Impact of Hospitalization on High-sensitivity Cardiac Troponin T Concentrations Depending on Disease Severity

NCT ID: NCT04963400

Last Updated: 2024-04-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

177 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-07-14

Study Completion Date

2024-01-17

Brief Summary

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We aim to examine, whether hospitalization is associated with higher high-sensitivity cardiac troponin T (hs-cTnT) serum concentrations in patients without a cardiac disease.

Detailed Description

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High-sensitivity cardiac troponin T (hs-cTnT) values will be obtained in hospitalized patients a) without a diagnosed or suspected cardiac disease, and b) with an acute medical condition that is not commonly associated with an increase of hs-cTnT concentrations. As a reference, a second sampling of blood for an analysis of the hs-cTnT serum concentration will be obtained in the same patients after discharge (60 days after hospitalization).

Conditions

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Non-cardiac Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients with low disease severity

Hospitalized patients without a diagnosed or suspected cardiac disease and with an acute medical condition of low severity (e.g. patients with retinal detachment)

Analysis of hs-cTnT serum concentration at hospitalization

Intervention Type DIAGNOSTIC_TEST

Analysis of the hs-cTnT serum concentration in the blood drawn at the day of hospitalization

Analysis of hs-cTnT serum concentration after discharge

Intervention Type DIAGNOSTIC_TEST

Analysis of the hs-cTnT serum concentration in the blood drawn after discharge (60 days after hospitalization)

Patients with medium disease severity

Hospitalized patients without a diagnosed or suspected cardiac disease and with an acute medical condition of medium severity (e.g. patients with an uncomplicated acute pancreatitis oder an acute exacerbation of a chronic inflammatory bowel disease)

Analysis of hs-cTnT serum concentration at hospitalization

Intervention Type DIAGNOSTIC_TEST

Analysis of the hs-cTnT serum concentration in the blood drawn at the day of hospitalization

Analysis of hs-cTnT serum concentration after discharge

Intervention Type DIAGNOSTIC_TEST

Analysis of the hs-cTnT serum concentration in the blood drawn after discharge (60 days after hospitalization)

Patients with high disease severity

Hospitalized patients without a diagnosed or suspected cardiac disease and with an acute medical condition of high severity (e.g. patients with a proximal femoral fracture)

Analysis of hs-cTnT serum concentration at hospitalization

Intervention Type DIAGNOSTIC_TEST

Analysis of the hs-cTnT serum concentration in the blood drawn at the day of hospitalization

Analysis of hs-cTnT serum concentration after discharge

Intervention Type DIAGNOSTIC_TEST

Analysis of the hs-cTnT serum concentration in the blood drawn after discharge (60 days after hospitalization)

Interventions

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Analysis of hs-cTnT serum concentration at hospitalization

Analysis of the hs-cTnT serum concentration in the blood drawn at the day of hospitalization

Intervention Type DIAGNOSTIC_TEST

Analysis of hs-cTnT serum concentration after discharge

Analysis of the hs-cTnT serum concentration in the blood drawn after discharge (60 days after hospitalization)

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* hospitalization due to a non-cardiac disease
* age ≥ 50 years

Exclusion Criteria

* diagnosed or suspected cardiac disease
* acute medical conditions commonly associated with a myocardial injury (e.g. circulatory shock, sepsis, pulmonary embolism, cerebral infarction, acute renal failure)
Minimum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Leipzig

OTHER

Sponsor Role lead

Responsible Party

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Rolf Wachter

Professor MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University of Leipzig Medical Center

Leipzig, , Germany

Site Status

Countries

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Germany

Other Identifiers

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RL_2021_1

Identifier Type: -

Identifier Source: org_study_id

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