A Research Study to See How a Weekly Insulin, Insulin Icodec, Helps in Reducing the Blood Sugar Compared to Daily Insulin Glargine, Both in Combination With Insulin Aspart, in Adults With Type 1 Diabetes

NCT ID: NCT07076199

Last Updated: 2026-01-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE3

Total Enrollment

877 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-08-11

Study Completion Date

2026-12-28

Brief Summary

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This study compares insulin icodec, an insulin taken once a week to insulin glargine, an insulin taken once a day. The study medicine will be investigated in participants with type 1 diabetes. The study will look at how well insulin icodec taken weekly controls blood sugar compared to insulin glargine taken daily. The study will last for about 8.5 months.

Detailed Description

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Conditions

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Diabetes Mellitus, Type 1

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Insulin icodec + insulin aspart

Participants will receive subcutaneously once weekly insulin icodec in combination with 2-4 times daily insulin aspart .

Group Type EXPERIMENTAL

Insulin icodec

Intervention Type DRUG

Insulin icodec will be administered as subcutaneous injection

Insulin aspart

Intervention Type DRUG

Insulin aspart will be administered as a subcutaneous injection.

Insulin glargine+ insulin aspart

Participants will receive subcutaneously once daily insulin glargine in combination with 2-4 times daily insulin aspart.

Group Type ACTIVE_COMPARATOR

Insulin glargine

Intervention Type DRUG

Insulin glargine will be administered as subcutaneous injection.

Insulin aspart

Intervention Type DRUG

Insulin aspart will be administered as a subcutaneous injection.

Interventions

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Insulin icodec

Insulin icodec will be administered as subcutaneous injection

Intervention Type DRUG

Insulin glargine

Insulin glargine will be administered as subcutaneous injection.

Intervention Type DRUG

Insulin aspart

Insulin aspart will be administered as a subcutaneous injection.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Diagnosed with type 1 diabetes mellitus greater than or equal to (≥) 1 year before screening.
* Treated with multiple daily insulin injections (daily basal insulin analogue and bolus insulin analogue regimen) ≥ 6 months before screening.
* HbA1c from 7.0-10.0 percentage (%) (53.0-85.8 millimoles per mole (mmol/mol)), both inclusive, at screening confirmed by central laboratory analysis.
* Ability and willingness to adhere to the protocol including performance of self-measured plasma glucose (SMPG) profiles, based on the investigator's judgement.

Exclusion Criteria

* Known or suspected hypersensitivity to study intervention(s) or related products.
* Previous participation in this study. Participation is defined as signed informed consent.
* Female who is pregnant, breast-feeding or intends to become pregnant or is of childbearing potential and not using adequate contraceptive method.
* Exposure to an investigational medicinal product within 90 days or 5 half-lives of the investigational medicinal product (if known), whichever is longer, before screening.
* Any condition, except for conditions associated with type 1 diabetes mellitus, which in the investigator's opinion might jeopardise participant's safety or compliance with the protocol.
* Anticipated initiation or anticipated change in concomitant medications (for more than 15 consecutive days) known to affect weight or glucose metabolism (e.g., treatment with thyroid hormones, or systemic corticosteroids).
* Known hypoglycaemic unawareness as indicated by the Investigator according to Clarke's questionnaire question.
* Recurrent severe hypoglycaemic episodes within the last year as judged by the investigator.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Novo Nordisk A/S

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Transparency (dept. 2834)

