A Research Study to Compare Two Types of Insulin, a New Insulin, Insulin Icodec and an Available Insulin, Insulin Glargine, in People With Type 2 Diabetes Who Have Not Used Insulin Before

NCT ID: NCT04460885

Last Updated: 2025-12-04

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

984 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-11-25

Study Completion Date

2022-12-01

Brief Summary

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This study compares insulin icodec (a new insulin taken once a week) to insulin glargine (an insulin taken once daily which is already available on the market) in people with type 2 diabetes.

The study will look at how well insulin icodec taken weekly controls blood sugar compared to insulin glargine taken daily. Participants will either get insulin icodec that participants will have to inject once a week on the same day of the week or insulin glargine that participants will have to inject once a day at the same time every day. Which treatment participants get is decided by chance.

The insulin is injected with a needle in a skin fold in the thigh, upper arm or stomach. The study will last for about 1 ½ years. Participants will have 37 clinic visits and 26 phone calls with the study doctor. At 11 clinic visits participant will have blood samples taken. At 8 clinic visits participants cannot eat or drink (except for water) for 8 hours before the visit.

Participants will be asked to wear a sensor that measures the blood sugar all the time in 5 periods of about one month during the study (about 5 months in total). Women cannot take part if pregnant, breast-feeding or plan to become pregnant during the study period.

Detailed Description

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Conditions

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Diabetes Mellitus, Type 2

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Insulin icodec

Insulin icodec + non-insulin anti-diabetic drugs. The pre-trial non-insulin anti-diabetic background medication should be maintained at the stable, pre-trial dose and at the same frequency during the entire treatment period

Group Type EXPERIMENTAL

Insulin icodec

Intervention Type DRUG

Participants will receive subcutaneous (s.c.) injections of insulin icodec once weekly for 78 weeks.

Insulin glargine

Insulin glargine + non-insulin anti-diabetic drugs. The pre-trial non-insulin anti-diabetic background medication should be maintained at the stable, pre-trial dose and at the same frequency during the entire treatment period

Group Type ACTIVE_COMPARATOR

Insulin glargine

Intervention Type DRUG

Participants will receive subcutaneous (s.c.) injections of insulin glargine once daily for 78 weeks

Interventions

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Insulin icodec

Participants will receive subcutaneous (s.c.) injections of insulin icodec once weekly for 78 weeks.

Intervention Type DRUG

Insulin glargine

Participants will receive subcutaneous (s.c.) injections of insulin glargine once daily for 78 weeks

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male or female aged above or equal to 18 years at the time of signing informed consent.
* Diagnosed with type 2 diabetes mellitus (T2D) 180 days or more prior to the day of screening.
* HbA1c from 7.0-11.0% (53.0-96.7 mmol/mol) both inclusive at screening confirmed by central laboratory analysis.
* Insulin naïve. However, short term insulin treatment for a maximum of 14 days prior to the day of screening is allowed, as is prior insulin treatment for gestational diabetes.
* Stable daily dose(s) 90 days or more prior to the day of screening of any of the following anti-diabetic drug(s) or combination regimen(s): a. Any metformin formulations at least or greater than 1500 mg or maximum tolerated or effective dose. b. Any metformin combination formulations equal to or above 1500 mg or maximum tolerated or effective dose. c. Any of the following oral anti-diabetic drug classes including combinations ((equal to or above half of the maximum approved dose according to local label or maximum tolerated or effective dose): Sulfonylureas, Meglitinides (glinides), dipeptidyl peptidase-4 (DPP-4) inhibitors, Sodium-glucose co-transporter-2 (SGLT2) inhibitors, Thiazolidinediones, Alpha-glucosidase inhibitors, Oral combination products (for the allowed individual oral anti-diabetic drugs), Oral or injectable glucagon-like peptide 1 (GLP-1) receptor agonists
* Body mass index (BMI) equal to or below 40.0 kg/m\^2.

