Assessment of Composite Inflammatory Ratios in Juvenile Idiopathic Arthritis and Their Association With Disease Activity

NCT ID: NCT07083466

Last Updated: 2025-07-24

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 90 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-07-15
• Study Completion Date: 2026-04-15

Brief Summary

Juvenile Idiopathic Arthritis (JIA) is a prevalent pediatric rheumatic disorder characterized by persistent inflammation of one or more joints in children and adolescents. This chronic condition is a major contributor to both short- and long-term morbidity and functional disability We aim in this study to investigate the role of CAR, PLR, NLR ,systemic inflammatory index (SII ) and NAR ( SII and NAR have never been evaluated before in JIA patients ) as potential markers of disease activity in patients with non-systemic JIA (nsJIA) .

Conditions

Juvenile Idiopathic Arthritis

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

case

cases under 16y established diagnosis juvenile idiopathic arthritis

complete blood count

Intervention Type: DIAGNOSTIC_TEST

blood test

serum albumin

Intervention Type: DIAGNOSTIC_TEST

blood test

control

below age 16 y not diagnosed with any autoimmune or systemic disease

complete blood count

Intervention Type: DIAGNOSTIC_TEST

blood test

serum albumin

Intervention Type: DIAGNOSTIC_TEST

blood test

Interventions

complete blood count

blood test

Intervention Type: DIAGNOSTIC_TEST

serum albumin

blood test

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

-

1. Patients who classified JIA according to International League of Associations for Rheumatology ILAR criteria on treatment with exclusion of systemic JIA.

2. Patients with disease duration more than 6 months. 3. Age below 16 years old. 4. Patient cooperative and can answer questions. 5. Patients who are able and willing to give written informed consent or their parents/guardians

Exclusion Criteria

• 1. Systemic JIA. 2. Patients with other autoimmune or autoinflammatory diseases, immunodeficiencies, hematologic conditions, malignances and infectious disease at enrollment time or in the previous 2 weeks.

Patients who are not able and willing to give written informed consent

• Maximum Eligible Age: 16 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Sohag University

OTHER

Sponsor Role: lead

Responsible Party

Hadeer Fadlalmawla Mohamed

resident at rheumatology and rehabilitation department at sohag university hospitals

Responsibility Role: PRINCIPAL_INVESTIGATOR

Central Contacts

Hadeer F Mohamed, resident

Role: CONTACT

hadeer.fadl@med.sohag.edu.eg

01030536331

osama S Daifallah, AssistantProf

Role: CONTACT

References

Huang JL. New advances in juvenile idiopathic arthritis. Chang Gung Med J. 2012 Jan-Feb;35(1):1-14. doi: 10.4103/2319-4170.106171.

Reference Type: BACKGROUND

PMID: 22483423 (View on PubMed)

Prakken B, Albani S, Martini A. Juvenile idiopathic arthritis. Lancet. 2011 Jun 18;377(9783):2138-49. doi: 10.1016/S0140-6736(11)60244-4.

Reference Type: BACKGROUND

PMID: 21684384 (View on PubMed)

Milovanovic M, Nilsson E, Jaremo P. Relationships between platelets and inflammatory markers in rheumatoid arthritis. Clin Chim Acta. 2004 May;343(1-2):237-40. doi: 10.1016/j.cccn.2003.12.030.

Reference Type: BACKGROUND

PMID: 15115702 (View on PubMed)

Erre GL, Paliogiannis P, Castagna F, Mangoni AA, Carru C, Passiu G, Zinellu A. Meta-analysis of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio in rheumatoid arthritis. Eur J Clin Invest. 2019 Jan;49(1):e13037. doi: 10.1111/eci.13037. Epub 2018 Nov 6.

Reference Type: BACKGROUND

PMID: 30316204 (View on PubMed)

Other Identifiers

Soh-Med-25-6-6MS

Identifier Type: -

Identifier Source: org_study_id