Role: STUDY_DIRECTOR

Novo Nordisk A/S

Locations

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Cullman Clinical Trials

Cullman, Alabama, United States

Site Status RECRUITING

John Muir Health

Concord, California, United States

Site Status RECRUITING

Headlands Research California, LLC

Escondido, California, United States

Site Status RECRUITING

Clinical Res of Central Ca

Fresno, California, United States

Site Status RECRUITING

Providence Medical Foundation

Fullerton, California, United States

Site Status RECRUITING

Scripps Whittier Diabetes Inst

La Jolla, California, United States

Site Status RECRUITING

Loma Linda University Faculty Medical Clinics

Loma Linda, California, United States

Site Status RECRUITING

Loma Linda University Faculty Medical Clinics

Loma Linda, California, United States

Site Status NOT_YET_RECRUITING

Pacific Clinical Studies

Los Alamitos, California, United States

Site Status RECRUITING

Pasadena Clinical Trials

Pasadena, California, United States

Site Status RECRUITING

WestenU Health

Pomona, California, United States

Site Status COMPLETED

WestenU Health

Pomona, California, United States

Site Status WITHDRAWN

Alliance Clinical Network

San Diego, California, United States

Site Status RECRUITING

Mills Health Center

San Mateo, California, United States

Site Status RECRUITING

Center for Endocrine DM and Metabolic Disorders

Santa Clarita, California, United States

Site Status RECRUITING

University Clin Investigators

Tustin, California, United States

Site Status RECRUITING

Diablo Clinical Research, Inc.

Walnut Creek, California, United States

Site Status RECRUITING

Denver Endocrinology Diabetes and Thyroid Center

Englewood, Colorado, United States

Site Status NOT_YET_RECRUITING

Optumcare Clinical Trials,LLC-Golden

Golden, Colorado, United States

Site Status RECRUITING

Northeast Research Institute

Fleming Island, Florida, United States

Site Status RECRUITING

Suncoast Clinical Research, Inc.

New Port Richey, Florida, United States

Site Status RECRUITING

West Orange Endocrinology

Ocoee, Florida, United States

Site Status RECRUITING

Suncoast Clinical Research, Inc.

Palm Harbor, Florida, United States

Site Status RECRUITING

SRA Trials-Broward

Pembroke Pines, Florida, United States

Site Status RECRUITING

Hanson Clinical Research Center

Port Charlotte, Florida, United States

Site Status RECRUITING

Latin Clinical Trial Ctr

Tamarac, Florida, United States

Site Status RECRUITING

Bayside Clinical Research

Tampa, Florida, United States

Site Status RECRUITING

Metabolic Research Institute Inc

West Palm Beach, Florida, United States

Site Status RECRUITING

Atlanta Diabetes Associates

Atlanta, Georgia, United States

Site Status RECRUITING

Centricity Research Columbus

Columbus, Georgia, United States

Site Status RECRUITING

Physicians Research Assoc. LLC

Lawrenceville, Georgia, United States

Site Status RECRUITING

Endocrine Research Solutions, Inc

Roswell, Georgia, United States

Site Status RECRUITING

Rocky Mt Clin Res, LLC

Idaho Falls, Idaho, United States

Site Status RECRUITING

Northwestern University

Chicago, Illinois, United States

Site Status COMPLETED

University Of Chicago

Chicago, Illinois, United States

Site Status RECRUITING

Endeavor Health

Skokie, Illinois, United States

Site Status RECRUITING

Indiana Uni School of Med-Ped

Indianapolis, Indiana, United States

Site Status COMPLETED

Iowa Diabetes Research

Des Moines, Iowa, United States

Site Status RECRUITING

Cotton O’Neil Diabetes & Endocrinology

Topeka, Kansas, United States

Site Status RECRUITING

Robley Rex VA Medical Center

Louisville, Kentucky, United States

Site Status NOT_YET_RECRUITING

MedStar Health Research Institute

Hyattsville, Maryland, United States

Site Status RECRUITING

Brigham & Women's Hospital

Boston, Massachusetts, United States

Site Status RECRUITING

Profound Research LLC

Clarkston, Michigan, United States

Site Status RECRUITING

Elite Clinical Research Center

Flint, Michigan, United States

Site Status RECRUITING

International Diabetes Center

Minneapolis, Minnesota, United States

Site Status RECRUITING

Mayo Clinic

Rochester, Minnesota, United States

Site Status RECRUITING

Saint Louis University

St Louis, Missouri, United States

Site Status NOT_YET_RECRUITING

Washington University

St Louis, Missouri, United States

Site Status RECRUITING

Washington University

St Louis, Missouri, United States

Site Status NOT_YET_RECRUITING

University of Nebraska Medical Center

Omaha, Nebraska, United States

Site Status RECRUITING

QCR Network

Omaha, Nebraska, United States

Site Status RECRUITING

Palm Research Center Inc.