Exclusion Criteria

* Any episodes (as declared by the subject or in the medical records) of diabetic ketoacidosis within 90 days prior to the day of screening.
* Myocardial infarction, stroke, hospitalisation for unstable angina pectoris or transient ischaemic attack within 180 days prior to the day of screening.
* Chronic heart failure classified as being in New York Heart Association Class IV at screening.
* Anticipated initiation or change in concomitant medications (for more than 14 consecutive days) known to affect weight or glucose metabolism (e.g. treatment with orlistat, thyroid hormones, or corticosteroids).
* Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Verified by a fundus examination performed within the past 90 days prior to screening or in the period between screening and randomisation. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Novo Nordisk A/S

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Transparency (1452)

Role: STUDY_DIRECTOR

Novo Nordisk A/S

Locations

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Kaplan MC - Metabolic Unit

Rehovot, , Israel

Site Status

Uni of Alabama at Birmingham

Birmingham, Alabama, United States

Site Status

Lakeview Clinical Research, LLC

Guntersville, Alabama, United States

Site Status

Lynn Institute of the Ozarks

Little Rock, Arkansas, United States

Site Status

Anaheim Clinical Trials

Anaheim, California, United States

Site Status

Advanced Clinical Research/Rancho Paseo Medical Group

Banning, California, United States

Site Status

American Clinical Trials

Buena Park, California, United States

Site Status

San Fernando Valley Hlth Inst, LLC

Canoga Park, California, United States

Site Status

Med Center Medical Clinic

Carmichael, California, United States

Site Status

Headlands Research California, LLC

Escondido, California, United States

Site Status

Valley Research

Fresno, California, United States

Site Status

Scripps Whittier Diabetes Inst

La Jolla, California, United States

Site Status

First Valley Medical Group

Lancaster, California, United States

Site Status

Clinical Trials Research_Sacramento

Lincoln, California, United States

Site Status

Torrance Clin Res Inst, Inc.

Lomita, California, United States

Site Status

Providence Clinical Research

North Hollywood, California, United States

Site Status

Valley Clinical Trials, Inc.

Northridge, California, United States

Site Status

Desert Oasis Hlthcr Med Group

Palm Springs, California, United States

Site Status

NorCal Endocrinology and Internal Medicine_Roseville

Roseville, California, United States

Site Status

Diabetes Research Center

Tustin, California, United States

Site Status

Coastal Metabolic Research Center

Ventura, California, United States

Site Status

Denver Endocrinology Diabetes and Thyroid Center

Englewood, Colorado, United States

Site Status

Chase Medical Research LLC

Waterbury, Connecticut, United States

Site Status

Revival Research

Doral, Florida, United States

Site Status

East Coast Institute for Research, LLC

Jacksonville, Florida, United States

Site Status

Jacksonville Ctr For Clin Res

Jacksonville, Florida, United States

Site Status

University Of Miami

Miami, Florida, United States

Site Status

Suncoast Clin Res Port Richey

New Port Richey, Florida, United States

Site Status

Florida Inst For Clin Res

Orlando, Florida, United States

Site Status

Palm Harbor Medical Associates

Palm Harbor, Florida, United States

Site Status

Suncoast Clinical Research, Inc.

Palm Harbor, Florida, United States

Site Status

Metabolic Research Institute Inc

West Palm Beach, Florida, United States

Site Status

Clinical Research of Cent FL

Winter Haven, Florida, United States

Site Status

Atlanta VA Medical Center

Decatur, Georgia, United States

Site Status

Physicians Research Assoc. LLC

Lawrenceville, Georgia, United States

Site Status

RNA America Health Sciences

Sugar Hill, Georgia, United States

Site Status

East West Medical Research Institute_Honolulu

Honolulu, Hawaii, United States

Site Status

Elite Clinical Trials

Blackfoot, Idaho, United States

Site Status

Cedar-Crosse Research Center

Chicago, Illinois, United States

Site Status

Clinical Invest Special_Gurnee

Gurnee, Illinois, United States

Site Status

Central Illinois Diabetes and Clinical Research

Springfield, Illinois, United States

Site Status

Iowa Diab & Endo Res Center

West Des Moines, Iowa, United States

Site Status

Cotton-O'Neil Diab & Endo Ctr

Topeka, Kansas, United States

Site Status

St Elizabeth Physicians Heart

Covington, Kentucky, United States

Site Status

Four Rivers Clinical Research Inc

Paducah, Kentucky, United States

Site Status

MedStar Hlth Res Institute

Hyattsville, Maryland, United States

Site Status

Endo And Metab Cons

Rockville, Maryland, United States

Site Status

Arcturus Healthcare, PLC.

Troy, Michigan, United States

Site Status

Diabetes & Endo Specialists Inc

Chesterfield, Missouri, United States

Site Status

Methodist Phys. Clinic

Omaha, Nebraska, United States

Site Status

Univ of Nebraska Medical CTR

Omaha, Nebraska, United States

Site Status

Palm Research Center Inc-Vegas

Las Vegas, Nevada, United States

Site Status

Southern NH Diabetes and Endo_Nashua

Nashua, New Hampshire, United States

Site Status

Albuquerque Clin Trials, Inc.

