Mechanisms of Myocardial Injury and Ischemia in Patients With Rapid Atrial Fibrillation
NCT ID: NCT06951100
Last Updated: 2025-06-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
300 participants
OBSERVATIONAL
2025-05-01
2029-10-31
Brief Summary
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The main questions this study aims to answer are:
1. Are patients with a fast, irregular heartbeat (rapid AF) and damage to the heart (myocardial injury) more likely than those without damage to the heart to have blocked heart arteries (obstructive coronary artery disease)
2. Are patients with a fast, irregular heartbeat (rapid AF) and damage to the heart (myocardial injury) with further evidence that their heart hasn't been getting enough oxygen (myocardial ischemia) more likely to have imaging evidence of myocardial infarction than those without myocardial ischemia
To do this, we will measure troponin in patients with rapid AF and then carry out further investigations of the heart (electrocardiogram, echocardiogram, CT scan and cardiac MRI)
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Interventions
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CT coronary angiography
To assess the presence of obstructive coronary artery disease, participants will either have coronary angiography as part of their routine care or they will return for a research CT scan of their heart (CT Coronary Angiogram)
Eligibility Criteria
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Inclusion Criteria
2. Primary presentation with symptoms related to atrial fibrillation
3. Atrial fibrillation with a ventricular rate \>100 bpm on a 12-lead electrocardiogram
4. Able to provide informed consent
Exclusion Criteria
2. Previous coronary revascularisation procedure
3. Patients in renal failure (eGFR \<30ml/min/1.73m2) or major allergy to contrast media
4. Pregnancy or breast feeding
5. Deemed unsuitable for participation in the study by the attending clinician
6. Previous enrolment in the trial
18 Years
ALL
No
Sponsors
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British Heart Foundation
OTHER
NHS Lothian
OTHER_GOV
University of Edinburgh
OTHER
Responsible Party
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Locations
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Royal Infirmary of Edinburgh
Edinburgh, East of England, United Kingdom
Countries
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Facility Contacts
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Other Identifiers
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25-SS-0009
Identifier Type: OTHER
Identifier Source: secondary_id
AC24081
Identifier Type: -
Identifier Source: org_study_id
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