Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
100 participants
OBSERVATIONAL
2024-09-01
2027-10-31
Brief Summary
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1. Direct Bruch's Membrane Alterations: Longitudinal analysis of BrM reflectivity using high-resolution OCT to assess correlations with disease progression
2. Choriocapillaris Flow Deficits: Evaluation of choriocapillaris (CC) perfusion in relation to BrM calcification, aiming to clarify whether CC deficits precede or result from BrM changes
3. Retinal Atrophy Progression: Monitoring the development and expansion of retinal atrophic areas over two years, including correlations with specific features like reticular pseudodrusen and hyperreflective spots
4. Genotype-Phenotype Correlation: Analysis of different ABCC6 gene mutations to identify correlations with imaging features and disease severity, potentially guiding future personalized therapeutic strategies
The study will recruit 100 PXE patients and 100 controls, with data collection over 10 years. It involves non-invasive imaging and blood sampling. No direct benefit is expected for participants, but the findings may inform future clinical trials and improve patient counseling.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Pseudoxanthoma elasticum (PXE)
Genetically confirmed PXE patients
No interventions assigned to this group
Controls
Healthy eyes of control participants
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Clear ocular media
* Ability to perform the tasks of the study protocol (i.e., holding the head still for image aquisition)
Exclusion Criteria
* Systemic diseases hindering the study examinations
ALL
Yes
Sponsors
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University Hospital, Bonn
OTHER
Responsible Party
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Kristina Pfau
Principal Investigator
Locations
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Department of Ophthalmology, University Hospital Bonn, Germany
Bonn, North Rhine-Westphalia, Germany
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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UBonn
Identifier Type: -
Identifier Source: org_study_id
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