Albuquerque, New Mexico, United States

Site Status

N.Y. Total Medical Care PC

Brooklyn, New York, United States

Site Status

Northwell Health Div of Endo

Great Neck, New York, United States

Site Status

NYU Grossman School of Med

New York, New York, United States

Site Status

Endocrine Associates of Long Island, PC

Smithtown, New York, United States

Site Status

Southgate Medical Group, LLP

West Seneca, New York, United States

Site Status

University of North Carolina

Chapel Hill, North Carolina, United States

Site Status

Physicians East Endocrinology

Greenville, North Carolina, United States

Site Status

Medication Management, LLC

Raleigh, North Carolina, United States

Site Status

Accellacare

Wilmington, North Carolina, United States

Site Status

Ardmore Family Practice

Winston-Salem, North Carolina, United States

Site Status

Wake Forest School of Medicine

Winston-Salem, North Carolina, United States

Site Status

Plains Clinical Research Center, LLC

Fargo, North Dakota, United States

Site Status

Diab & Endo Assoc of Stark Co

Canton, Ohio, United States

Site Status

Providence Health Partners Ctr

Dayton, Ohio, United States

Site Status

Prestige Clinical Research

Franklin, Ohio, United States

Site Status

Your Diabetes Endocrine Nutrition Group, Inc.

Mentor, Ohio, United States

Site Status

Clinical Research Source Inc

Perrysburg, Ohio, United States

Site Status

Intend Research

Norman, Oklahoma, United States

Site Status

Oregon Health & Science University_Portland

Portland, Oregon, United States

Site Status

Heritage Valley Medical Group Inc

Beaver, Pennsylvania, United States

Site Status

Indiana-Armstrong Endocrinology Associates

Indiana, Pennsylvania, United States

Site Status

The Diabetes Center, LLC

Murrells Inlet, South Carolina, United States

Site Status

Hillcrest Clinical Research

Simpsonville, South Carolina, United States

Site Status

AM Diabetes And Endocrinology Center

Bartlett, Tennessee, United States

Site Status

WR-ClinSearch, LLC

Chattanooga, Tennessee, United States

Site Status

Holston Medical Group

Kingsport, Tennessee, United States

Site Status

Texas Diab & Endo, P.A.

Austin, Texas, United States

Site Status

Velocity Clinical Res-Dallas

Dallas, Texas, United States

Site Status

North Texas Endocrine Center

Dallas, Texas, United States

Site Status

UT Southwestern Med Cntr

Dallas, Texas, United States

Site Status

PrimeCare Medical Group

Houston, Texas, United States

Site Status

JCCT- Juno NW Houston

Houston, Texas, United States

Site Status

Fmc Science, Llc

Lampasas, Texas, United States

Site Status

Texas Diab & Endo, P.A.

Round Rock, Texas, United States

Site Status

Clinical Trials of Texas, LLC

San Antonio, Texas, United States

Site Status

NE Clin Res of San Antonio

San Antonio, Texas, United States

Site Status

Simcare Medical Research, LLC

Sugar Land, Texas, United States

Site Status

Elite Medical Care

Sugar Land, Texas, United States

Site Status

Wade Family Medicine

Bountiful, Utah, United States

Site Status

Advanced Research Institute

Ogden, Utah, United States

Site Status

Chrysalis Clinical Research

St. George, Utah, United States

Site Status

Danville Internal Medicine Inc

Danville, Virginia, United States

Site Status

TPMG Clinical Research

Newport News, Virginia, United States

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Rainier Clin Res Ctr Inc

Renton, Washington, United States

Site Status

Poliklinika SLAVONIJA OSIJEK

Osijek, County of Osijek-Baranja, Croatia

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Opca bolnica Karlovac

Karlovac, , Croatia

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KBC Rijeka, Endokrinologija

Rijeka, , Croatia

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Opca bolnica Varazdin_Endocrinology

