Effect of Vestibular Exercises on Post-Stroke Fatigue

NCT ID: NCT06956183

Last Updated: 2025-12-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-06-15

Study Completion Date

2026-03-26

Brief Summary

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The goal of this clinical trial is to search effects of vestibuler exercises on post-stroke fatigue. The main question it aims to answer is:

wer are:

\- Do vestibuler excercises decrease post-stroke perceived and physiologic fatigue?

Researchers will compare the effects of vestibuler exercises to conventional rehabilitation to find out the superior one.

Participants will:

* take a one-hour conventional rehabilitation or vestibuler exercise program three times in a week.
* be assessed in terms of fatigue before and after rehabilitation programs.

Detailed Description

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One of the most common complications after stroke is fatigue. Fatigue prolongs the rehabilitation period and delays recovery. Although medical treatments, exercise programs and activity modifications are recommended to reduce fatigue after stroke, an effective evidence-based treatment method has not yet been developed. Vestibular exercises can improve oculomotor and postural control by trying to provide sensory integration through adaptation and compensatory mechanisms, thus increasing cortical excitability and reducing fatigue.

Conditions

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Stroke

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Randomized Controlled
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Control group

Participants in the control group will participate in a one-hour conventional exercise program three times a week for eight weeks.

Group Type OTHER

Control (Standard treatment)

Intervention Type OTHER

In control group participants will take one hour conventional physiotherapy including stretching, strengthening, balance and gait exercises in each session.

Vestibular Group

In vestibular group (study group) participants in the study group will receive 20 minutes of vestibular training in addition to a 40-minute conventional exercise program, three times a week for eight weeks.

Group Type EXPERIMENTAL

Vestibular exercise

Intervention Type OTHER

In vestibular group (study group) participant will take 40 minutes conventional physiotherapy including stretching, strengthening, balance and gait exercises, and 20 minutes vestibular exercises including head and gaze stabilization, occulomotor, head turning and balance exercises in different postures.

Interventions

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Control (Standard treatment)

In control group participants will take one hour conventional physiotherapy including stretching, strengthening, balance and gait exercises in each session.

Intervention Type OTHER

Vestibular exercise

In vestibular group (study group) participant will take 40 minutes conventional physiotherapy including stretching, strengthening, balance and gait exercises, and 20 minutes vestibular exercises including head and gaze stabilization, occulomotor, head turning and balance exercises in different postures.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Volunteering to participate in the study Being between the ages of 18-65 Having had an anterior circulation stroke at least 6 months ago Being at least stage 3 according to the Functional Ambulation Classification Scoring at least 22 on the Montreal Cognitive Assessment Scale

Exclusion Criteria

* Having another orthopedic, neurological or other systemic disease that prevents working Having severe aphasia Having a disease other than stroke that causes primary fatigue Using medication that will affect cognitive status Using medication that will affect fatigue
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hacettepe University

OTHER

Sponsor Role lead

Responsible Party

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ayla fil balkan

associate professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Hacettepe University

Ankara, , Turkey (Türkiye)

Site Status NOT_YET_RECRUITING

Hacettepe University

Ankara, , Turkey (Türkiye)

Site Status RECRUITING

Countries

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Turkey (Türkiye)

Central Contacts

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Ayla Fil Balkan, Assoc Prof

Role: CONTACT

+903123051572

Facility Contacts

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Ayla Fil Balkan, Assoc Prof

Role: primary

+905354549027

AYLA FİL BALKAN, Assoc.Prof. PhD

Role: primary

+905074708330

References

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Oppenlander K, Utz KS, Reinhart S, Keller I, Kerkhoff G, Schaadt AK. Subliminal galvanic-vestibular stimulation recalibrates the distorted visual and tactile subjective vertical in right-sided stroke. Neuropsychologia. 2015 Jul;74:178-83. doi: 10.1016/j.neuropsychologia.2015.03.004. Epub 2015 Mar 3.

Reference Type BACKGROUND
PMID: 25744870 (View on PubMed)

Ghaffari A, Asadi B, Zareian A, Akbarfahimi M, Raissi GR, Fathali Lavasani F. The Effects of Vestibular Rehabilitation on Poststroke Fatigue: A Randomized Controlled Trial Study. Stroke Res Treat. 2022 Aug 31;2022:3155437. doi: 10.1155/2022/3155437. eCollection 2022.

Reference Type BACKGROUND
PMID: 36090743 (View on PubMed)

Mitsutake T, Sakamoto M, Ueta K, Oka S, Horikawa E. Effects of vestibular rehabilitation on gait performance in poststroke patients: a pilot randomized controlled trial. Int J Rehabil Res. 2017 Sep;40(3):240-245. doi: 10.1097/MRR.0000000000000234.

Reference Type BACKGROUND
PMID: 28542112 (View on PubMed)

Angelaki DE, Klier EM, Snyder LH. A vestibular sensation: probabilistic approaches to spatial perception. Neuron. 2009 Nov 25;64(4):448-61. doi: 10.1016/j.neuron.2009.11.010.

