Testicular Sperm Retrieval Rate After Varicocele Ligation in Men With Non Obstructive Azoospermia
NCT ID: NCT07008495
Last Updated: 2025-06-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
50 participants
INTERVENTIONAL
2024-09-01
2025-08-31
Brief Summary
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Male factor infertility affects up to half of all couples struggling to conceive, and 10-20% of men evaluated for infertility are found to be azoospermic.
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Detailed Description
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Non-obstructive azoospermia (NOA) is most often a result of primary testicular dysfunction, Varicoceles are found in 20% of the general male population, in up to 40% of men with infertility, and specifically 4.3-13.3% of men with NOA.
The role of varicoceles in NOA has not been fully elucidated. The current best practice statement on the evaluation of azoospermic males from the AUA acknowledges that impaired spermatogenesis associated with varicoceles may be reversible but does not give a clear recommendation for management.
The primary advantage of varicocelectomy in cases of NOA is the possibility of getting motile sperms in the ejaculate. Other benefit of varicocele repairs in azoospermic men is that there are increased success rates of assisted reproductive techniques (ART) such as intracytoplasmic sperm injection (ICSI) or testicular sperm extraction (TESE).
Conditions
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Study Design
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RANDOMIZED
PARALLEL
DIAGNOSTIC
NONE
Study Groups
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Group of varicocele ligation
About 25 male patients will undergo varicocele ligation then microTESE.
varicocelectomy
to detect testicular sperm retrieval rate after varicocelectomy in men with non obstructive azoospermia.
Group of TESE
About 25 male patients will undergo microTESE without varicocele ligation.
varicocelectomy
to detect testicular sperm retrieval rate after varicocelectomy in men with non obstructive azoospermia.
Interventions
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varicocelectomy
to detect testicular sperm retrieval rate after varicocelectomy in men with non obstructive azoospermia.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Clinically palpable varicocele ( unilateral or bilateral ).
Exclusion Criteria
* Non palpable varicocele.
* Uncorrectable female causes of infertility.
* genetic abnormalities like klinefelter syndrome.
20 Years
60 Years
MALE
No
Sponsors
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South Valley University
OTHER
Responsible Party
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Yacoub Nagah Abdelwahab
Resident at Urology Department, Faculty of Medicine
Principal Investigators
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Gamal A. Alsagheer, Professor
Role: STUDY_CHAIR
Urology Department, Faculty of Medicine, South Valley University, Qena, Egypt
Locations
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South Valley University Hospital
Qina, South Valley, Egypt
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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Non-Obstructive Azoospermia
Identifier Type: -
Identifier Source: org_study_id
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