Varaždin, , Croatia

Site Status

PGIMS Rohtak

Rohtak, Haryana, India

Site Status

TOTALL Diabetes Hormone Institute

Indore, Madhya Pradesh, India

Site Status

BYL Nair Hospital and T N Medical College Department of endo

Mumbai, Maharashtra, India

Site Status

Seth GS medical college and KEM Hospital

Mumbai, Maharashtra, India

Site Status

chelleram Diabetes Institute

Pune, Maharashtra, India

Site Status

All India Institute of Medical Sciences

New Dehli, New Delhi, India

Site Status

Madras Diabetes Research Foundation

Chennai, Tamil Nadu, India

Site Status

Christian Medical College Hospital, Vellore

Vellore, Tamil Nadu, India

Site Status

Gandhi Hospital & Medical college

Hyderabad, Telangana, India

Site Status

Osmania General Hospital

Hyderabad, Telangana, India

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Ramdev Rao Hospital

Hyderabad, Telangana, India

Site Status

SSKM

Kolkata, West Bengal, India

Site Status

Soroka MC - Outpatient Diabetes Clinic

Beersheba, , Israel

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Wolfson MC - Diabetes Clinic

Holon, , Israel

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Hadassah Ein Karam MC - Diabetes Unit

Jerusalem, , Israel

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Diabetes Clinic Meir MC

Kfar Saba, , Israel

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Rabin MC Beilinson - Department of Cardiothoracic Surgery

Petah Tikva, , Israel

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Policlinico Umberto I Seconda Clinica Medica

Roma, RM, Italy

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Azienda Ospedaliera Papa Giovanni XXIII

Bergamo, , Italy

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Policlinico Mater Domini Università di Catanzaro

Catanzaro, , Italy

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Ospedale Maggiore Policlinico UO Endocrinologia Diabetolgia

Milan, , Italy

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Policlinico Universitario Paolo Giaccone

Palermo, , Italy

Site Status

Hayashi Diabetes Clinic

Chigasaki-shi, Kanagawa, Kanagawa, Japan, Japan

Site Status

Hayashi Diabetes Clinic_Internal Medicine and Diabetes Medicine

Chigasaki-shi, Kanagawa, Japan, Japan

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Heiwadai Hospital_Internal Medicine

Miyazaki, Miyazaki, Japan

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The University of Tokyo Hospital, Diabetes and Metabolic

Bunkyo-ku, Tokyo, , Japan

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Tokuyama clinic_Diabetic internal medicine

Chiba, , Japan

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Futata Tetsuhiro Clinic Meinohama_Internal medicine

Fukuoka-shi, Fukuoka, , Japan

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Naka Kinen Clinic_Internal medicine

Ibaraki, , Japan

Site Status

Sugimoto Clinic,Internal Medicine

Kitakyusyu-shi, Fukuoka, , Japan

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Toranomon Hospital, Endocrinology and Metabolism

Minato-ku, Tokyo, , Japan

Site Status

Shinden Higashi Clinic_Miyagi

Miyagi, , Japan

Site Status

Takatsuki Red Cross Hospital_Diabetes and Endocrine Div.

Osaka, , Japan

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Shimizu Clinic Fusa

Saitama, , Japan

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Wakakusa Clinic

Shimotsuke-shi, Tochigi, , Japan

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Oyama East Clinic_Internal Medicine

Tochigi, , Japan

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Noritake Clinic

Ushiku-shi, Ibaraki, , Japan

Site Status

InstitutoJalisciense de Investigación en Diabetes y Obesidad

Guadalajara, Jalisco, Mexico

Site Status

Clínica Omega Diabetes, S.C.

Mexico City, México, D.F., Mexico

Site Status

Hospital Universitario Dr. José Eleuterio González_Monterrey

Monterrey, Nuevo León, Mexico

Site Status

Investigación Médica Sonora S.C.

Hermosillo, Sonora, Mexico

Site Status

NZOZ Przychodnia Specjalistyczna Medica

Lublin, Lubelski, Poland

Site Status

NZOZ "CenterMed Lublin" Sp. z o.o.

Lublin, Lublin Voivodeship, Poland

Site Status

Specjalistyczny Gabinet Diabetologiczny Radoslaw Rumianowski

Gorzów Wielkopolski, Lubusz Voivodeship, Poland

Site Status

NBR Polska Tomasz Klodawski

Warsaw, Masovian Voivodeship, Poland

Site Status

NZOZ Specjalistyczny Osrodek Internistyczno-Diabetologiczny Małgorzata Arciszewska

Bialystok, Podlaskie Voivodeship, Poland

Site Status

Centrum Medyczne "Diabetika"

Radom, , Poland

Site Status

Centrum Zdrowia Tuchow Sp z o.o.

