Pulpotomy Materials in Primary Molars

NCT ID: NCT07120321

Last Updated: 2025-08-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

22 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-01-01

Study Completion Date

2025-07-01

Brief Summary

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This randomized clinical trial aims to compare four different materials used in a dental procedure called pulpotomy. Pulpotomy is commonly performed on primary molars (back teeth in children) to treat deep cavities and preserve the tooth. Children aged 4 to 7 who need this procedure will receive one of four materials: Mineral Trioxide Aggregate (MTA), Biodentine, Ferric Sulfate, or Sodium Hypochlorite gel. The treated teeth will be checked at 6 and 12 months to evaluate the success of each material. The goal is to identify the most effective and reliable material for pulpotomy in primary molars.

Detailed Description

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Vital pulpotomy is a conservative and widely used treatment to maintain the function of primary molars affected by deep carious lesions. The choice of pulpotomy medicament plays a significant role in the long-term success of the procedure.

This randomized clinical trial is designed to compare the clinical and radiographic success rates of four pulpotomy agents: Mineral Trioxide Aggregate (MTA), Biodentine, Ferric Sulfate (FS), and Sodium Hypochlorite gel (NaOCl gel).

A total of 88 mandibular second primary molars in children aged 4 to 7 years will be included. After coronal pulp removal, one of the four materials will be applied to the pulp tissue. All treated teeth will be restored with stainless steel crowns. Follow-up evaluations will be performed at 6 and 12 months to assess the clinical and radiographic success of each material.

The findings from this study are expected to help determine the most effective and reliable pulpotomy material for use in pediatric dentistry.

Conditions

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Dental Caries Pulpitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

This is a randomized controlled clinical trial with a split-mouth design where each participant receives multiple interventions on different teeth.
Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors
Outcome assessors are blinded to the treatment allocation to reduce assessment bias. Participants, care providers, and investigators are aware of the assigned treatments.

Study Groups

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MTA Group

Primary molars treated with Mineral Trioxide Aggregate (MTA) as the pulpotomy medicament.

Group Type EXPERIMENTAL

Mineral Trioxide Aggregate (MTA)

Intervention Type DRUG

Used as the capping agent after coronal pulp removal in primary molars.

Biodentine Group

Primary molars treated with Biodentine as the pulpotomy medicament.

Group Type EXPERIMENTAL

Biodentine

Intervention Type DRUG

Used as a bioactive pulpotomy agent following coronal pulp amputation.

Ferric Sulfate Group

Primary molars treated with 15.5% Ferric Sulfate as the pulpotomy medicament.

Group Type EXPERIMENTAL

Ferric Sulfate

Intervention Type DRUG

15.5% Ferric Sulfate applied to pulp stumps for 15 seconds during pulpotomy procedure.

Sodium Hypochlorite Gel Group

Primary molars treated with 5% Sodium Hypochlorite gel as the pulpotomy medicament.

Group Type EXPERIMENTAL

Sodium hypochlorite gel application

Intervention Type DRUG

5% NaOCl gel applied to pulp tissue during pulpotomy for its hemostatic and disinfectant effects.

Interventions

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Mineral Trioxide Aggregate (MTA)

Used as the capping agent after coronal pulp removal in primary molars.

Intervention Type DRUG

Biodentine

Used as a bioactive pulpotomy agent following coronal pulp amputation.

Intervention Type DRUG

Ferric Sulfate

15.5% Ferric Sulfate applied to pulp stumps for 15 seconds during pulpotomy procedure.

Intervention Type DRUG

Sodium hypochlorite gel application

5% NaOCl gel applied to pulp tissue during pulpotomy for its hemostatic and disinfectant effects.

Intervention Type DRUG

Other Intervention Names

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MTA; ProRoot MTA Septodont Biodentine; Calcium Silicate Cement Astringedent; FS NaOCl gel; Hypochlorite gel

Eligibility Criteria

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Inclusion Criteria

* Children aged between 4 and 7 years
* At least one primary molar indicated for pulpotomy
* No spontaneous pain or systemic infection
* Cooperative behavior according to the Frankl Behavior Rating Scale (scores 3 or 4)
* Signed informed consent from parents or legal guardians

Exclusion Criteria

* Medically compromised children or presence of systemic diseases (e.g., bleeding disorders, immunodeficiency)
* Uncooperative behavior (Frankl rating 1 or 2)
* Primary teeth with signs of pulpal necrosis, abscess, sinus tract, or non-restorable crown
* History of allergy to any materials used in the study
Minimum Eligible Age

4 Years

Maximum Eligible Age

7 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Inonu University

OTHER

Sponsor Role collaborator

Sacide Duman

OTHER

Sponsor Role lead

Responsible Party

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Sacide Duman

Assoc. Prof. Dr.

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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sacide duman, Assoc Prof

Role: PRINCIPAL_INVESTIGATOR

Inonu University, Faculty of Dentistry, Department of Pediatric Dentistry

Locations

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Inonu University, Faculty of Dentistry, Department of Pediatric Dentistry

Malatya, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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TSA-2021-2486.

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

2021/77-INUDF

Identifier Type: -

Identifier Source: org_study_id

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