Correlation Study Between the Classification of Arthrogenic Motor Inhibition (AMI) and Clinical Assessment After ACL Rupture

NCT ID: NCT06945133

Last Updated: 2025-11-19

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 90 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-12-01
• Study Completion Date: 2026-12-31

Brief Summary

The goal of this interventional study is to measure medial vastus inhibition and associate it with AMI classification in patients with ACL rupture. The main question it aims to answer is:

Is there a correlation between AMI classification and clinical assessment after ACL rupture ? Participants will undergo surface EMG and Myotonometry.

Conditions

ACL - Anterior Cruciate Ligament Rupture

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

AMI testing group

Interventions administered are the following :

• Surface EMG to measure inhibition of the VM and the RF on the injured and non-injured sides during attempts at voluntary contractions of the knee extensor muscles.
• Myotonometry to measure the stiffness of the semi-membranosus and biceps femoris (long head) on the injured and non-injured sides under resting conditions

Group Type: EXPERIMENTAL

Clinical testing

Intervention Type: OTHER

Intervention includes :

• Surface EMG to measure inhibition of the VM and the rectus femoris (RF) on the injured and non-injured sides during attempts at voluntary contractions of the knee extensor muscles.
• Myotonometry to measure the stiffness of the semimembranosus and biceps femoris (long head) on the injured and non-injured sides under resting conditions

Interventions

Clinical testing

Intervention includes :

• Surface EMG to measure inhibition of the VM and the rectus femoris (RF) on the injured and non-injured sides during attempts at voluntary contractions of the knee extensor muscles.
• Myotonometry to measure the stiffness of the semimembranosus and biceps femoris (long head) on the injured and non-injured sides under resting conditions

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Patient, male or female, aged ≥ 18 years and < 45 years
• Patient with an ACL rupture confirmed by MRI
• Patient with an ACL rupture ≤ 30 days old
• French speaking patient who does not object to the use of his/her data

Exclusion Criteria

• Patient with previous ipsi or contralateral knee injury/surgery
• Patient with multi-ligament injury
• Pregnant or breastfeeding woman

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 44 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

GCS Ramsay Santé pour l'Enseignement et la Recherche

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Hôpital Privé Jean Mermoz

Lyon, , France

Countries

France

Central Contacts

Bertrand SONNERY-COTTET, MD,PhD

Role: CONTACT

sonnerycottet@aol.com

+33 4 37 53 00 22

Facility Contacts

Bertrand SONNERY-COTTET, MD, PhD

Role: primary

sonnerycottet@aol.com

+33 4 37 53 00 22

Other Identifiers

2025-A00125-44

Identifier Type: OTHER

Identifier Source: secondary_id

2025-A00125-44

Identifier Type: -

Identifier Source: org_study_id