Autoimmune Protocol Diet Intervention on Proteinuria in IgA Nephropathy Patients

NCT ID: NCT07022574

Last Updated: 2025-06-15

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 30 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2026-02-01
• Study Completion Date: 2027-12-01

Brief Summary

This study at UCLA Center for Health Sciences is testing whether the Autoimmune Protocol (AIP) diet can lower protein levels in the urine of people with IgA Nephropathy (IgAN), a common kidney disease that can lead to kidney failure. The AIP diet avoids foods that may cause inflammation (like dairy, grains, and sugar) for 8 weeks, then gradually reintroduces them over 4 months. We're enrolling 30 adults aged 18-65 with IgAN and protein in their urine to try this diet for 6 months. Participants will track their urine protein daily at home, keep a food log, and have monthly lab checkups, with support from a diet expert. The main goal is to see if the diet reduces urine protein by 20% or more, which could slow disease progression and reduce the need for treatments like dialysis. This exploratory study aims to find out if diet changes can help manage IgAN.

Detailed Description

This study, conducted at UCLA Center for Health Sciences, explores the potential of the Autoimmune Protocol (AIP) diet as a novel intervention for IgA Nephropathy (IgAN), a chronic kidney condition driven by immune system dysfunction. IgAN involves the deposition of galactose-deficient IgA1 (Gd-IgA1) in the glomeruli, triggering inflammation and progressive renal damage. Emerging evidence points to the gut, particularly the gastric-associated lymphoid tissue (GALT), as a key site where aberrant immune responses initiate this process. The AIP diet, a structured elimination and reintroduction plan, has shown promise in reducing inflammation in other autoimmune conditions like inflammatory bowel disease and rheumatoid arthritis. This study builds on a clinical observation of proteinuria reduction in an IgAN patient post-renal transplant following AIP diet adoption, aiming to test its broader applicability.

The intervention spans 6 months and is divided into two phases. The initial 8-week elimination phase removes foods known to provoke inflammation-such as dairy, grains, legumes, nightshades, and refined sugars-which may influence GALT activity and Gd-IgA1 production. This is followed by a 4-month reintroduction phase, where foods are systematically re-added to assess individual tolerances and their impact on renal markers. Unlike pharmacological approaches targeting downstream effects (e.g., ACE inhibitors) or upstream Gd-IgA1 production (e.g., Budesonide), the AIP diet offers a non-invasive strategy to modulate mucosal immunity. The study hypothesizes that reducing dietary inflammatory triggers could decrease immune complex formation, thereby lowering proteinuria and potentially altering disease trajectory.

Participants will receive extensive support, including initial training from a certified AIP nutritionist, two AIP cookbooks, and ongoing guidance via email or phone consultations. Daily home monitoring involves urine dipsticks to measure protein levels, complemented by weekly food journaling to track adherence and identify correlations with urinary changes. Monthly in-person visits will collect blood and urine samples for laboratory analysis, including Chem7, to assess renal function and metabolic health. This single-center, open-label design prioritizes feasibility and real-world applicability, with no placebo group, as the focus is on detecting a signal of efficacy in a small cohort.

The study's scientific foundation rests on the multi-hit pathogenesis model of IgAN, where mucosal immune dysregulation in the gut precedes renal injury. By targeting GALT, which constitutes a significant portion of the body's immune interface, the AIP diet may reduce the production of pathogenic IgA1. Previous dietary studies in IgAN, such as gluten-free interventions, have hinted at gut-renal connections, but none have tested a comprehensive low-inflammation approach like AIP. Technical considerations include the use of the urinary protein-to-creatinine ratio as a reliable, non-invasive marker of proteinuria, validated in nephrology research for its sensitivity to treatment effects.

Safety is a priority, with risks limited to mild discomfort from blood draws (e.g., bruising), dietary adjustment challenges, and minimal inconvenience from daily urine testing. Adverse events will be logged and reported per IRB standards, with monthly lab monitoring ensuring early detection of any renal or metabolic concerns. The study's exploratory nature and small sample size (n=30) aim to generate preliminary data, with statistical power calculated to detect a 20% proteinuria reduction.

Funded by individual donations, this research is independent of commercial interests, covering costs for lab tests, dietary education, and participant support materials. Findings will contribute to the growing understanding of diet's role in kidney disease management, with results shared through peer-reviewed journals and scientific conferences. This study represents a first step toward integrating dietary strategies into IgAN care, offering a low-risk, patient-centered complement to existing therapies.

Conditions

IgA Nephropathy (IgAN)

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

AIP Intervention arm

Autoimmune Protocol Diet intervention

Group Type: EXPERIMENTAL

Low inflammation diet intervention

Intervention Type: BEHAVIORAL

Autoimmune Protocol Diet intervention

Interventions

Low inflammation diet intervention

Autoimmune Protocol Diet intervention

Intervention Type: BEHAVIORAL

Other Intervention Names

Autoimmune Protocol Diet

Eligibility Criteria

Inclusion Criteria

• Age 18-65
• Diagnosed with IgA Nephropathy (IgAN)
• Active disease with urine protein/creatinine ratio ≥ 1
• Stable ARB or ACE inhibitor for at least 1 month prior
• GFR > 30
• Not on Budesonide 1 month prior or during study

Exclusion Criteria

• Inability to comply with dietary or follow-up requirements
• Participation in other interventional studies
• Significant comorbidities interfering with study participation -

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of California, Los Angeles

OTHER

Sponsor Role: lead

Responsible Party

Thuy T. Tran, MD

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

UCLA

Manhattan Beach, California, United States

Countries

United States

Central Contacts

Thuy T Tran, MD

Role: CONTACT

tttran@mednet.ucla.edu

213-474-6452

Facility Contacts

Thuy T Tran, MD

Role: primary

tttran@mednet.ucla.edu

213-474-6452

References

Konijeti GG, Kim N, Lewis JD, Groven S, Chandrasekaran A, Grandhe S, Diamant C, Singh E, Oliveira G, Wang X, Molparia B, Torkamani A. Efficacy of the Autoimmune Protocol Diet for Inflammatory Bowel Disease. Inflamm Bowel Dis. 2017 Nov;23(11):2054-2060. doi: 10.1097/MIB.0000000000001221.

Reference Type: BACKGROUND

PMID: 28858071 (View on PubMed)

Other Identifiers

IRB# 25-0145

Identifier Type: -

Identifier Source: org_study_id