Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
80 participants
OBSERVATIONAL
2023-10-31
2025-12-31
Brief Summary
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Detailed Description
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Our objectives are to determine whether
1. at diagnosis the following are predictive for response to food elimination:
1. history of atopy, symptoms after food intake
2. eosinophil counts in biopsies and peripheral blood
3. total IgE, specific IgE, eosinophilic granula proteins, eosinophil progenitor cells in blood
4. key cytokines (Eotaxin-3, IL-5, IL-13)
5. eosinophil derived neurotoxin/EDN in oesophageal aspirates, blood samples and feces
6. circulating microRNAs
2. at follow-up biomarkers collected by non-invasive methods can predict endoscopic and histologic healing
1. eosinophil counts in esophageal brushes and peripheral blood
2. total IgE, specific IgE, eosinophilic granula protein, eosinophil progenitor cells
3. circulating cytokines like eotaxin-3, IL-5, IL-13
4. eosinophil derived neurotoxin/EDN in esophageal brushes, blood samples and feces
5. circulating microRNAs
Conditions
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Study Design
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COHORT
PROSPECTIVE
Interventions
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Biobank sampling for new biomarkers
Using biopsies as the gold standard, the project aims towards validating non-invasive biomarkers as specified previously against biopsies.
Eligibility Criteria
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Inclusion Criteria
* suspected but not yet confirmed eosinophilic esophagitis
Exclusion Criteria
* lack of consent
17 Years
ALL
No
Sponsors
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Helse-Bergen HF
OTHER
Oslo University Hospital
OTHER
Responsible Party
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Ketil Størdal
Dr
Principal Investigators
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Ketil Størdal, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Oslo
Locations
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Haukeland University Hospital
Bergen, , Norway
OsloUH
Oslo, , Norway
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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201046
Identifier Type: -
Identifier Source: org_study_id
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