What Lies Beneath the Stone? Metabolic Insights From Composition-Based Analysis of Kidney Stones

NCT ID: NCT06992206

Last Updated: 2025-05-28

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 506 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2010-01-01
• Study Completion Date: 2024-12-31

Brief Summary

This retrospective observational study investigates the metabolic abnormalities associated with different types of kidney stones by analyzing their composition. The study includes adult patients diagnosed with urolithiasis, whose stone samples were analyzed using Fourier Transform Infrared (FTIR) spectroscopy. Clinical, biochemical, and 24-hour urine metabolic parameters were compared between first-time and recurrent stone formers, and among subtypes of calcium oxalate stones (monohydrate vs. dihydrate). The goal is to identify metabolic risk factors that contribute to stone formation and recurrence, and to provide insights for individualized prevention strategies.

Detailed Description

This retrospective study aims to evaluate the metabolic characteristics of patients with urolithiasis based on kidney stone composition. Data were collected from patients treated for kidney stones between January 2010 and December 2024 at a tertiary urology center. Stone analysis was performed using FTIR spectroscopy, classifying stones into subtypes including calcium oxalate monohydrate (COM), calcium oxalate dihydrate (COD), uric acid, and mixed types.

Serum levels of calcium, phosphorus, uric acid, creatinine, and parathyroid hormone (PTH), along with 24-hour urine values (calcium, oxalate, citrate, uric acid, volume, and pH), were recorded. The study primarily compares metabolic differences between:

First-time vs. recurrent stone formers

COM vs. COD stone subtypes

Findings from this study are expected to improve understanding of metabolic risk factors and contribute to the development of tailored metabolic evaluations and dietary or pharmacological preventive strategies for recurrent stone formers.

Conditions

Urolithiasis, Calcium Oxalate

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

First-time Stone Formers

Adult patients who presented with their first episode of kidney stone disease. These patients underwent stone composition analysis via FTIR spectroscopy and metabolic evaluation including serum and 24-hour urine testing to identify risk factors for initial stone formation.

Metabolik taş analizi ile retrospektif gözlem

Intervention Type: OTHER

This study did not involve an active intervention. It retrospectively analyzed medical records of 506 patients who underwent compositional analysis of kidney stones to identify metabolic abnormalities. The aim was to evaluate stone composition in relation to metabolic parameters such as serum and 24-hour urine values, without modifying patient treatment.

Recurrent Stone Formers

Patients with a documented history of recurrent kidney stone episodes. These individuals were evaluated to assess differences in metabolic profiles and stone composition compared to first-time stone formers, with the aim of identifying predictors of recurrence and optimizing preventive strategies.

Metabolik taş analizi ile retrospektif gözlem

Intervention Type: OTHER

This study did not involve an active intervention. It retrospectively analyzed medical records of 506 patients who underwent compositional analysis of kidney stones to identify metabolic abnormalities. The aim was to evaluate stone composition in relation to metabolic parameters such as serum and 24-hour urine values, without modifying patient treatment.

Interventions

Metabolik taş analizi ile retrospektif gözlem

This study did not involve an active intervention. It retrospectively analyzed medical records of 506 patients who underwent compositional analysis of kidney stones to identify metabolic abnormalities. The aim was to evaluate stone composition in relation to metabolic parameters such as serum and 24-hour urine values, without modifying patient treatment.

Intervention Type: OTHER

Other Intervention Names

Böbrek taşı kompozisyonu değerlendirmesi Retrospektif metabolik değerlendirme

Eligibility Criteria

Inclusion Criteria

• Age ≥ 18 years
• Patients diagnosed with kidney stones between January 2010 and December 2024
• Stone composition analyzed via Fourier-transform infrared (FTIR) spectroscopy
• Available metabolic panel including serum and 24-hour urine values

Exclusion Criteria

• Patients with secondary hyperparathyroidism, renal tubular acidosis, or other systemic metabolic diseases affecting stone formation
• Patients with incomplete medical records
• Patients with non-calcium-based stones (e.g., uric acid, struvite, cystine)

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Hisar Intercontinental Hospital

OTHER

Sponsor Role: lead

Responsible Party

Basri Cakiroglu

Prof.Dr

Responsibility Role: PRINCIPAL_INVESTIGATOR

Other Identifiers

Hisar-KSD-2025-33

Identifier Type: -

Identifier Source: org_study_id