Acostream Use in Patients With High Risk and Intermediate-risk Acute Pulmonary Embolism
NCT ID: NCT06946732
Last Updated: 2025-04-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
127 participants
INTERVENTIONAL
2025-04-01
2026-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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The Acostream aspiration group
The pulmonary thrombus removal by Acostream.
Acostream aspiration
The pulmonary thrombus removal by Acostream.
Interventions
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Acostream aspiration
The pulmonary thrombus removal by Acostream.
Eligibility Criteria
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Inclusion Criteria
* Clinical symptoms and presentation consistent with pulmonary embolism (PE).
* PE symptoms duration ≤ 14 days.
* High risk PE patients with absolute contraindications to systemic thrombolysis or its failure (refractory circulatory collapse) not eligible for surgical embolectomy.
* Intermediate-high risk PE patients with right ventricle dysfunction (right ventricle/ left ventricle \>0.9) confirmed by computed tomography pulmonary angiography or transthoracic echocardiography.
Exclusion Criteria
* Refusal to sign the informed consent form.
* Presence of intracardiac thrombus.
* Presence of chronic left heart failure with an ejection fraction lower than 30% Diagnosed thrombophilia.
* History of severe or chronic pulmonary hypertension.
* Serum creatinine level higher than 1.8 mg/dl.
* Known serious and uncontrolled sensitivity to radiographic agents.
18 Years
85 Years
ALL
No
Sponsors
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Xiamen Cardiovascular Hospital, Xiamen University
OTHER
Nantong University Affiliated Hospital
UNKNOWN
Chengdu University of Traditional Chinese Medicine
OTHER
Shanghai No.1 Hospital
UNKNOWN
First Affiliated Hospital of Fujian Medical University
OTHER
Jinhua Central Hospital
OTHER
RenJi Hospital
OTHER
Responsible Party
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Locations
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Renji Hospital
Shanghai, Shanghai Municipality, China
Countries
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Central Contacts
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Facility Contacts
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Role: primary
Other Identifiers
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The ARTIST study
Identifier Type: -
Identifier Source: org_study_id
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