Assessing Upper Extremity Function in Chronic Stroke Survivors Through Acute Intermittent Hypoxia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-08-01

Study Completion Date

2027-08-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Here we aim to observe effects of acute intermittent hypoxia in persons who have experienced a single stroke. We have previously shown this technique to be safe and effective at increasing strength in persons with disabilities, and here are aiming to determine the mechanism of how the breathing method modulates motor function.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

The Efficacy of Additional Motor Training Dosage During the Early Stages Post Stroke on the Upper Extremity Recovery

NCT07056049

Stroke Hemiplegia and Hemiparesis

RECRUITING NA

Effects of Inspiratory Muscle Training and Abdominal Drawing-In Maneuver on Balance, Gait and Pulmonary Function in Stroke Patients

NCT06838871

Subacute Stroke Balance Deficits

COMPLETED NA

Inpatient Stroke Recovery Using Sensors

NCT04219670

Stroke

RECRUITING

Robotic Enhanced Error Training of Upper Limb Function in Post-stroke Patients

NCT05174676

CVA (Cerebrovascular Accident) Paresis

UNKNOWN NA

Neuromodulation-Enhanced Use of RObotic BALANCE Training to Improve Balance Function in Individuals With Stroke

NCT07113041

Stroke Stroke (CVA) or Transient Ischemic Attack Stroke Ischemic +2 more

RECRUITING NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Here we aim to observe effects of acute intermittent hypoxia in persons who have experienced a single stroke. We have previously shown this technique to be safe and effective at increasing strength in persons with disabilities, and here are aiming to determine the mechanism of how the breathing method modulates motor function.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Stroke

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Hypoxia

Participants in this arm will receive approximately 15 bouts of acute intermittent hypoxia. This intervention involves breathing lowered levels of oxygen (similar to being on a tall mountain) for 60 seconds at a time, followed by 60 seconds of room air. Participants will be assessed following the intervention.

Group Type EXPERIMENTAL

Acute Intermittent Hypoxia (AIH)

Intervention Type OTHER

This intervention involves breathing lowered levels of oxygen (similar to those experienced on a tall mountain) for 60 seconds at a time. This is immediately followed by 60 seconds of breathing normal room air. These bouts are repeated approximately 15 times. For the intervention, the participant is fitted with a non-rebreathing mask which supplies the two different air levels

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Acute Intermittent Hypoxia (AIH)

This intervention involves breathing lowered levels of oxygen (similar to those experienced on a tall mountain) for 60 seconds at a time. This is immediately followed by 60 seconds of breathing normal room air. These bouts are repeated approximately 15 times. For the intervention, the participant is fitted with a non-rebreathing mask which supplies the two different air levels

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* A first time, unilateral, ischemic, hemispheric stroke, confirmed by MRI
* Chedoke stage of hand assessment \>= 3
* Ability to open and close affected hand
* Able to understand and communicate in english
* Able to independently consent
* over 6 months post stroke
* Must have a hemoglobin level above 10g/dl
* Must have ability to leave research visit with a compainon/group trasportation
* WOCBP must be comfortable confirming negative pregnancy prior to hypoxia
* Must not be involved in any other research intervention study testing upper extremities

Exclusion Criteria

* History of prior neurological disorders
* Brain stem or cerebellar stroke; mean Fazekas score rated on initial fluid-attenuated inversion recovery MRI greater than equal to 3
* Severe Aphasisa
* Pre-existing hypoxic pulmonary disease
* Includes positive Covid-pneumonia diagnosis within 1 year of screening visit
* Severe hypertension (\>160/100)
* Any ischemic cardiac disease

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No