Clinical Study Evaluating the Efficacy and Safety of Colchicine in Adult Patients With Sepsis

NCT ID: NCT07074990

Last Updated: 2025-07-23

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 46 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-11-01
• Study Completion Date: 2024-08-30

Brief Summary

Inflammatory markers are found to be an important contributor in sepsis. We evaluate the effect of colchicine on inflammatory processes and its possible protective effect against oxidative stress and organ dysfunction in adult patients suffering from sepsis.

Detailed Description

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis and septic shock are major healthcare problems, impacting millions of people around the world each year and killing between one in three and one in six of those it affects. Early identification and appropriate management in the initial hours after the development of sepsis improve outcomes .

Large quantities of proinflammatory cytokines released in patients with sepsis may spill into the bloodstream, contributing to the progression of a local infection to sepsis. These include tumor necrosis factor alpha (TNF-α), interleukin-1 (IL-1) and, interleukin-6 (IL-6), all of them can cause fever, hypotension, leukocytosis, induction of other proinflammatory cytokines, and the simultaneous activation of coagulation and fibrinolysis.

Taken together of all the aspects of the pathogenesis of sepsis, treatment modalities with anti-inflammatory effects could be considered for the successful treatment of sepsis. The available treatment strategies for management of sepsis include the use of fluid resuscitation and Empiric antibiotic therapy .

However, the limited success of antimicrobial in reducing the high mortality associated with sepsis and septic shock, increasing antibiotic resistance and medicine-resistant hemodynamic changes and our improved understandings of the pathogenesis of sepsis have resulted in further research on new treatment modalities in addition to classical treatments .

In particular, the identification of endotoxin-induced TNF-α and IL-1 production during sepsis as a major mediator of host damage, which culminates in potentially irreversible multi-organ dysfunction and shock, has led to the experimental use of a variety of interventions .

In this condition, novel agents must be developed or old drugs could be re-purposed to provide greater therapeutic outcome with fewer side effects at a minimum cost. Considering these facts, compounds from natural products may be considered as a promising and fruitful strategy for the treatment of sepsis.

Colchicine is a tricyclic, lipid-soluble alkaloid extracted from the plant of the Lily family Colchicum autumnale. The therapeutic use of colchicine has been well documented in gout and familial Mediterranean fever. it has also been used in other diseases including Behcet's disease, pericarditis, coronary artery disease and other inflammatory and fibrotic conditions .

Hypothesis: In this context, the outcomes of the previous animal studies and pilot study can provide a proof of concept for the implication of colchicine in clinical settings in order to improve the outcome in patients with sepsis and its efficacy in management of sepsis may depend on its anti-inflammatory and antioxidant effects.

Conditions

Sepsis at Intensive Care Unit

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

Group 1 (Control group)

Group Type: PLACEBO_COMPARATOR

conventional sepsis therapy alone

Intervention Type: DRUG

fluid resuscitation a minimum of 30 mL/kg of intravenous (IV) crystalloid fluid administered during the initial 3 hours of resuscitation, along with empiric antibiotic therapy aimed at the suspected pathogens and infection sites, ideally starting within the first hour.

Group 2 (Colchicine group)

Group Type: ACTIVE_COMPARATOR

colchicine 500 mcg oral twice daily plus conventional sepsis therapy.

Intervention Type: DRUG

colchicine 500 mcg oral twice daily plus conventional sepsis therapy for 5 days.

Interventions

conventional sepsis therapy alone

fluid resuscitation a minimum of 30 mL/kg of intravenous (IV) crystalloid fluid administered during the initial 3 hours of resuscitation, along with empiric antibiotic therapy aimed at the suspected pathogens and infection sites, ideally starting within the first hour.

Intervention Type: DRUG

colchicine 500 mcg oral twice daily plus conventional sepsis therapy.

colchicine 500 mcg oral twice daily plus conventional sepsis therapy for 5 days.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Adult age ≥18 years old.
• Both male and female sex.
• Patients diagnosed with sepsis regardless its etiology according to the definitions of SSC .

Exclusion Criteria

• Late septic shock at presentation with multiple organ failure.
• Serious gastrointestinal disease.
• Preexisting end stage liver disease.
• Preexisting end stage renal disease
• Pregnancy and breast-feeding women.
• History of allergy or intolerance to Colchicine.
• Patient with malignancies.
• Uncontrolled hemorrhage.
• Burn.
• Patients on immunosuppressant or biological therapies.
• Concomitant use of P-glycoprotein (P-gp) inhibitor such as: Verapamil, and Amiodarone or strong CYP3A4 inhibitor such as: Clarithromycin, Ritonavir and Ketoconazole.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Tanta University

OTHER

Sponsor Role: lead

Responsible Party

Randa Hamza Ismail Elmohr

Dr

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Faculty of Pharmacy - Tanta University

Tanta, Tanta, Egypt

Countries

Egypt

Other Identifiers

colchicine in sepsis

Identifier Type: -

Identifier Source: org_study_id