Reference Type BACKGROUND
PMID: 19945388 (View on PubMed)

Tramontano M, Bergamini E, Iosa M, Belluscio V, Vannozzi G, Morone G. Vestibular rehabilitation training in patients with subacute stroke: A preliminary randomized controlled trial. NeuroRehabilitation. 2018;43(2):247-254. doi: 10.3233/NRE-182427.

Reference Type BACKGROUND
PMID: 30040765 (View on PubMed)

Su Y, Yuki M, Otsuki M. Non-Pharmacological Interventions for Post-Stroke Fatigue: Systematic Review and Network Meta-Analysis. J Clin Med. 2020 Feb 25;9(3):621. doi: 10.3390/jcm9030621.

Reference Type BACKGROUND
PMID: 32106490 (View on PubMed)

Paciaroni M, Acciarresi M. Poststroke Fatigue. Stroke. 2019 Jul;50(7):1927-1933. doi: 10.1161/STROKEAHA.119.023552. Epub 2019 Jun 14. No abstract available.

Reference Type BACKGROUND
PMID: 31195940 (View on PubMed)

Bernard-Espina J, Beraneck M, Maier MA, Tagliabue M. Multisensory Integration in Stroke Patients: A Theoretical Approach to Reinterpret Upper-Limb Proprioceptive Deficits and Visual Compensation. Front Neurosci. 2021 Apr 7;15:646698. doi: 10.3389/fnins.2021.646698. eCollection 2021.

Reference Type BACKGROUND
PMID: 33897359 (View on PubMed)

Oliveira CB, Medeiros IR, Greters MG, Frota NA, Lucato LT, Scaff M, Conforto AB. Abnormal sensory integration affects balance control in hemiparetic patients within the first year after stroke. Clinics (Sao Paulo). 2011;66(12):2043-8. doi: 10.1590/s1807-59322011001200008.

Reference Type BACKGROUND
PMID: 22189728 (View on PubMed)

Jang SH, Lee JH. Impact of sensory integration training on balance among stroke patients: sensory integration training on balance among stroke patients. Open Med (Wars). 2016 Aug 13;11(1):330-335. doi: 10.1515/med-2016-0061. eCollection 2016.

Reference Type BACKGROUND
PMID: 28352817 (View on PubMed)

Sharony AF, Engel-Yeger B. Sensory Modulation and Participation in Daily Occupations in Stroke Survivors. Can J Occup Ther. 2021 Dec;88(4):375-383. doi: 10.1177/00084174211047372. Epub 2021 Oct 9.

Reference Type BACKGROUND
PMID: 34632801 (View on PubMed)

Schambra HM, Sawaki L, Cohen LG. Modulation of excitability of human motor cortex (M1) by 1 Hz transcranial magnetic stimulation of the contralateral M1. Clin Neurophysiol. 2003 Jan;114(1):130-3. doi: 10.1016/s1388-2457(02)00342-5.

Reference Type BACKGROUND
PMID: 12495773 (View on PubMed)

Plewnia C, Lotze M, Gerloff C. Disinhibition of the contralateral motor cortex by low-frequency rTMS. Neuroreport. 2003 Mar 24;14(4):609-12. doi: 10.1097/00001756-200303240-00017.

Reference Type BACKGROUND
PMID: 12657896 (View on PubMed)

Kluger BM, Krupp LB, Enoka RM. Fatigue and fatigability in neurologic illnesses: proposal for a unified taxonomy. Neurology. 2013 Jan 22;80(4):409-16. doi: 10.1212/WNL.0b013e31827f07be.

Reference Type BACKGROUND
PMID: 23339207 (View on PubMed)

Ponchel A, Bombois S, Bordet R, Henon H. Factors Associated with Poststroke Fatigue: A Systematic Review. Stroke Res Treat. 2015;2015:347920. doi: 10.1155/2015/347920. Epub 2015 May 25.

Reference Type BACKGROUND
PMID: 26101691 (View on PubMed)

McGeough E, Pollock A, Smith LN, Dennis M, Sharpe M, Lewis S, Mead GE. Interventions for post-stroke fatigue. Cochrane Database Syst Rev. 2009 Jul 8;(3):CD007030. doi: 10.1002/14651858.CD007030.pub2.

Reference Type BACKGROUND
PMID: 19588416 (View on PubMed)

Nadarajah M, Goh HT. Post-stroke fatigue: a review on prevalence, correlates, measurement, and management. Top Stroke Rehabil. 2015 Jun;22(3):208-20. doi: 10.1179/1074935714Z.0000000015. Epub 2015 Mar 17.

Reference Type BACKGROUND
PMID: 25779764 (View on PubMed)

Other Identifiers

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KA-23056

Identifier Type: -

Identifier Source: org_study_id

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