Las Vegas, Nevada, United States

Site Status RECRUITING

Albuquerque Clinical Trials Inc.

Albuquerque, New Mexico, United States

Site Status RECRUITING

AMC Community Endocrinology

Albany, New York, United States

Site Status RECRUITING

NYC Research, Inc.

New York, New York, United States

Site Status RECRUITING

NYU Langone Health

New York, New York, United States

Site Status RECRUITING

University at Buffalo

Williamsville, New York, United States

Site Status RECRUITING

Physicians East Endocrinology

Greenville, North Carolina, United States

Site Status RECRUITING

Lucas Research Inc.

Morehead City, North Carolina, United States

Site Status RECRUITING

Centricity Res New Bern

New Bern, North Carolina, United States

Site Status RECRUITING

Accellacare Wilmington

Wilmington, North Carolina, United States

Site Status RECRUITING

Diab & Endo Assoc of Stark Co

Canton, Ohio, United States

Site Status RECRUITING

Cleveland Clinic_Cleveland

Cleveland, Ohio, United States

Site Status NOT_YET_RECRUITING

The Ohio State University Medical Center

Columbus, Ohio, United States

Site Status RECRUITING

Alliance for Multispecialty Research

Norman, Oklahoma, United States

Site Status RECRUITING

Lynn Institute of Norman

Norman, Oklahoma, United States

Site Status RECRUITING

Lynn Institute - East OKC

Oklahoma City, Oklahoma, United States

Site Status RECRUITING

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, United States

Site Status RECRUITING

Prisma Health Endo Spc Thy Ctr

Greenville, South Carolina, United States

Site Status RECRUITING

Holston Medical Group_Bristol

Bristol, Tennessee, United States

Site Status RECRUITING

University Diabetes & Endocrine Consultants

Chattanooga, Tennessee, United States

Site Status RECRUITING

MidState Endocrine Associates

Nashville, Tennessee, United States

Site Status RECRUITING

Vanderbilt Medical Center_Nashville

Nashville, Tennessee, United States

Site Status NOT_YET_RECRUITING

Amarillo Medical Specialists

Amarillo, Texas, United States

Site Status RECRUITING

Texas Diab Endo ATX N Mopac EXPR

Austin, Texas, United States

Site Status RECRUITING

Texas Diabetes & Endocrinology

Austin, Texas, United States

Site Status RECRUITING

Alliance Clinical Network

Dallas, Texas, United States

Site Status RECRUITING

Thyroid Endocrinology & Diabetes PA

Dallas, Texas, United States

Site Status RECRUITING

Velocity Clinical Res-Dallas

Dallas, Texas, United States

Site Status RECRUITING

North Texas Endocrine Center

Dallas, Texas, United States

Site Status COMPLETED

Research Institute Of Dallas

Dallas, Texas, United States

Site Status RECRUITING

Precision Endo - Revival

Denton, Texas, United States

Site Status RECRUITING

Epic Medical Research

DeSoto, Texas, United States

Site Status RECRUITING

Frontier Medical Ctr

El Paso, Texas, United States

Site Status RECRUITING

N. Texas Diab & Endo - Prime

Flower Mound, Texas, United States

Site Status COMPLETED

N. Texas Diab & Endo - Prime

Flower Mound, Texas, United States

Site Status WITHDRAWN

Diabetes and Thyroid Center of Fort Worth

Fort Worth, Texas, United States

