Genetic Markers of Diabetic Ulcers and Personalized Treatment Targets Research

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

712 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-05-16

Study Completion Date

2027-05-16

Brief Summary

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This clinical trial involves collecting peripheral blood, ulcer tissue, and fecal samples from diabetic ulcer patients for bioinformatics analysis to screen genetic markers significantly associated with ulcer risk and healing differences. Furthermore, multi-omics data will be integrated to establish a diabetic ulcer risk prediction model. Based on key single nucleotide polymorphisms and their regulatory pathways, potential new drug targets for promoting healing will be explored, providing a genetic basis for personalized treatment.

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Detailed Description

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Conditions

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Diabetic Ulcers

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* 1\) Subjects who voluntarily participate in this clinical study and sign informed consent;
* 2\) Patients with type 2 diabetes and diabetic ulcers;
* 3\) Disease duration ≥ 10 years or age ≥ 55 years at enrollment;
* 4\) Inpatient or outpatient who can be monitored by the same investigating team throughout the duration of the study.

Exclusion Criteria

* 1\) Severe vascular occlusion or impairment;
* 2\) Patients with congenital heart disease, aortic dissection, or other severe cardiovascular diseases;
* 3\) Patients with ulcers caused by factors other than diabetes;
* 4\) Patients with severe liver and kidney dysfunction or serious neurological impairment.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No