The Predictive Value of Doppler Based Renal Ultrasound and Urinary Oxygen Tension for Prediction of Acute Kidney Injury After Open Heart Surgery
NCT ID: NCT07037485
Last Updated: 2025-06-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
50 participants
OBSERVATIONAL
2024-10-01
2026-09-01
Brief Summary
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Detailed Description
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The renal artery pulsatility index (RAPI), which is determined using Doppler measurements, has been reported to detect patients with a high risk of AKI. Additionally, the renal resistance index (RRI), measured by Doppler ultrasound, can accurately predict the occurrence of AKI.
Urinary oxygen partial pressure in the bladder has been shown to decrease in the setting of sepsis, reduced renal blood flow, and decreased cardiac output.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Study group
Patients undergoing elective on-pump cardiac surgery
Renal resistive index
It will be measured with ultrasound-Doppler using an abdominal curvilinear probe ultrasonography by two independent, trained sonographers (who will not be involved in patient care). After visualizing the kidney in ultrasound mode and checking for renal abnormalities, an arcuate or inter-lobar artery will be localized, and three successive Doppler measurements at different positions in the kidney (high, middle, and low) will be performed. The average value for each kidney will be taken.
The renal resistive index will be calculated as follows:
(systolic peak flow velocity - diastolic minimum flow velocity)/systolic peak flow velocity
Renal Artery Pulsatility Index
It will be measured using an abdominal curvilinear probe ultrasonography by two independent, trained sonographers (who will not be involved in patient care). After visualizing the kidney, the interlobular artery will be located using color Doppler mode, and the velocity of the interlobular arteries will be assessed in one or two kidneys.
The Renal Artery Pulsatility Index (RAPI) will be calculated as follows:
RAPI = \[(peak systolic velocity) - (end diastolic velocity)\] /average velocity
Urinary oxygen tension (PUO2)
Urinary oxygen tension (PUO2) will be measured preoperatively (baseline), postoperatively just after intensive care unit admission, 12 hours after surgery, and then once daily for 7 days.
Interventions
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Renal resistive index
It will be measured with ultrasound-Doppler using an abdominal curvilinear probe ultrasonography by two independent, trained sonographers (who will not be involved in patient care). After visualizing the kidney in ultrasound mode and checking for renal abnormalities, an arcuate or inter-lobar artery will be localized, and three successive Doppler measurements at different positions in the kidney (high, middle, and low) will be performed. The average value for each kidney will be taken.
The renal resistive index will be calculated as follows:
(systolic peak flow velocity - diastolic minimum flow velocity)/systolic peak flow velocity
Renal Artery Pulsatility Index
It will be measured using an abdominal curvilinear probe ultrasonography by two independent, trained sonographers (who will not be involved in patient care). After visualizing the kidney, the interlobular artery will be located using color Doppler mode, and the velocity of the interlobular arteries will be assessed in one or two kidneys.
The Renal Artery Pulsatility Index (RAPI) will be calculated as follows:
RAPI = \[(peak systolic velocity) - (end diastolic velocity)\] /average velocity
Urinary oxygen tension (PUO2)
Urinary oxygen tension (PUO2) will be measured preoperatively (baseline), postoperatively just after intensive care unit admission, 12 hours after surgery, and then once daily for 7 days.
Eligibility Criteria
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Inclusion Criteria
* Both sexes.
* Undergoing elective on-pump cardiac surgery.
Exclusion Criteria
* Patients with any renal pathology or anatomic kidney abnormalities.
* Patients on renal replacement therapy.
21 Years
ALL
No
Sponsors
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Tanta University
OTHER
Responsible Party
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Amany Mohamed Badr Ali Badr
Assistant Lecturer of Anesthesiology, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt
Locations
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Tanta University
Tanta, El-Gharbia, Egypt
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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36265MD279/9/24
Identifier Type: -
Identifier Source: org_study_id
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