Clinical Effectiveness of Episodic Use of Bioactive Silica Based Versus in Management of Dentin Hypersensitivity (A 6m Randomized Clinical Trial)
NCT ID: NCT07120139
Last Updated: 2025-08-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
50 participants
INTERVENTIONAL
2025-08-20
2026-02-28
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Group 1 Episodic use of Refix booster Bioactive Silica with calcium booster toothpaste
episodic use of the desensitizing toothpaste
subjects assigned to episodic treatment will use the assigned toothpaste with the same previous instructions for two 8-week treatment periods, followed by an 8-week phase in which they will use the conventional fluoride dentifrice (Signal Complete 8 Original, Unilever, Egypt), which has no documented desensitizing efficacy
Group 2: Episodic use of Regenerador Sentitive: Bioactive Silica Based toothpaste,
episodic use of the desensitizing toothpaste
subjects assigned to episodic treatment will use the assigned toothpaste with the same previous instructions for two 8-week treatment periods, followed by an 8-week phase in which they will use the conventional fluoride dentifrice (Signal Complete 8 Original, Unilever, Egypt), which has no documented desensitizing efficacy
Group 3: Episodic use of (Sensodyne Rapid action) Fluoride containing desensitizing Toothpaste,
episodic use of the desensitizing toothpaste
subjects assigned to episodic treatment will use the assigned toothpaste with the same previous instructions for two 8-week treatment periods, followed by an 8-week phase in which they will use the conventional fluoride dentifrice (Signal Complete 8 Original, Unilever, Egypt), which has no documented desensitizing efficacy
Group 4: Continuous use of (Sensodyne Rapid action) Fluoride containing desensitizing Toothpaste
continuous use of the conventional desensitizing toothpaste
The patients will be instructed to use 1 inch amount of the assigned desensitizing toothpaste and soft bristle toothbrushes with the same brushing technique they will be taught in the intervention visit for 2 minutes twice a day (morning and last thing at night ) without further rinsing, only spitting of the excess material every day along the whole study period for the continuous treatment group.
Interventions
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episodic use of the desensitizing toothpaste
subjects assigned to episodic treatment will use the assigned toothpaste with the same previous instructions for two 8-week treatment periods, followed by an 8-week phase in which they will use the conventional fluoride dentifrice (Signal Complete 8 Original, Unilever, Egypt), which has no documented desensitizing efficacy
continuous use of the conventional desensitizing toothpaste
The patients will be instructed to use 1 inch amount of the assigned desensitizing toothpaste and soft bristle toothbrushes with the same brushing technique they will be taught in the intervention visit for 2 minutes twice a day (morning and last thing at night ) without further rinsing, only spitting of the excess material every day along the whole study period for the continuous treatment group.
Eligibility Criteria
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Inclusion Criteria
• Teeth with DH related to Non- carious Cervical lesions (abrasion, abfracture, erosion).
• Teeth with gingival recession and exposed root dentin.
\-
Exclusion Criteria
Systematic disease and/ or physical disabilities that may affect participation. • Patients who did any periodontal surgeries within the previous 3 months.
• Patients with orthodontic appliances, or restorative work that might interfere with evaluation.
• Patient who frequently use analgesics or any drugs that could affect the pain level.
• Home or in-office bleaching and/ or in office fluoride application for 6 months before beginning of treatment.
• Pregnant females with frequent vomiting attacks.
• Smokers.
• Systemic conditions that cause or predispose patients to develop dentin hypersensitivity (for example, gastroesophageal reflux disease, GERD).
• Excessive dietary or environmental exposure to acids.
22 Years
45 Years
ALL
Yes
Sponsors
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Rawda Hesham Abd ElAziz
OTHER
Responsible Party
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Rawda Hesham Abd ElAziz
Associate Professor, Conservative dentistry department
Locations
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Cairo University
Cairo, , Egypt
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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CONS2R
Identifier Type: -
Identifier Source: org_study_id
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