Evaluation of Left Ventricular Function to Predict Weaning Success in the Intensive Care Unit
NCT ID: NCT07075926
Last Updated: 2025-09-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
50 participants
OBSERVATIONAL
2025-07-31
2026-07-16
Brief Summary
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Can the Left Ventricular Outflow Tract Velocity Time Integral (LVOT VTI) predict successful extubation?
What is the prognostic value of other echocardiographic measures such as Mitral Annular Plane Systolic Excursion (MAPSE), E/e' ratio, E/A ratio, Mitral Deceleration Time (MDT), and Myocardial Performance Index (Tei index) in forecasting weaning outcomes?
Participants will:
Be adults receiving mechanical ventilation and scheduled for weaning
Undergo transthoracic echocardiography (TTE) within 2 hours after meeting weaning criteria
Have the following parameters measured: LVOT VTI, MAPSE, E/e', E/A, MDT, and Tei index
Be monitored for 24 hours post-extubation to determine if they remain off ventilatory support, including reintubation, non-invasive ventilation, or high-flow oxygen therapy
This study aims to provide a comprehensive understanding of how systolic, diastolic, and global cardiac functions influence extubation success, potentially improving ICU decision-making and reducing complications, length of stay, and healthcare costs.
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Detailed Description
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Following fulfillment of weaning criteria, patients will undergo TTE evaluation within 2 hours. The echocardiographic assessment will include the measurement of:
Left Ventricular Outflow Tract Velocity Time Integral (LVOT VTI)
Mitral Annular Plane Systolic Excursion (MAPSE)
E/e' ratio
E/A ratio
Mitral Deceleration Time (MDT)
Myocardial Performance Index (Tei index)
These measurements aim to reflect systolic, diastolic, and global left ventricular functions. After the echocardiographic assessment, patients will be followed for 24 hours to determine weaning success, defined as the ability to maintain spontaneous breathing without reintubation, non-invasive ventilation, or high-flow oxygen support.
By integrating non-invasive, bedside cardiac function assessments into the extubation decision-making process, the study seeks to contribute to more physiologically guided weaning strategies. The results may help reduce weaning-related complications and optimize resource use in critical care settings
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Weaning Candidates
This group includes adult ICU patients who are receiving mechanical ventilation and have met standardized weaning criteria. All patients in this cohort will undergo transthoracic echocardiographic (TTE) assessment before extubation, without any experimental intervention applied.
Echocardiographic Assessment
All participants will receive a standardized transthoracic echocardiographic (TTE) examination within 2 hours after meeting weaning criteria. The following cardiac function parameters will be recorded:
LVOT Velocity Time Integral (VTI)
Mitral Annular Plane Systolic Excursion (MAPSE)
E/e' ratio
E/A ratio
Mitral Deceleration Time (MDT)
Myocardial Performance Index (Tei index)
The echocardiographic data will be used to investigate the association between left ventricular function and weaning success.
Interventions
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Echocardiographic Assessment
All participants will receive a standardized transthoracic echocardiographic (TTE) examination within 2 hours after meeting weaning criteria. The following cardiac function parameters will be recorded:
LVOT Velocity Time Integral (VTI)
Mitral Annular Plane Systolic Excursion (MAPSE)
E/e' ratio
E/A ratio
Mitral Deceleration Time (MDT)
Myocardial Performance Index (Tei index)
The echocardiographic data will be used to investigate the association between left ventricular function and weaning success.
Eligibility Criteria
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Inclusion Criteria
* Planned extubation after meeting standard weaning criteria
* Hemodynamically stable at the time of echocardiographic evaluation
* Written informed consent obtained from the patient or legally authorized representative
Exclusion Criteria
* Presence of significant valvular heart disease or known cardiomyopathy
* Inadequate acoustic window for transthoracic echocardiography
* Ongoing use of extracorporeal support (e.g., ECMO)
* Patients with Do-Not-Resuscitate (DNR) orders or expected to die within 24 hours
* Re-intubation planned prophylactically regardless of clinical status
* Pregnant patients
18 Years
ALL
No
Sponsors
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Kanuni Sultan Suleyman Training and Research Hospital
OTHER
Responsible Party
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Engin Ihsan Turan
principal investigator
Locations
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Health Science University İstanbul Kanuni Sultan Süleyman Education and Training Hospital
Istanbul, Istanbul, Turkey (Türkiye)
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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Weaning-Left Heart
Identifier Type: -
Identifier Source: org_study_id
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