Partial Sleep Restriction in Chronic Low Back Pain: A Feasibility Study

NCT ID: NCT07008924

Last Updated: 2025-06-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-07-14

Study Completion Date

2025-12-31

Brief Summary

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Our goal is to observational study is to determine feasibility of partial sleep restriction in individuals with CLBP+I and correlation findings with features of central sensitization.

* Identify feasibility of sleep restriction protocol
* Identify correlation between less sleep and central sensitization Sleep will be monitored for 2 weeks (baseline sleep monitoring period). Then participants will be asked to restrict their sleep to 80% of their normal sleep duration for 5 nights (sleep restriction period). Then sleep will be monitored again for 2 weeks (sleep recovery period).

Detailed Description

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Actigraph and sleep diaries will be used to record sleep time and quality of sleep for 2 weeks baseline period. During this period several measures for pain, sleep, fatigue, cognition, and psychological status will be completed. Quantitative sensory testing will be used to establish pain threshold. Then, the participants will partial sleep restriction (20% sleep reduction/night for 5 nights). Following the completion of restricted sleep period, all outcome measures related to pain, sleep, fatigue, cognition, and psychological status will be assessed (post-sleep restriction assessment). Then participants' sleep will be monitored for 2-weeks (sleep recovery period). During the 5-night of sleep restriction, participants will be asked to complete electronic daily diary related to sleep, pain, fatigue, psychological distress and physical activity. Potential risk related to less sleep will be clearly explained to all potential individuals interested in participating.

Conditions

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Chronic Low-back Pain Insomnia Sleep

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Healthy Control

Healthy control group will consist of those without any pain and sleep issues.

No intervention is provided. We monitor natural recovery to full sleep.

Intervention Type OTHER

Return to normal sleep observation.

Chronic Low Back Pain (CLBP)

CLBP group will consist of those with LBP. Individuals with CLBP who also experience minor sleep issues are also eligible.

No intervention is provided. We monitor natural recovery to full sleep.

Intervention Type OTHER

Return to normal sleep observation.

Interventions

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No intervention is provided. We monitor natural recovery to full sleep.

Return to normal sleep observation.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

• 25-65 years old individuals


* With or without insomnia
* CLBP (LBP for at least 3 months with or without referred or radiating leg pain; pain intensity 1 or greater on 0 - 10 VAS scale
* likely to participate in all scheduled evaluations and study procedures by self-report
* agrees to abide by safely protocol e.g. not to drive or operate heavy machinery and perform heavy labor work, during the sleep-restriction period

Exclusion Criteria

* spine compression, tumor, infection, history of spine surgery
* neurological conditions such as stroke, Parkinson's disease, Alzheimer's disease or other cognitive impairments.
* pregnancy
* known untreated sleep disorder (such as current sleep apnea or current restless leg syndrome) screened by the following scales to ensure insomnia symptoms are due to insomnia and not another common sleep disorders:
* Those with increased risk of sleep apnea
* Increased risk of restless leg syndrome on RLS-Diagnosis Index
* Increased risk of circadian rhythm sleep-wake disorder
* Increased risk of parasomnia
* Moderate level of depression identified by Patient Health Questionnaire (PHQ-9)
* Moderate level of anxiety identify by Generalized Anxiety Disorder (GAD-7)
* history of drug or alcohol abuse as defined by DSM-IV criteria within the last 2 years
* severe mental illness such as schizophrenia or bipolar disorder
* developmental history of learning disability or attention-deficit/hyperactivity disorder
* is currently receiving CBT-I, physical therapy or chiropractic treatment
* history of spinal surgery
* current use of blood thinning medications
* resting blood pressure greater than 160/90 mmHg40,49,50
* performs overnight shift work


• pain rating 0 out of 0 - 10 Numeric Rating Pain Scale in any parts of the body
Minimum Eligible Age

25 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Kansas Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Neena Sharma, PT, PhD, CMPT

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Neena Sharma

Role: PRINCIPAL_INVESTIGATOR

university

Locations

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University of Kansas Medical Center

Kansas City, Kansas, United States

Site Status

Countries

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United States

Other Identifiers

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STUDY00148602

Identifier Type: -

Identifier Source: org_study_id

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