Site Status RECRUITING

Houston Endocrinology Center

Houston, Texas, United States

Site Status RECRUITING

The Endocrine Center

Houston, Texas, United States

Site Status RECRUITING

Amir Ali Hassan, MD, PA

Houston, Texas, United States

Site Status RECRUITING

RGV Endocrine Center

McAllen, Texas, United States

Site Status RECRUITING

Tekton Research

McKinney, Texas, United States

Site Status RECRUITING

Be Well Clinical Studies

Round Rock, Texas, United States

Site Status RECRUITING

Texas Diabetes & Endocrinology_Round Rock

Round Rock, Texas, United States

Site Status RECRUITING

Northeast Clinical Research of San Antonio

San Antonio, Texas, United States

Site Status RECRUITING

Valley Diab. & Endo Comp Ctr

Weslaco, Texas, United States

Site Status RECRUITING

Rio Clinical Trials

Ogden, Utah, United States

Site Status RECRUITING

UVM Endocrinology

South Burlington, Vermont, United States

Site Status COMPLETED

Rainier Clin Res Ctr Inc

Renton, Washington, United States

Site Status RECRUITING

Prevea Health

Green Bay, Wisconsin, United States

Site Status RECRUITING

Macquarie University

Macquarie Park, New South Wales, Australia

Site Status RECRUITING

Illawarra Diabetes Service Clinical Trials & Research Unit

Wollongong, New South Wales, Australia

Site Status RECRUITING

Townsville University Hospital

Townsville, Queensland, Australia

Site Status RECRUITING

Southern Adelaide Diabetes & Endocrine Services

Oaklands Park, South Australia, Australia

Site Status RECRUITING

St Vincent's Hospital - Melbourne

Fitzroy, Victoria, Australia

Site Status RECRUITING

Austin Health, Metabolic Disorders Centre

Heidelberg Heights, Victoria, Australia

Site Status RECRUITING

The Royal Melbourne Hospital

Parkville, Victoria, Australia

Site Status RECRUITING

Centricity Research Calgary Endocrinology

Calgary, Alberta, Canada

Site Status RECRUITING

University of Calgary

Calgary, Alberta, Canada

Site Status COMPLETED

Vancouver General Hospital_Vancouver_0

Vancouver, British Columbia, Canada

Site Status NOT_YET_RECRUITING

Winnipeg Clinic

Winnipeg, Manitoba, Canada

Site Status RECRUITING

Nova Scotia Health Authority

Halifax, Nova Scotia, Canada

Site Status RECRUITING

Centricity Research Brampton Endocrinology

Brampton, Ontario, Canada

Site Status RECRUITING

Centricity Research Etobicoke Endocrinology

Etobicoke, Ontario, Canada

Site Status RECRUITING

Premier Clinical Trial Research Network (PCTRN)

Hamilton, Ontario, Canada

Site Status RECRUITING

Western University Centre for Studies in Fam Med

London, Ontario, Canada

Site Status RECRUITING

Centricity Research Toronto LMC Multispec

Toronto, Ontario, Canada

Site Status RECRUITING

Centricity Research LMC

Toronto, Ontario, Canada

Site Status COMPLETED

Ctr de rech Clin de Laval

Laval, Quebec, Canada

Site Status WITHDRAWN

Ctr de recherche Clinique de Laval

Laval, Quebec, Canada

Site Status COMPLETED

Centricity Research Mirabel

Mirabel, Quebec, Canada

Site Status RECRUITING

McGill University Health Centre

Montreal, Quebec, Canada

Site Status NOT_YET_RECRUITING

Clinique Endocrinologie OASIS.

