Pathogenic Mechanisms Involved in the Initiation and Progression of Systemic Sclerosis
NCT ID: NCT07015060
Last Updated: 2025-06-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
15 participants
INTERVENTIONAL
2025-06-30
2031-03-31
Brief Summary
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Perform (spatial) transcriptomic and proteomic analyses of affected skin from patients with and without cutaneous fibrosis, for the patterns and levels of expression/activation of candidate genes and pathways.
Test for dysregulation of expression/activation of candidate genes and pathways in live cells isolated from the blood and skin biopsy of patients, and for the impact of these dysregulations on cell appearance, behavior and function.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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PathSSc
cutaneous biospy
cutaneous biospy
Interventions
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cutaneous biospy
cutaneous biospy
Eligibility Criteria
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Inclusion Criteria
* Limited SSc
* Limited cutaneous SSc
* Diffuse cutaneous SSc
* Patients followed regularly in consultations at CUSL.
* Patients between ages 18-80.
Exclusion Criteria
* Pregnancy
* Participants with temporary or definitive disabilities to give consent
* Participants unable to sign or read the inform consent form
18 Years
80 Years
ALL
Yes
Sponsors
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Université Catholique de Louvain
OTHER
Responsible Party
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Principal Investigators
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Nisha Limaye, PhD
Role: STUDY_DIRECTOR
Université Catholique de Louvain
Central Contacts
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Other Identifiers
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PathSSC
Identifier Type: -
Identifier Source: org_study_id
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