Laparoscopic Sleeve Gastrectomy-Induced Decline in Plasma Asprosin and Its Association With Metabolic Recovery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

85 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-01-01

Study Completion Date

2025-01-31

Brief Summary

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the present study aimed to systematically assess the changes in plasma asprosin levels at 3, 6, and 12 months after LSG, to explore the relationships between asprosin dynamics and key metabolic parameters, including body mass index (BMI), fasting glucose, insulin resistance assessed by the homeostasis model (HOMA-IR), and lipid profiles, and to compare asprosin concentrations between bariatric patients and healthy normal-weight controls.

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Detailed Description

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Conditions

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Obesity, Morbid

Study Design

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Observational Model Type

CASE_CROSSOVER

Study Time Perspective

RETROSPECTIVE

Study Groups

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surgery

Intervention Type PROCEDURE

laparoscopic sleeve gastrectomy

Interventions

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surgery

laparoscopic sleeve gastrectomy

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

1. age between 18 and 65 years;
2. body mass index (BMI) ≥37.5 kg/m², or BMI ≥32.5 kg/m² with at least one obesity-related comorbidity;
3. availability of complete clinical data and stored plasma samples at preoperative baseline and at 3, 6, and 12 months postoperatively.

Exclusion Criteria

1. history of prior bariatric or gastrointestinal surgery;
2. active malignancy, chronic inflammatory or infectious disease, or severe hepatic or renal dysfunction;
3. pregnancy during the study period;
4. incomplete clinical or biochemical data.

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes