Validation of a Questionnaire to Identify Signs and Symptoms of Nephrogenic Systemic Fibrosis

NCT ID: NCT00869479

Last Updated: 2010-12-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-03-31

Study Completion Date

2010-09-30

Brief Summary

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The Primary Aim of this study is to validate a questionnaire as a screening tool to identify subjects with symptoms suggestive of nephrogenic systemic fibrosis (NSF). The investigators believe that there will be difference between subjects with NSF and other skin conditions and normal skin.

Detailed Description

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Conditions

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Nephrogenic Systemic Fibrosis

Keywords

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Nephrogenic Systemic Fibrosis Screening

Study Design

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Study Time Perspective

CROSS_SECTIONAL

Study Groups

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1

subjects with a histologically-proven diagnosis of NSF

No interventions assigned to this group

2

subjects with other fibrosing skin diseases

No interventions assigned to this group

3

subjects with non-fibrosing skin diseases

No interventions assigned to this group

4

subjects without skin diseases

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

1. Male or female subjects 18 years of age or older.
2. Willing and able to understand and provide oral informed consent.
3. Able to complete study and comply with study procedures.

Exclusion Criteria

1. Subject is unable to provide oral consent.
2. Psychiatric or other conditions which might, in the opinion of the Principal Investigator, interfere with study evaluations or pose a risk to subject safety during the study.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Massachusetts General Hospital

OTHER

Sponsor Role lead

Responsible Party

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Massachusetts General Hospital

Principal Investigators

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Jonathan Kay, MD

Role: PRINCIPAL_INVESTIGATOR

Massachusetts General Hospital

Locations

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Massachusetts General Hospital

Boston, Massachusetts, United States

Site Status

Countries

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United States

References

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Todd DJ, Kay J. Nephrogenic systemic fibrosis: an epidemic of gadolinium toxicity. Curr Rheumatol Rep. 2008 Jul;10(3):195-204. doi: 10.1007/s11926-008-0033-6.

Reference Type BACKGROUND
PMID: 18638427 (View on PubMed)

Todd DJ, Kagan A, Chibnik LB, Kay J. Cutaneous changes of nephrogenic systemic fibrosis: predictor of early mortality and association with gadolinium exposure. Arthritis Rheum. 2007 Oct;56(10):3433-41. doi: 10.1002/art.22925.

Reference Type BACKGROUND
PMID: 17907148 (View on PubMed)

Lima XT, Alora-Palli MB, Kimball AB, Kay J. Validation of a screening instrument for nephrogenic systemic fibrosis. Arthritis Care Res (Hoboken). 2013 Apr;65(4):637-42. doi: 10.1002/acr.21877.

Reference Type DERIVED
PMID: 23097320 (View on PubMed)

Other Identifiers

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2008P002371

Identifier Type: -

Identifier Source: org_study_id