EoE RCT Fluticasone and Omeprazole vs Fluticasone Alone

NCT ID: NCT03781596

Last Updated: 2018-12-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE4

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-10-02

Study Completion Date

2022-10-02

Brief Summary

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The purpose of this study is to evaluate the efficacy of combination therapy with omeprazole and swallowed fluticasone vs fluticasone therapy and placebo in the treatment of Eosinophilic Esophagitis (EoE) in children and adults. This study will be a double-blinded, randomized controlled trial. The primary outcome measured will be histologic assessment of esophageal tissue biopsies measuring number of eosinophils per high power field (eos/hpf). Secondary outcomes will be endoscopic findings and symptomatic changes following therapy using validated endoscopic scoring measures and participant surveys, respectively.

Detailed Description

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Subjects that meet study inclusion criteria will be recruited from the Adult and Pediatric Gastroenterology clinics at Walter Reed National Military Medical Center through routine clinic visits, will meet with an investigator, and complete informed consent/assent. The participants will then complete a validated clinical symptom reporting tool - the Eosinophilic Esophagitis symptom activity index (EEsAI) for age 18 and above, or the Pediatric Quality of Life Inventory (PedsQL) for age 6-17yrs - and have their initial Esophagogastroduodenoscopy (EGD) images evaluated via a validated Endoscopic Reference Score (EREFS). Esophageal biopsies taken at the patient's initial EGD will be assessed by 2 designated blinded pathologists to record the number of eosinophils per high power field (HPF), as well as perform tissue immunohistochemical staining for eotaxin-3. Participants will be block randomized to treatment or control groups and complete 8 weeks of therapy, with a phone follow up at 4 weeks for medication compliance. At the completion of 8 weeks of therapy, the participants will have repeat EGD to assess for mucosal healing, which is the standard of care in the treatment of EoE. At this EGD, the images will be assigned an EREFS and the biopsies will be evaluated for eosinophils per high powered field and eotaxin-3 staining. The patient will also complete an EEsAI or PedsQL. This procedure will end the 8 week study period.

Conditions

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Eosinophilic Esophagitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Fluticasone and omeprazole

These patients will be prescribed swallowed fluticasone and omeprazole to be taken together for the 8 week period. Dosing will be based on weight and age. Primary outcome measure will be the change in esophageal biopsy histology, or number of eosinophils per high powered field, from week 0 to week 8. Secondary outcomes will include changes in the following variables between week 0 and 8: eotaxin staining of the esophageal biopsy tissue, endoscopic scoring from photos of the esophagus obtained during endoscopy, and symptom scoring based on surveys.

Group Type EXPERIMENTAL

Retrospective evaluation of endoscopy prior to study drug

Intervention Type DIAGNOSTIC_TEST

Once enrolled, the patient's original endoscopy will be evaluated including the images from the EGD and the biopsies for eotaxin 3 staining and eosinophilic burden.

Symptom Survey

Intervention Type OTHER

Patient will complete symptom survey prior to starting the study drugs.

Medication Compliance Phone Call

Intervention Type OTHER

The patient will receive a phone call at 4 weeks to evaluate medication compliance including the number on the inhaler and the number of pills remaining in the container.

Endoscopy while on study drug

Intervention Type DIAGNOSTIC_TEST

Endoscopy will be performed after 8 weeks of therapy. Endoscopic scoring will be assigned and the histology will be evaluated, including eotaxin 3 staining. The change in eosinophil count and eotaxin staining will be measured.

Symptom Survey

Intervention Type OTHER

The patient will complete a symptom survey after 8 weeks on the study drugs, and the change in survey score will be measured.

Fluticasone

Intervention Type DRUG

Participants in the experimental and placebo arms will be given swallowed fluticasone for an 8 week course. Doses determined by age and weight.

Omeprazole

Intervention Type DRUG

The participants in the experimental arm will be given oral omprazole capsules for an 8 week period (along with the swallowed fluticasone). Doses determined by age and weight.

Fluticasone and placebo

These patients will be prescribed swallowed fluticasone and a placebo medication that appears identical to omeprazole to be taken together for an 8 week period. Dosing will be based on weight and age. Primary outcome measure will be the change in esophageal biopsy histology, or number of eosinophils per high powered field, from week 0 to week 8. Secondary outcomes will include changes in the following variables between week 0 and 8: eotaxin staining of the esophageal biopsy tissue, endoscopic scoring from photos of the esophagus obtained during endoscopy, and symptom scoring based on surveys.

