Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
30 participants
OBSERVATIONAL
2023-10-15
2027-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Mild Alzheimer
Patients above 65 diagnosed with Alzheimer's Disease according to appropriate ICD-criterias.
7T MRI
Resting and activity-based MRI. Dring activity based MRI, the participant will complete tasks testing semantic memory.
EEG
Resting-state EEG
Blood samples
Blood samples taken for analysis of central blood biomarkers.
Stool samples
Stool samples collected to identify distinct gut-microbiota compositions between the groups.
Neuropsychologic test (MoCA)
Map cognition with clinically well-established neuropsychology test
Controls
Age- and gender-matched control group.
7T MRI
Resting and activity-based MRI. Dring activity based MRI, the participant will complete tasks testing semantic memory.
EEG
Resting-state EEG
Blood samples
Blood samples taken for analysis of central blood biomarkers.
Stool samples
Stool samples collected to identify distinct gut-microbiota compositions between the groups.
Neuropsychologic test (MoCA)
Map cognition with clinically well-established neuropsychology test
Interventions
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7T MRI
Resting and activity-based MRI. Dring activity based MRI, the participant will complete tasks testing semantic memory.
EEG
Resting-state EEG
Blood samples
Blood samples taken for analysis of central blood biomarkers.
Stool samples
Stool samples collected to identify distinct gut-microbiota compositions between the groups.
Neuropsychologic test (MoCA)
Map cognition with clinically well-established neuropsychology test
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* \>55years.
* Norwegian native speaker
* Lives at home and not in a health institution
Exclusion Criteria
* Presence of brain tumors.
* History of traumatic brain injury.
* History of cranial surgery.
* Contraindications to the selected imaging modalities (e.g., 7T MRI or EEG).
* Diagnosis of other neurodegenerative diseases such as Parkinson's disease or ALS.
7T MRI contraindications:
* Large tattoos close to the head region, permanent makeup or unremoveable piercings
* Certain models of pacemakers (if pacemaker implantet, MRI physicist at 7T-lab will be conferred)
* Implantet metal in body (clips, stents, prothesis, skrews, plates, teeth etc.)
55 Years
ALL
Yes
Sponsors
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Norwegian University of Science and Technology
OTHER
Responsible Party
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Principal Investigators
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Axel Sandvig Professor, MD PhD
Role: PRINCIPAL_INVESTIGATOR
Norwegian University of Science and Technology (NTNU)
Locations
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Norwegian University of Sciene and Technology / Norges teknisk-naturvitenskapelige universitet (NTNU)
Trondheim, Trønderlag, Norway
Countries
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Central Contacts
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Other Identifiers
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490656
Identifier Type: -
Identifier Source: org_study_id
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