Investigating the Effectiveness of a 2-week Novel Non-invasive Brain Stimulation Technique on Cognitive Outcomes in Healthy Adults
NCT ID: NCT06991764
Last Updated: 2025-05-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
120 participants
INTERVENTIONAL
2025-06-01
2027-04-30
Brief Summary
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1. Would a single session of anodal tPCS over the left prefrontal cortex improve working memory, task inhibition, and task switching in healthy young and older adults, compared to anodal transcranial direct current stimulation (tDCS) and sham-tPCS?
2. Would repeated session of anodal-tPCS (2-weeks) lead to improvements in working memory, task inhibition, and task switching in healthy young and older adults, compared to tDCS and sham-tPCS?
3. Will tPCS be better tolerated among healthy adults, compared to tDCS?
Researchers will compare tPCS / tDCS / sham-tPCS to see if there are any differences in cognitive outcomes after 1 session and after repeated sessions, as well as to compare the tolerance of tPCS against tDCS and sham-tPCS.
Participants will be requested to:
* Undergo 1 of 3 of the following conditions: tDCS / tPCS / sham-tPCS
* Complete three sessions of cognitive tasks testing working memory, inhibition and task switching at baseline (pre-stimulation), after day 1 of brain stimulation and after 10 sessions of brain stimulation (post- repeated stimulation)
* Undergo fNIRS-EEG brain measurements concurrently with the cognitive tasks
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Detailed Description
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Cognitive tasks will be administered at baseline, after 1 session of stimulation and after 10 sessions of stimulation (post-stimulation). These cognitive tasks consist of a working memory task (1/2/3 back tasks), a cognitive inhibition task (go/no-go task) and a cognitive flexibility task (Stroop task). Concurrent with the cognitive task will be the administration of fNIRS-EEG recording to measure changes in brain activation and patterns during the tasks.
The experiment will take place in the Motor Behaviour Lab at the National Institute of Education, Nanyang Technological University in Singapore.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
TRIPLE
Study Groups
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Transcranial Direct Current Stimulation (tDCS)
In this condition, current intensity will be maintained between 0.6 to 0.7 mA for 20 minutes.
Non-Invasive Brain Stimulation (tDCS / tPCS / sham-tPCS)
This is a novel non-invasive brain stimulation technique that we hope to be investigating, and this technique will be compared with an active control (tDCS) and a control (sham-tPCS).
High Frequency Transcranial Pulsed Current Stimulation (HF-tPCS)
In this condition, current will be introduced in pulses with intensity consistent between 0.6 to 0.7 mA. The duration of the stimulation is 20 minutes.
Non-Invasive Brain Stimulation (tDCS / tPCS / sham-tPCS)
This is a novel non-invasive brain stimulation technique that we hope to be investigating, and this technique will be compared with an active control (tDCS) and a control (sham-tPCS).
Sham-tPCS
In this condition, there will be a 30 seconds ramp-up phase to a current intensity between 0.6 to 0.7 mA followed by a 30 seconds ramp-down phase to 0 mA. The participant will, however, remain seated with the set-up for the remaining time until 20 minutes is up.
Non-Invasive Brain Stimulation (tDCS / tPCS / sham-tPCS)
This is a novel non-invasive brain stimulation technique that we hope to be investigating, and this technique will be compared with an active control (tDCS) and a control (sham-tPCS).
Interventions
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Non-Invasive Brain Stimulation (tDCS / tPCS / sham-tPCS)
This is a novel non-invasive brain stimulation technique that we hope to be investigating, and this technique will be compared with an active control (tDCS) and a control (sham-tPCS).
Eligibility Criteria
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Inclusion Criteria
* Right-handed
* Must be a native English speaker
* No clinical diagnosis of neurodevelopmental, mood, neurological or neurodegenerative disorders
* Adults with cardiometabolic or cardiovascular conditions may participate if their condition is controlled and stable with medication and / or lifestyle interventions
Exclusion Criteria
* Adults with metallic implants in the chest or head region
* Adults with epilepsy, or known seizure or immediate family members that have had a seizure before
* Had a recent head injury that resulted in a temporary loss of consciousness or of memory in the last 12 months
* Had prior head surgery
* Prone to fainting
* Sensitive skin or prone to skin allergies
21 Years
75 Years
ALL
Yes
Sponsors
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Ministry of Education, Singapore
OTHER_GOV
National Institute of Education, Singapore
OTHER
Nanyang Technological University
OTHER
Responsible Party
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Teo Wei Peng
Associate Professor
Principal Investigators
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Wei Peng Teo, Associate Professor
Role: PRINCIPAL_INVESTIGATOR
National Institute of Education, Nanyang Technological University, Singapore
Central Contacts
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Other Identifiers
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IRB-2025-003
Identifier Type: -
Identifier Source: org_study_id
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