Bevacizumab Versus Triamcinolone Acetonide for the Treatment of Keloids.

NCT ID: NCT07014280

Last Updated: 2025-06-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE4

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-09-01

Study Completion Date

2025-07-01

Brief Summary

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The study compares the efficacy and safety of intralesional bevacizumab versus corticosteroids for the treatment of keloids. Assessment will be done clinically by the use of Modified Vancouver Scar Scale. Erythema index will be measured by spectrophotometry. The levels of Vascular Endothelial Growth Factor, collagen type 1 and collagen type 3 in the lesions before and after each treatment modality.

Detailed Description

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Conditions

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Keloids

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Intralesional bevacizumab injection

Intralesional bevacizumab injection for the treatment of keloid

Group Type ACTIVE_COMPARATOR

Bevacizumab

Intervention Type DRUG

anti-VEGF

Intralesional corticosteroid injection

Intralesional triamcinolone acetonide injection for the treatment of keloids

Group Type ACTIVE_COMPARATOR

Triamcinolone Acetonide

Intervention Type DRUG

corticosteroid

Interventions

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Bevacizumab

anti-VEGF

Intervention Type DRUG

Triamcinolone Acetonide

corticosteroid

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients with keloids (post-traumatic, any site, any duration)
* Age \>18 years
* Patients who didn't receive any treatment for the lesions in the past 6 weeks

Exclusion Criteria

* Patients who are pregnant, willing to get pregnant or lactating
* History of any liver or renal disease
* History of any cardiovascular disease
* History of hypertension
* History of thrombo-embolic events
* Known cases of bleeding disorders
* History of peptic ulcer
* Patients who underwent any surgeries in the last month
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Kasr El Aini Hospital

OTHER

Sponsor Role lead

Responsible Party

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Rana F Hilal, MD

Assistant professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Kasr El Ainy University Hospital, faculty of medicine, Cairo university

Cairo, El Manial, Egypt

Site Status

Countries

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Egypt

Other Identifiers

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BevaVSsteroid:keloids

Identifier Type: -

Identifier Source: org_study_id

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