Wierzchosławice, , Poland

Site Status

Prywatny Gabinet Janusz Gumprecht

Zabrze, , Poland

Site Status

Advanced Clinical Research LLC

Bayamón, , Puerto Rico

Site Status

Manati Ctr For Clin Research

Manatí, , Puerto Rico

Site Status

Consultorio Medico

San Juan, , Puerto Rico

Site Status

SAHI Kuzbass Hospital(former Regional clinical hospital)

Kemerovo, , Russia

Site Status

FSBI 'I.I. Dedov National Medical Research Center of Endocrinology' of the MH of Russia

Moscow, , Russia

Site Status

Setchenov First Moscow State Medical University

Moscow, , Russia

Site Status

Limited Law Company "Healthy Family" Medicine Center"

Novosibirsk, , Russia

Site Status

Scientifc Institute of Clinical and Experimental Lymphology

Novosibirsk, , Russia

Site Status

Penza Regional Clinical Hospital named after N.N. Burdenko

Penza, , Russia

Site Status

Limited Liability Company "Energiya Zdoroviya"

Saint Petersburg, , Russia

Site Status

Leningrad Regional Clinical Hospital

Saint Petersburg, , Russia

Site Status

Medinet LLC

Saint Petersburg, , Russia

Site Status

Consultative & Diagnostic Center with a Outpatient Hospital

Saint Petersburg, , Russia

Site Status

Regional clinical cardiology dispensary

Saratov, , Russia

Site Status

Siberian State Medical University

Tomsk, , Russia

Site Status

Voronezh Regional Clinical Consultive-diagnostic Centre

Voronezh, , Russia

Site Status

Polyclinic #2 in Yoshkar-Ola

Yoshkar-Ola, , Russia

Site Status

Peter Farkas MD, s.r.o.

Šahy, Slovak Republic, Slovakia

Site Status

Amb. diabetologie a poruch latkovej premeny a vyzivy

Bratislava, , Slovakia

Site Status

Diacrin s. r. o.

Bratislava, , Slovakia

Site Status

MEDISPEKTRUM s.r.o.

Bratislava, , Slovakia

Site Status

MediVet s.r.o.

Malacky, , Slovakia

Site Status

SIN AZUCAR s.r.o.

Malacky, , Slovakia

Site Status

Diabetologicka ambulancia SchronerMED, s.r.o.

Moldava nad Bodvou, , Slovakia

Site Status

ARETEUS s.r.o.

Trebišov, , Slovakia

Site Status

Complejo Hospitalario Universitario A Coruña

A Coruña, , Spain

Site Status

ABS La Roca del Vallés_Endocrinología

La Roca Del Vallés, , Spain

Site Status

Hospital Universitario de la Princesa

Madrid, , Spain

Site Status

Centro de Especialidades José Marva

Madrid, , Spain

Site Status

Hospital Quirón

Pozuelo de Alarcón, , Spain

Site Status

Hospital Universitario Quirónsalud Madrid

Pozuelo de Alarcón, , Spain

Site Status

Bollington Medical Centre

Bollington, Cheshire, United Kingdom

Site Status

Layton Medical Centre

Blackpool, , United Kingdom

Site Status

The Health Centre

Bradford-on-Avon, , United Kingdom

Site Status

Southmead Hospital

Bristol, , United Kingdom

Site Status

Addenbrooke's Hospital_Cambridge

Cambridge, , United Kingdom

Site Status

Countess of Chester Hospital

Chester, , United Kingdom

Site Status

The Adam Practice

Dorset, , United Kingdom

Site Status

Ninewells Hospital

Dundee, , United Kingdom

Site Status

Western General Hospital

Edinburgh, , United Kingdom

Site Status

Wycombe General Hospital

High Wycombe, , United Kingdom

Site Status

Burbage Surgery

Hinckley, , United Kingdom

Site Status

Queen Alexandra Hospital_Portsmouth

Portsmouth, , United Kingdom

Site Status

The Staploe Medical Centre

Soham, , United Kingdom

Site Status

Joint Clinical Research Facility - Swansea

Swansea, , United Kingdom

Site Status

Royal Cornwall Hospital (Treliske)

Truro, , United Kingdom

Site Status

Albany House Medical Centre

Wellingborough, , United Kingdom

Site Status

Countries

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United States Croatia India Israel Italy Japan Mexico Poland Puerto Rico Russia Slovakia Spain United Kingdom

References

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Philis-Tsimikas A, Bajaj HS, Begtrup K, Cailleteau R, Gowda A, Lingvay I, Mathieu C, Russell-Jones D, Rosenstock J. Rationale and design of the phase 3a development programme (ONWARDS 1-6 trials) investigating once-weekly insulin icodec in diabetes. Diabetes Obes Metab. 2023 Feb;25(2):331-341. doi: 10.1111/dom.14871. Epub 2022 Oct 14.

