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Extent of Lymph Node Dissecti...

Extent of Lymph Node Dissection for Advanced Right-Sided Colon Cance

Last Updated: 2025-05-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

Total Enrollment

1064 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-06-01

Study Completion Date

2029-12-31

Brief Summary

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This is a prospective multicenter randomized controlled clinical study to explore the extent of lymph node dissection in progressive right hemicolon cancer and to elucidate the pattern of lymphatic drainage in the right hemicolon.

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Detailed Description

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Conditions

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Advanced Right-sided Colon Cancer the Extent of Lymph Node Dissection

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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SMV group

Group Type ACTIVE_COMPARATOR

Clearance with the left side of the SMV as the medial boundary

Intervention Type PROCEDURE

Undergo radical resection for right colon cancer with the left side of the SMV as the medial boundary

SMA group

Group Type EXPERIMENTAL

Clearance with the left side of the SMA as the medial boundary

Intervention Type PROCEDURE

Undergo radical resection for right colon cancer with the left side of the SMA as the medial boundary

Interventions

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Clearance with the left side of the SMV as the medial boundary

Undergo radical resection for right colon cancer with the left side of the SMV as the medial boundary

Intervention Type PROCEDURE

Clearance with the left side of the SMA as the medial boundary

Undergo radical resection for right colon cancer with the left side of the SMA as the medial boundary

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

1. Age: 18-75 years
2. Preoperative pathologic confirmation of adenocarcinoma
3. Tumor located in the region from the ileocecal valve to the right one-third of the transverse colon
4. American Society of Anesthesiologists (ASA) physical status classification I to III
5. Patients who have not received preoperative radiotherapy, chemotherapy, or immunotherapy
6. Preoperative imaging staging cT4N0M0 or cT3-4N+M0
7. Willing to participate in the study and sign the informed consent form

Exclusion Criteria

1. Past medical history of malignant tumor
2. Patients with multiple primary tumors
3. Patients with a history of inflammatory bowel disease or familial adenomatous polyposis
4. Patients with distant metastasis
5. Pregnant or breastfeeding women
6. History of other previous major abdominal surgery
7. Patients requiring emergency surgery (including tumor perforation, obstruction, hemorrhage, etc.)
8. Those with other clinical and laboratory conditions deemed by the investigator to be inappropriate for participation in the trial

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers