. Binafsha Manzoor Syed
Professor
Principal Investigators
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Binafsha Manzoor Prof. Syed, PhD
Role: PRINCIPAL_INVESTIGATOR
Liaquat University of Medical and Health Sciences
Locations
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Medical Research Center
Jāmshoro, Sinch, Pakistan
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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Sal001
Identifier Type: OTHER
Identifier Source: secondary_id
SalivaP01
Identifier Type: -
Identifier Source: org_study_id
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