Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
60 participants
OBSERVATIONAL
2024-04-04
2025-06-07
Brief Summary
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Detailed Description
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Hemorheology refers to the study of blood flow and its mechanical properties. In this study, key hemorheological parameters-including hematocrit (Hct), whole blood viscosity (WBV), plasma viscosity (PV), erythrocyte deformability (ED), and erythrocyte aggregation (EA)-will be assessed in AIS patients and healthy controls. A total of 30 AIS patients and 30 age- and sex-matched healthy participants will be enrolled.
Blood samples will be collected for rheological analysis, and measurements will be performed using a rotational cone-plate viscometer and a laser-optical erythrocyte analyzer under standardized shear conditions. Clinical and radiological data, such as Cobb angle, vertebral rotation, and sagittal alignment, will also be collected. Statistical comparisons between groups and correlation analyses will be conducted to evaluate the relationships between hemorheological variables and scoliosis severity or type.
This study will provide the first controlled assessment of hemorheological behavior in adolescents with idiopathic scoliosis. Results may offer novel insights into whether spinal deformity has systemic circulatory implications and may help identify early markers of microvascular dysfunction associated with AIS.
Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Patients
10-18 years old AIS patients
No interventions assigned to this group
Control Healthy Subjects
Sex and aged match healthy subjecyts
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Age between 10 and 18 years
Exclusion Criteria
* Presence of any diseases or conditions that may affect hemorheology, such as cardiovascular, respiratory, and hematologic diseases
* Obesity (Body mass index \[BMI\] \> 30)
* Being treated surgically for scoliosis
10 Years
18 Years
ALL
Yes
Sponsors
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Saglik Bilimleri Universitesi
OTHER
Fatih Sultan Mehmet Training and Research Hospital
OTHER
Responsible Party
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Aslinur Keles Ercisli, MD, PhD
Principal investigator
Principal Investigators
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Papatya Keles, professor
Role: STUDY_DIRECTOR
Saglik Bilimleri Universitesi
Locations
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University of Health Sciences
Istanbul, , Turkey (Türkiye)
Countries
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Related Links
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Lazari D, Freitas Leal JK, Brock R, Bosman G. The Relationship Between Aggregation and Deformability of Red Blood Cells in Health and Disease. Front Physiol 2020;11:288.
Ebenuwa I, Violet P-C, Tu H, Lee C, Munyan N, Wang Y, et al. Altered RBC deformability in diabetes: clinical characteristics and RBC pathophysiology. Cardiovasc Diabetol 2024;23:370.
Other Identifiers
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SBU-2025
Identifier Type: OTHER
Identifier Source: secondary_id
AHIAIS-2025
Identifier Type: -
Identifier Source: org_study_id
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