Physical Activity in Adolescents With Familial Mediterranean Fever

NCT ID: NCT06974942

Last Updated: 2025-05-16

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 172 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-05-15
• Study Completion Date: 2025-11-15

Brief Summary

Familial Mediterranean Fever (FMF) is one of the most common autoinflammatory rheumatic diseases in childhood. Problems such as joint pain, muscle weakness, decreased aerobic capacity, and fatigue seen in children and adolescents with rheumatic disease may lead to low physical fitness levels. Limitation of physical performance is one of the possible consequences of chronic diseases that occur during childhood. At the same time, children with chronic illness face many challenges in participating in physical activity. Pediatric patients with rheumatic diseases tend to be physically inactive and, compared to their healthy peers, generally avoid participating in physical activity due to the limitations imposed by the disease. Often, the disease itself paves the way for decreased functional capacity and the development of deconditioning. Therefore, prescribing physical activity and exercise to pediatric populations with chronic illnesses is of great importance. This approach helps alleviate both the symptoms related to chronic diseases and the lifelong complications secondary to pharmacological treatments, and also prevents the development of new chronic conditions.

Participation in adequate physical activity is one of the most important behaviors individuals can adopt to maintain their health and well-being. Globally, public health physical activity guidelines address the exercise needs of children and adolescents. The European Alliance of Associations for Rheumatology (EULAR) highlights in its physical activity and exercise guidelines for patients with rheumatic diseases that the physical activity recommendations made for the general population are also applicable to patients with rheumatic diseases.

With this cohort study, it is aimed to examine physical activity (PA) in detail in adolescents diagnosed with FMF and to compare them with healthy peers. This study is one of the first in our country to provide comprehensive data on the PA levels of adolescents with FMF. The findings obtained will contribute to understanding PA levels and exercise perception, and guide the planning of exercise programs to be developed for these individuals. Moreover, the results of the study may also serve as a basis for future research in children and adolescents with various chronic diseases, especially those with FMF.

Conditions

Familial Mediterranean Fever (FMF )

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Familial Mediterranean Fever

The study will include 76 patients diagnosed with Familial Mediterranean Fever who are being followed at the Division of Pediatric Rheumatology, Department of Pediatrics, Istanbul Faculty of Medicine, Istanbul University.

No interventions assigned to this group

Healthy control

The study will include healthy peers of adolescents diagnosed with FMF.

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Be between 12-18 years of age
• Have been diagnosed with FMF for at least 6 months at the Pediatric Rheumatology Department of Istanbul Faculty of Medicine
• Be undergoing routine medical treatment for FMF
• Be willing to participate in the study

• Be between 12-18 years of age
• Be willing to participate in the study

Exclusion Criteria

• Adolescents whose participation in the study is not wanted by their family
• Having vestibular or neurological balance problems
• Presence of scoliosis, leg length discrepancy, or recent lower extremity surgery
• Adolescents with visual or hearing impairments

• Adolescents whose participation in the study is not wanted by their family
• Having vestibular or neurological balance problems
• Presence of scoliosis, leg length discrepancy, or recent lower extremity surgery
• Adolescents with visual or hearing impairments

• Leaving at least 3 questions unanswered in the questionnaires

• Minimum Eligible Age: 12 Years
• Maximum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Istanbul University - Cerrahpasa

OTHER

Sponsor Role: lead

Responsible Party

Nilay Arman

PhD

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Istanbul University-Cerrahpasa

Istanbul, , Turkey (Türkiye)

Countries

Turkey (Türkiye)

Central Contacts

Nilay Arman, PhD

Role: CONTACT

nilayarman@iuc.edu.tr

0553 455 87 07

Asya Albayrak, MSc

Role: CONTACT

0538 396 89 50

Other Identifiers

paqfmf

Identifier Type: -

Identifier Source: org_study_id