Group Type PLACEBO_COMPARATOR

Retrospective evaluation of endoscopy prior to study drug

Intervention Type DIAGNOSTIC_TEST

Once enrolled, the patient's original endoscopy will be evaluated including the images from the EGD and the biopsies for eotaxin 3 staining and eosinophilic burden.

Symptom Survey

Intervention Type OTHER

Patient will complete symptom survey prior to starting the study drugs.

Medication Compliance Phone Call

Intervention Type OTHER

The patient will receive a phone call at 4 weeks to evaluate medication compliance including the number on the inhaler and the number of pills remaining in the container.

Endoscopy while on study drug

Intervention Type DIAGNOSTIC_TEST

Endoscopy will be performed after 8 weeks of therapy. Endoscopic scoring will be assigned and the histology will be evaluated, including eotaxin 3 staining. The change in eosinophil count and eotaxin staining will be measured.

Symptom Survey

Intervention Type OTHER

The patient will complete a symptom survey after 8 weeks on the study drugs, and the change in survey score will be measured.

Fluticasone

Intervention Type DRUG

Participants in the experimental and placebo arms will be given swallowed fluticasone for an 8 week course. Doses determined by age and weight.

Placebo oral capsule

Intervention Type DRUG

The participants in the placebo arm will be given placebo capsules for an 8 week period (along with the swallowed fluticasone). Number of pills determined by age and weight (to match omeprazole dosing).

Interventions

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Retrospective evaluation of endoscopy prior to study drug

Once enrolled, the patient's original endoscopy will be evaluated including the images from the EGD and the biopsies for eotaxin 3 staining and eosinophilic burden.

Intervention Type DIAGNOSTIC_TEST

Symptom Survey

Patient will complete symptom survey prior to starting the study drugs.

Intervention Type OTHER

Medication Compliance Phone Call

The patient will receive a phone call at 4 weeks to evaluate medication compliance including the number on the inhaler and the number of pills remaining in the container.

Intervention Type OTHER

Endoscopy while on study drug

Endoscopy will be performed after 8 weeks of therapy. Endoscopic scoring will be assigned and the histology will be evaluated, including eotaxin 3 staining. The change in eosinophil count and eotaxin staining will be measured.

Intervention Type DIAGNOSTIC_TEST

Symptom Survey

The patient will complete a symptom survey after 8 weeks on the study drugs, and the change in survey score will be measured.

Intervention Type OTHER

Fluticasone

Participants in the experimental and placebo arms will be given swallowed fluticasone for an 8 week course. Doses determined by age and weight.

Intervention Type DRUG

Omeprazole

The participants in the experimental arm will be given oral omprazole capsules for an 8 week period (along with the swallowed fluticasone). Doses determined by age and weight.

Intervention Type DRUG

Placebo oral capsule

The participants in the placebo arm will be given placebo capsules for an 8 week period (along with the swallowed fluticasone). Number of pills determined by age and weight (to match omeprazole dosing).

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* age 6 to 60 years old
* DEERS (defense enrollment eligibility reporting system) eligible
* diagnosis of eosinophilic esophagitis

Exclusion Criteria

* Outside of age range
* Co-existing inflammatory gastroenterologic condition such as celiac disease, eosinophilic esophagitis, or inflammatory bowel disease.
* Concurrent use of oral steroids
* Pregnancy
* Refusal to undergo endoscopy
Minimum Eligible Age

6 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Claire Daniels

FED

Sponsor Role lead

Responsible Party

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Claire Daniels

Associate Investigator

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Walter Reed National Military Medical Center

Bethesda, Maryland, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Steve B Min, M.D.

Role: CONTACT

Phone: 301-295-4959

Email: [email protected]

Claire P Daniels, M.D.

Role: CONTACT

Phone: 301-295-4959

Email: [email protected]

Facility Contacts

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Claire P Daniels, M.D.

Role: primary

References

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Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

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WRNMMC-2018-0133

Identifier Type: -

Identifier Source: org_study_id