Randomized Controlled Trial of the Effects of Combined Resistance and AerobiC Exercise on Health-related Quality of Life in Patients Undergoing First-line Chemotherapy for Metastatic Colorectal Cancer (REACH)
NCT ID: NCT06938971
Last Updated: 2025-07-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
150 participants
INTERVENTIONAL
2025-05-16
2030-05-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
NONE
Study Groups
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Control
Participants allocated to the control group will receive standard care. No restrictions regarding physical activity will be imposed.
No interventions assigned to this group
Exercise training
Participants allocated to the exercise intervention group will receive standard care plus an exercise intervention. The exercise intervention will of consist moderate-to-high intensity supervised and unsupervised home-based exercise training (bicyling, walking, or running) 5 times/week for 18 weeks.
Exercise training
Participants allocated to the exercise intervention group will receive standard care plus an exercise intervention. The exercise intervention will consist moderate-to-high intensity supervised and unsupervised home-based exercise training (bicyling, walking, or running) 5 times/week for 18 weeks.
Interventions
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Exercise training
Participants allocated to the exercise intervention group will receive standard care plus an exercise intervention. The exercise intervention will consist moderate-to-high intensity supervised and unsupervised home-based exercise training (bicyling, walking, or running) 5 times/week for 18 weeks.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* A life expectancy of \< 6 months.
* Absolute contraindications to maximal exercise, as per the recommendations by the Danish Society of Cardiology.
* ECOG (Eastern Cooperative Oncology Group) performance status \> 2.
* Inability to understand the Danish or English language.
* Engagement in structured moderate-to-high aerobic exercise training for \>30 min \>1 times/week for the past 3 months at the time of inclusion.
18 Years
ALL
No
Sponsors
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Rigshospitalet, Denmark
OTHER
Responsible Party
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Casper Simonsen
Group Leader
Locations
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Centre for Physical Activity Research, Copenhagen Univerisity Hospital - Rigshospitalet
Copenhagen, , Denmark
Herlev and Gentofte Hospital
Herlev, , Denmark
North Zealand University Hospital, Hillerød
Hillerød, , Denmark
Zealand University Hospital, Roskilde
Roskilde, , Denmark
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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Exercise mCRC
Identifier Type: -
Identifier Source: org_study_id
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