Reference Type RESULT
PMID: 36106652 (View on PubMed)

Mohan V, Kesavadev J, Murthy LS, Anil G, Chandrappa M, Kar S, Mishra S. Efficacy and Safety of Once-Weekly Insulin Icodec in Indian Participants with Diabetes: Results from ONWARDS 1, 4, and 6 Studies. Diabetes Ther. 2025 Nov;16(11):2193-2212. doi: 10.1007/s13300-025-01799-4. Epub 2025 Oct 6.

Reference Type DERIVED
PMID: 41051694 (View on PubMed)

Philis-Tsimikas A, Krogsdahl Bache J, Fu A, Kellerer M, Salvesen-Sykes K, Bain SC. Insights on Hospitalisations from the Phase 3a ONWARDS 1-6 Trials of Once-Weekly Insulin Icodec. Diabetes Ther. 2025 Aug;16(8):1615-1631. doi: 10.1007/s13300-025-01745-4. Epub 2025 Jun 4.

Reference Type DERIVED
PMID: 40465144 (View on PubMed)

Riddell MC, Heller S, Carstensen L, Rocha TMP, Kehlet Watt S, Woo VC. The effect of once-weekly insulin icodec vs once-daily basal insulin on physical activity-attributed hypoglycaemia in type 2 diabetes: a post hoc analysis of ONWARDS 1-5. Diabetologia. 2025 Jul;68(7):1416-1422. doi: 10.1007/s00125-025-06414-6. Epub 2025 Apr 5.

Reference Type DERIVED
PMID: 40186685 (View on PubMed)

Bergenstal RM, Asbjornsdottir B, Watt SK, Lingvay I, Mader JK, Nishida T, Rosenstock J. Continuous glucose monitoring-based metrics and the duration of hypoglycaemia events with once-weekly insulin icodec versus once-daily insulin glargine U100 in insulin-naive type 2 diabetes: an exploratory analysis of ONWARDS 1. Lancet Diabetes Endocrinol. 2024 Nov;12(11):799-810. doi: 10.1016/S2213-8587(24)00220-1. Epub 2024 Oct 4.

Reference Type DERIVED
PMID: 39374601 (View on PubMed)

Polonsky W, Benamar M, Carstensen L, Davies M, Meller Donatsky A, Franek E, Kellerer M, Philis-Tsimikas A, Goldenberg R. Improved treatment satisfaction with once-weekly insulin icodec compared with once-daily basal insulin in individuals with type 2 diabetes: An analysis of patient-reported outcomes and participant interviews from ONWARDS 2 and 5 and a physician survey from ONWARDS 1. Diabetes Res Clin Pract. 2024 Nov;217:111885. doi: 10.1016/j.diabres.2024.111885. Epub 2024 Oct 4.

Reference Type DERIVED
PMID: 39368488 (View on PubMed)

Watada H, Asbjornsdottir B, Nishida T, Nishimura R, Yamamoto Y, Yamauchi T, Kadowaki T. Efficacy and safety of once-weekly insulin icodec versus once-daily basal insulin in Japanese individuals with type 2 diabetes: A subgroup analysis of the ONWARDS 1, 2 and 4 trials. Diabetes Obes Metab. 2024 Dec;26(12):5882-5895. doi: 10.1111/dom.15960. Epub 2024 Sep 30.

Reference Type DERIVED
PMID: 39344833 (View on PubMed)

Rosenstock J, Bain SC, Gowda A, Jodar E, Liang B, Lingvay I, Nishida T, Trevisan R, Mosenzon O; ONWARDS 1 Trial Investigators. Weekly Icodec versus Daily Glargine U100 in Type 2 Diabetes without Previous Insulin. N Engl J Med. 2023 Jul 27;389(4):297-308. doi: 10.1056/NEJMoa2303208. Epub 2023 Jun 24.

Reference Type DERIVED
PMID: 37356066 (View on PubMed)

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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U1111-1247-3878

Identifier Type: OTHER

Identifier Source: secondary_id

2020-000442-34

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

NN1436-4477

Identifier Type: -

Identifier Source: org_study_id

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