Montreal, Quebec, Canada

Site Status RECRUITING

Clin des Mal Lipid de Quebec

Québec, Quebec, Canada

Site Status RECRUITING

Centre de Médecine Métabolique de Lanaudière

Terrebonne, Quebec, Canada

Site Status RECRUITING

Centre de Médecine Métabolique de Lanaudière

Terrebonne, Quebec, Canada

Site Status NOT_YET_RECRUITING

Diabetespraxis Mergentheim

Bad Mergentheim, , Germany

Site Status RECRUITING

Herz- und Diabeteszentrum NRW - Bad Oeynhausen

Bad Oeynhausen, , Germany

Site Status RECRUITING

Medizinisches Versorgungszentrum Am Bahnhof Spandau GbR

Berlin, , Germany

Site Status RECRUITING

DSP Bochum, Diabetes- und Stoffwechselpraxis

Bochum, , Germany

Site Status RECRUITING

Uniklinik TU Dresden - Med. Klinik III

Dresden, , Germany

Site Status RECRUITING

Praxis für Diabetologie, Angiologie und Innere Medizin Eisenach

Eisenach, , Germany

Site Status NOT_YET_RECRUITING

InnoDiab Forschung GmbH

Essen, , Germany

Site Status RECRUITING

MVZ Diabeteszentrum Dr. Tews GmbH

Gelnhausen, , Germany

Site Status COMPLETED

Diabetes-Zentrum-Wilhelmsburg GbR

Hamburg, , Germany

Site Status RECRUITING

Diabetes Zentrum Wandsbek Berufsausuebungsgemeinschaft GbR

Hamburg, , Germany

Site Status RECRUITING

Wendisch/Dahl Hamburg (DZHW)

Hamburg, , Germany

Site Status RECRUITING

Die Praxis am Ludwigsplatz

Ludwigshafen, , Germany

Site Status RECRUITING

MedicalCenter am Clemenshospital - Schwerpunktpraxis für Diabetologie und Ernährungsmedizin

Münster, , Germany

Site Status RECRUITING

Institut für Diabetesforschung Osnabrück

Osnabrück, , Germany

Site Status RECRUITING

Zentrum für klinische Studien Alexander Segner

Saint Ingbert-Oberwürzbach, , Germany

Site Status RECRUITING

Zentrum für klinische Studien Allgäu Oberschwaben

Wangen, , Germany

Site Status COMPLETED

Med. Cent. Diabet. Endo. Metabol. DIAB-ENDO-MET

Krakow, Lesser Poland Voivodeship, Poland

Site Status RECRUITING

Formed 2 Sp. z o.o.

Oświęcim, Lesser Poland Voivodeship, Poland

Site Status RECRUITING

Metabolica Sp. z o.o.

Tarnów, Lesser Poland Voivodeship, Poland

Site Status RECRUITING

Beata Miklaszewicz & Dariusz Dabrowski "CARDIAMED" s.j.

Legnica, Lower Silesian Voivodeship, Poland

Site Status RECRUITING

Centrum Medyczne Intercor Sp. z o.o.

Bydgoszcz, , Poland

Site Status NOT_YET_RECRUITING

Uniwersyteckie Centrum Kliniczne (UCK)

Gdansk, , Poland

Site Status NOT_YET_RECRUITING

Gabinet Lekarski Malgorzata Saryusz-Wolska

Lodz, , Poland

Site Status RECRUITING

Gabinet Lekarski Malgorzata Saryusz-Wolska

Lodz, , Poland

Site Status NOT_YET_RECRUITING

Zanamed Medical Clinic Sp. z o.o.

Lublin, , Poland

Site Status RECRUITING

Zanamed Medical Clinic Sp. z o.o.

Lublin, , Poland

Site Status NOT_YET_RECRUITING

Reumed Sp. z o.o.

Lublin, , Poland

Site Status RECRUITING

ENDOPRACTICA W.Beker, D.Mielczarek, P.Mielczarek, J.Struzik spolka cywilna

Opole, , Poland

Site Status NOT_YET_RECRUITING

Formed 2 Sp. z o.o.

