An International Study on Pediatric Patients With Rare Tumors.

NCT ID: NCT07072143

Last Updated: 2025-07-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

6250 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-01-25

Study Completion Date

2049-06-06

Brief Summary

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The PARTNER study is an international, prospective, observational study of paediatric patients with very rare tumours.

Detailed Description

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There are some very rare tumors (with an annual incidence of less than two per million children) that can affect children and adolescents. These neoplasms include a wide variety of cancers; some are rare at any age, while others are typical of adults but very rare in children. Due to their rarity, studies have so far been scarce, often lacking univocal diagnostic criteria, and more information is needed to improve treatment outcomes.

The aim of this study is to collect epidemiological, clinical, biological, radiological and treatment data on children and adolescents with rare cancers in order to improve our understanding of these tumors and how their clinical and biological characteristics affect treatment outcomes.

Due to the rarity of these malignancies, international collaboration is necessary to collect sufficient data on each tumour type.

While the investigators are not proposing specific treatments, the data collected will inform recommendations for the diagnosis and treatment of patients.

The PARTNER Study is an observational, prospective study. It is sponsored by Padua University Hospital AOUP (Italy), and all European centres collaborating with the EXPeRT group have been invited to participate. It is a non-profit study, meaning it has no commercial purpose, only the aim of improving knowledge and treatment for children with rare cancers. PARTNER activities are supported in different countries by national funds, as well as by the European Commission through the European Reference Network for Paediatric Oncology (ERN PaedCan). Please visit https://paedcan.ern-net.eu/ for more information.

Conditions

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Paraganglioma/ Phaeochromocytoma Melanoma and Other Malignant Neoplasms of Skin Gastrointestinal Stromal Tumor (GIST) Adrenocortical Tumor Pancreatic Tumors Esthesioneuroblastoma, Olfactory Mesothelioma Nasopharyngeal Carcinoma (NPC) NUT Carcinoma Pleuropulmonary Blastoma Salivary Gland Tumors Thymic Tumors Thyroid Carcinoma Appendiceal Cancers

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Children and adolescents (age 0-18 years) with a primary or relapsed Very Rare Tumor diagnosed and/or treated in a participating country/center.
* Written informed consent from the patient and/or the parent/legal guardian

Exclusion Criteria

* Absence of Written informed consent from the patient and/or the parent/legal guardian
Minimum Eligible Age

0 Years

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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St. Anna Children's Hospital, Vienna

UNKNOWN

Sponsor Role collaborator

Children's Hospital Zagreb

OTHER

Sponsor Role collaborator

Centre Hospitalier Universitaire de La Réunion, FRANCE

UNKNOWN

Sponsor Role collaborator

Klinikum Dortmund

UNKNOWN

Sponsor Role collaborator

University Children's Hospital Tuebingen

OTHER

Sponsor Role collaborator

Hellenic Oncology Research Group

OTHER

Sponsor Role collaborator

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

OTHER

Sponsor Role collaborator

Kaplan Medical Center, Rehovot, Israel

UNKNOWN

Sponsor Role collaborator

Vilnius University hospital Santaros klinikos, Vilnius, Lithuania

UNKNOWN

Sponsor Role collaborator

University of Skopje

OTHER

Sponsor Role collaborator

Gdansk Medical University (Poland)

UNKNOWN

Sponsor Role collaborator

Centro Hospitalar do Porto

OTHER

Sponsor Role collaborator

Bucharest Emergency Hospital

OTHER

Sponsor Role collaborator

Institute for Oncology and Radiology Serbia, Belgrade

UNKNOWN

Sponsor Role collaborator

University Hospital Bratislava

OTHER

Sponsor Role collaborator

University Medical Centre Ljubljana

OTHER

Sponsor Role collaborator

University of Bilbao

UNKNOWN

Sponsor Role collaborator

Göteborg University

OTHER

Sponsor Role collaborator

University Hospital, Paris

OTHER

Sponsor Role collaborator

Azienda Ospedaliera di Padova

OTHER

Sponsor Role lead

Responsible Party

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Gianni Bisogno

Professor of Paediatrics

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Gianni Bisogno, MD

Role: PRINCIPAL_INVESTIGATOR

Azienda Ospedale Università Padova - Italy

Locations

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Pediatric Oncology Unit, University Hospital Padova [AOUP Azienda Ospedale Università Padova]

Padua, Italy, Italy

Site Status RECRUITING

Countries

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Italy

Central Contacts

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Gianni Bisogno, MD

Role: CONTACT

0039 0498211481

Martina Bonel, CRC

Role: CONTACT

0039 04908211481

Facility Contacts

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Gianni Bisogno, Medical Doctor

Role: primary

0039 0498211481

Martina Bonel, Study Coordinator

Role: backup

0039 049 8214413

References

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Orbach D, Ferrari A, Schneider DT, Reguerre Y, Godzinski J, Bien E, Stachowicz-Stencel T, Surun A, Almaraz RL, Dragomir M, Jani D, Ami TB, Roganovic J, Brecht IB, Ladenstein R, Bisogno G. The European Paediatric Rare Tumours Network - European Registry (PARTNER) project for very rare tumors in children. Pediatr Blood Cancer. 2021 Jun;68 Suppl 4:e29072. doi: 10.1002/pbc.29072. Epub 2021 Apr 29.

Reference Type BACKGROUND
PMID: 33913610 (View on PubMed)

Related Links

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https://www.raretumors-children.eu/partner-project/

The page describes the PARTNER project inside the website of SIOP Europe (the European Society for Paediatric Oncology)

Other Identifiers

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The PARTNER study (AOP3417)

Identifier Type: -

Identifier Source: org_study_id

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