Efficacy of Leuconostoc Mesenteroides

NCT ID: NCT07017088

Last Updated: 2025-06-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-08-13

Study Completion Date

2025-02-28

Brief Summary

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Excessive alcohol intake can cause dehydration, digestive issues, oxidative stress, and hangover symptoms like headache and fatigue. Toxic metabolites like acetaldehyde and ROS contribute to liver damage. Chronic drinking activates harmful pathways like MEOS and increases inflammation. Gut-liver axis disruption also worsens hangovers. Probiotics, such as Leuconostoc mesenteroides, may help restore gut health and reduce toxicity, but more clinical research is needed.

Detailed Description

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Conditions

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Alcohol Drinking Alcohol Drinking Related Problems

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Single arm

Single group

Treatment

Group Type EXPERIMENTAL

Leuconostoc mesenteroides

Intervention Type DIETARY_SUPPLEMENT

Control vs Experiment

Interventions

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Leuconostoc mesenteroides

Control vs Experiment

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Healthy adults aged between 30 and 60 years
* Body Mass Index (BMI) between 18.5 and 30 kg/m²
* Individuals with a history of hangover experience
* Adults with normal results in blood tests and vital signs
* No organic gastrointestinal disease found in endoscopy within the past 3 months
* Able to consume one bottle of soju within 30 minutes
* Individuals who have personally signed the informed consent form

Exclusion

* Individuals who have consumed excessive alcohol within the past week
* Individuals who participated in a human clinical trial within the past month
* Individuals taking supplements or medications that may affect alcohol metabolism
* Individuals with alcohol metabolism disorders, diabetes, hypertension, gallstones, pancreatitis, gout, active tuberculosis, gastrointestinal bleeding or surgery, or those with kidney, liver (e.g., hepatitis B/C carriers, alcoholic liver disease), heart, lung, gastrointestinal, or neurological diseases
* Pregnant women or those planning to become pregnant
* Individuals who have taken liver function supplements or similar medications/health products within one month before the study
* Individuals who consumed excessive alcohol within one week prior to study participation
* Any other individuals deemed unsuitable for the study by the principal investigator
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Wonju Severance Christian Hospital

OTHER

Sponsor Role lead

Responsible Party

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Kyu Jae Lee

Prof.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Prof. Kyu-Jae Lee

Wŏnju, Gangwon-do, South Korea

Site Status

Countries

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South Korea

Other Identifiers

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EMB-2024-04

Identifier Type: -

Identifier Source: org_study_id

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