Oświęcim, , Poland

Site Status NOT_YET_RECRUITING

Irmed Klimkiewicz Rudziewicz-Kowalska sp. j.

Piotrkow Trybunalski, , Poland

Site Status RECRUITING

Uniwersyteckie Centrum Stomatologii i Medycyny Specjalistycznej Sp. z o.o.

Poznan, , Poland

Site Status RECRUITING

Gaja Poradnie Lekarskie

Poznan, , Poland

Site Status COMPLETED

PANSTWOWY INSTYTUT MEDYCZNY MSWiA

Warsaw, , Poland

Site Status RECRUITING

Zespol Wojewodzkich Przychodni Specjalistycznych W Katowicach SPZOZ

Zabrze, , Poland

Site Status RECRUITING

Zespol Wojewodzkich Przychodni Specjalistycznych W Katowicach SPZOZ

Zabrze, , Poland

Site Status NOT_YET_RECRUITING

Etg Zamosc Sp. z o.o.

Zamość, , Poland

Site Status RECRUITING

Centro de Endo Altagracia

Bayamón, , Puerto Rico

Site Status RECRUITING

Advanced Clinical Research LLC

Bayamón, , Puerto Rico

Site Status RECRUITING

S.C. Top Diabet Srl

Craiova, Dolj, Romania

Site Status RECRUITING

Diabmed Dr Popescu Alexandrina SRL

Ploieşti, Prahova, Romania

Site Status RECRUITING

CMI Dr. Pletea Noemi SRL

Bacau, , Romania

Site Status RECRUITING

Minimed S.R.L.

Bacau, , Romania

Site Status RECRUITING

Centrul Medical de Diagnostic si Tratament Ambulatoriu Neomed

Brasov, , Romania

Site Status RECRUITING

SC Nutrilife SRL

Bucharest, , Romania

Site Status RECRUITING

Diabs&Nutricare Srl

Bucharest, , Romania

Site Status NOT_YET_RECRUITING

Spitalul Clinic Judetean De Urgenta Sfantul Apostol Andrei Constanta

Constanța, , Romania

Site Status RECRUITING

SC Diamed Obesity SRL

Galati, , Romania

Site Status RECRUITING

S.C. Dianutrilife Medica S.R.L.

Ploieşti, , Romania

Site Status RECRUITING

Clinica Korall S.R.L. Satu Mare

Satu Mare, , Romania

Site Status RECRUITING

Spitalul Clinic Judetean de Urgenta Sibiu

Sibiu, , Romania

Site Status RECRUITING

Spitalul Judetean De Urgenta Sfantul Ioan Cel Nou Suceava

Suceava, , Romania

Site Status RECRUITING

Spitalul Clinic Judetean De Urgenta Pius Brinzeu Timisoara

Timișoara, , Romania

Site Status RECRUITING

DIABEDA s.r.o.

Bratislava, , Slovakia

Site Status RECRUITING

MEDISPEKTRUM s.r.o.

Bratislava, , Slovakia

Site Status RECRUITING

Diab - Int, s.r.o.

Bytča, , Slovakia

Site Status RECRUITING

DIOLI s.r.o.

Košice, , Slovakia

Site Status RECRUITING

HUMAN-CARE, s.r.o.

Košice, , Slovakia

Site Status RECRUITING

DIADAN, s.r.o. Kosice

Košice, , Slovakia

Site Status RECRUITING

Countries

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United States Australia Canada Germany Poland Puerto Rico Romania Slovakia

Central Contacts

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Novo Nordisk

Role: CONTACT

(+1) 866-867-7178

Other Identifiers

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U1111-1310-7017

Identifier Type: OTHER

Identifier Source: secondary_id

2024-519945-31

Identifier Type: OTHER

Identifier Source: secondary_id

NN1436-8182

Identifier Type: -

Identifier Source: org_study_id

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