The Impact of Routine Measurement of Cardiac Troponin (hsTnT) on Outcome in Elderly Patients Undergoing Major Surgery

NCT ID: NCT03605134

Last Updated: 2025-11-18

Basic Information

• Recruitment Status: TERMINATED
• Total Enrollment: 63 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2018-08-23
• Study Completion Date: 2019-08-07

Brief Summary

To document levels of cardiac troponin hsTnT in patients above 75y undergoing high risk surgery and the relationship between elevated levels and outcome in terms of hospital stay and 30 day mortality.

Detailed Description

Elevated troponin (Tn) hsTnT levels occur as a result of myocardial damage and are used in the diagnosis of myocardial infarction (MI). However, there are multiple different causes that also result in abnormal Tn levels, such as direct myocardial-cell injury, impaired renal excretion and sepsis. Because of this, elevated Tn level is a common finding in hospitalized patients.

Several studies on patients admitted to the intensive care unit (ICU) without MI show that Tn elevation is a mortality risk factor and an independent predictor of hospital mortality.

Up till now it is not yet known if the routine measurement of Tn in elderly patients undergoing surgery can significantly improve their outcome and that is the primary aim of this study. In addition, it is not known what the impact could be if a diastolic function assessment could be performed peri-operatively.

This study will examine the correlation between elevated Tn levels in elderly patients undergoing major surgery and their short-term outcome (in-hospital). Before and immediately after surgery, diastolic function will be assessed by means of transthoracic echocardiography (TTE).

Conditions

Surgery--Complications; Mortality; Elderly

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

study group

level of cardiac troponin and diastolic function assessment by means of transthoracic echocardiography

level of cardiac troponin

Intervention Type: DIAGNOSTIC_TEST

blood test

diastolic function assessment

Intervention Type: DIAGNOSTIC_TEST

transthoracic echocardiography

Interventions

level of cardiac troponin

blood test

Intervention Type: DIAGNOSTIC_TEST

diastolic function assessment

transthoracic echocardiography

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• All patients ≥75 y undergoing elective and major surgery till we have collected an entire dataset of 100 patients.
• Only those patients will be included who are planned for elective and major surgery.

Exclusion Criteria

• Patients under the age of 75
• Intraoperative mortality
• Eye surgery
• Cardiac or thoracic surgery
• Patients undergoing surgery which is not withheld as major surgery
• For patients undergoing multiple surgeries for the same indication and during the same hospitalization, only the first surgery will be included

• Minimum Eligible Age: 75 Years
• Maximum Eligible Age: 100 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Universitair Ziekenhuis Brussel

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

jan Poelaert, PhD, MD

Role: PRINCIPAL_INVESTIGATOR

Universitair Ziekenhuis Brussel

Patrice Forget, PhD, MD

Role: STUDY_CHAIR

Universitair Ziekenhuis Brussel

Locations

Universitair Ziekenhuis Brussel

Jette, Vlaams Brabant, Belgium

Countries

Belgium

Other Identifiers

Troponin

Identifier Type: -

Identifier Source: org_study_id