The Role of Bariatric Surgeries in Management of Nonalcoholic Fatty Liver Disease
NCT ID: NCT04127370
Last Updated: 2019-10-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
95 participants
INTERVENTIONAL
2019-11-01
2020-11-01
Brief Summary
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Detailed Description
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Unlike NAFLD, Nonalcoholic steatohepatitis is more aggressive and is associated with a risk of approximately 10 to 29% of progression to cirrhosis within10 years. Therefore, early-stage NASH represents a group of patients that is most likely to benefit from treatments in order to prevent progression to cirrhosis and its complications. Obesity is the most common and well documented risk factor for NAFLD, the majority (\>95%) of patients with severe obesity undergoing bariatric surgery will have NAFLD. To date, weight loss achieved via lifestyle intervention remains the mainstay of treatment of NASH.
Bariatric surgery contributes to weight loss in two main ways: restrictive procedures and malabsorptive procedures.
In 2018, the AASLD board stated that it is premature to consider foregut bariatric surgery as an established option to specifically treat NASH. Accordingly, the effects of bariatric surgery on hepatic fibrosis are still unclear. In Egypt there is lack in such type of study thus this research will conducted to evaluate the prevalence of NAFLD and NASH in obese patients undergoing bariatric surgery and to assess the role of bariatric surgery in management of NAFLD related hepatic morbidity in our locality.
Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Obese Patients With NAFALD Undergoing Bariatric Surgeries
Bariatric Surgery
The Role of Bariatric Surgeries in Management of Nonalcoholic Fatty Liver Disease
Interventions
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Bariatric Surgery
The Role of Bariatric Surgeries in Management of Nonalcoholic Fatty Liver Disease
Eligibility Criteria
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Inclusion Criteria
2. morbid obesity
3. severe obesity with as arterial hypertension or type 2 diabetes mellitus (T2DM),
Exclusion Criteria
20 Years
75 Years
ALL
No
Sponsors
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Assiut University
OTHER
Responsible Party
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Shimaa Abo Bakr Ahmed Mahmoud
specialist( M. Sc)in Gastroenterology and Infectious Diseases Faculty of Medicine, Assiut University
Central Contacts
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References
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Di Palma A, Alhabdan S, Maeda A, Mattu F, Chetty R, Serra S, Quereshy F, Jackson T, Okrainec A. Unexpected histopathological findings after sleeve gastrectomy. Surg Endosc. 2020 May;34(5):2158-2163. doi: 10.1007/s00464-019-07002-7. Epub 2019 Sep 11.
Papasavas P, Seip RL, Stone A, Staff I, McLaughlin T, Tishler D. Robot-assisted sleeve gastrectomy and Roux-en-y gastric bypass: results from the metabolic and bariatric surgery accreditation and quality improvement program data registry. Surg Obes Relat Dis. 2019 Aug;15(8):1281-1290. doi: 10.1016/j.soard.2019.04.003. Epub 2019 Apr 13.
Other Identifiers
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Bariatric Surgery in NAFLD
Identifier Type: -
Identifier Source: org_study_id
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