Effect of Dual-Task Training and Cognitive Rehabilitation in Individuals With Multiple Sclerosis.

NCT ID: NCT06949696

Last Updated: 2025-04-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-04-20

Study Completion Date

2026-06-01

Brief Summary

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The purpose of this study is to examine the effects of dual-task training and cognitive rehabilitation on gait, balance, fatigue and cognitive performance in individuals with multiple sclerosis.

Detailed Description

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Multiple sclerosis (MS) is a complex disease characterized by chronic, inflammatory, demyelinating and neurodegenerative processes of the central nervous system (CNS) with heterogeneous clinical symptoms. Balance, gait and cognitive impairment are among the biggest problems in individuals with MS and significantly affect their daily lives.

Dual Task (DT); is the process of performing two tasks that can be performed independently and have different purposes simultaneously. Walking with dual tasks has recently been shown to resemble typical walking performance in daily life, thus providing clinicians with a realistic walking performance measurement in daily life. Although the effects of dual task performance in various neurological diseases have been partially described in the literature, the comparison of dual task training and cognitive rehabilitation on walking, balance, fatigue and cognitive performance has not been made and due to this deficiency in the literature, our study was planned and has originality. The aim of our study is to investigate the effects of dual task training and cognitive rehabilitation on walking, balance, fatigue and cognitive performance in individuals with MS.

Conditions

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Multiple Sclerosis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Comparison of 3 different physiotherapy groups(dual task training group, cognitive rehabilitation group, conventional physical therapy group)
Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors
A randomized, single-blind, controlled trial comparing a dual-task training group, a cognitive rehabilitation group, and a conventional physical therapy group.

Study Groups

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Dual Task Training Group

The dual task training group will receive training 2 days a week for 6 weeks. Patients will receive dual task training. They will also receive 30 minutes of individual physiotherapy exercises. 2 days a week. The effects of dual task training and cognitive rehabilitation on gait, balance, fatigue and cognitive performance will be compared.

Group Type EXPERIMENTAL

Dual Task Training

Intervention Type OTHER

In dual task training, patients will be given cognitive exercises such as counting backwards from 100 by 3, counting the names of cities, girls and boys while walking.

Cognitive Rehabilitation Group

The cognitive rehabilitation group will receive training 2 days a week for 6 weeks. Patients will receive cognitive rehabilitation group. They will also receive 30 minutes of individual physiotherapy exercises 2 days a week.

Group Type EXPERIMENTAL

Cognitive Rehabilitation

Intervention Type OTHER

In cognitive rehabilitation, patients will be given paper-and-pencil activities and exercises to find the difference between two pictures.

Conventionel Physiotherapy Group

The conventionel physiotherapy group will receive training 2 days a week for 6 weeks.This group will only receive individual physiotherapy 2 days a week.

Group Type ACTIVE_COMPARATOR

Conventionel Physiotherapy

Intervention Type OTHER

In conventionel physiotherapy, patients will be given posture exercises for balance and strengthening.

Interventions

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Dual Task Training

In dual task training, patients will be given cognitive exercises such as counting backwards from 100 by 3, counting the names of cities, girls and boys while walking.

Intervention Type OTHER

Cognitive Rehabilitation

In cognitive rehabilitation, patients will be given paper-and-pencil activities and exercises to find the difference between two pictures.

Intervention Type OTHER

Conventionel Physiotherapy

In conventionel physiotherapy, patients will be given posture exercises for balance and strengthening.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Definite MS diagnosis by a neurologist
* Can walk independently
* Expanded Disability Status Scale (EDSS) score below 5
* Has not had an attack in the last 3 months, has been medically stable for 6 months
* Has not received a regular physiotherapy program in the last 6 months volunteer

Exclusion Criteria

* Scoring 26 or below on the Montreal Cognitive Assessment Scale (MoCA)
* Having systemic, orthopedic and neurological problems that may affect walking and balance in the assessments
* Having additional psychiatric disorders
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Toros University

OTHER

Sponsor Role lead

Responsible Party

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Aysun Katmerlikaya

Research Assistant

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Aysun Katmerlikaya, MSc

Role: PRINCIPAL_INVESTIGATOR

Toros University

Öznur Tunca, Prof.Dr.

Role: STUDY_DIRECTOR

Hacettepe University

Serhan Sevim, Prof.Dr.

Role: STUDY_CHAIR

Mersin University

Yeliz Salcı, Assoc.Prof.

Role: STUDY_CHAIR

Hacettepe University

Dilek Hande Esen, PhD

Role: STUDY_CHAIR

Toros University

Locations

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Mersin University

Mersin, , Turkey (Türkiye)

Site Status RECRUITING

Countries

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Turkey (Türkiye)

Central Contacts

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Aysun Katmerlikaya, MSc

Role: CONTACT

Öznur Tunca, MSc

Role: CONTACT

03123051080

Facility Contacts

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Aysun Katmerlikaya, MSc

Role: primary

Öznur Tunca, Prof. Dr.

Role: backup

References

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Ozkul C, Guclu-Gunduz A, Eldemir K, Apaydin Y, Gulsen C, Yazici G, Soke F, Irkec C. Dual-Task Cost and Related Clinical Features in Patients With Multiple Sclerosis. Motor Control. 2021 Jan 12;25(2):211-233. doi: 10.1123/mc.2020-0035.

Reference Type BACKGROUND
PMID: 33440347 (View on PubMed)

Abasiyanik Z, Kahraman T. Effect of dual-task training on cognitive functions in persons with multiple sclerosis: A systematic review and meta-analysis. Mult Scler Relat Disord. 2022 Jun;62:103801. doi: 10.1016/j.msard.2022.103801. Epub 2022 Apr 10.

Reference Type RESULT
PMID: 35430546 (View on PubMed)

Related Links

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https://pubmed.ncbi.nlm.nih.gov/35430546/

Effect of dual-task training on cognitive functions in persons with multiple sclerosis: A systematic review and meta-analysis

https://pubmed.ncbi.nlm.nih.gov/33440347/

Dual-Task Cost and Related Clinical Features in Patients With Multiple Sclerosis

Other Identifiers

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TU-FTR-AK-01

Identifier Type: -

Identifier Source: org_study_id

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