Effect of Preoperative Chemoradiotherapy on Exercise Capacity as Measured by Cardiopulmonary Exercise Testing

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-01-31

Study Completion Date

2011-10-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study will investigate the effect of preoperative chemoradiotherapy on exercise capacity as measured by cardiopulmonary exercise testing in patients with colorectal cancer.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Assessment of Fitness After Neoadjuvant Chemoradiotherapy in Rectal Cancer Patients

NCT01334593

Cancer

COMPLETED

Prehabilitation During Neoadjuvant Chemoradiotherapy for Rectal Cancer

NCT06542354

Rectal Cancer

COMPLETED NA

The Effects of a 9 Week Exercise Programme on Fitness and Quality of Life in Rectal Cancer Patients After Chemoradiotherapy and Before Surgery

NCT01914068

Rectal Cancer

COMPLETED NA

An Exploratory Study of Sequential Transarterial Chemoembolization With Lipiodol and Neoadjuvant Chemotherapy in the Treatment of Initial Unresectable Colorectal Cancer (CRC)

NCT05340231

Colorectal Cancer

NOT_YET_RECRUITING PHASE2

Avoiding Surgery in Rectal Cancer After Pre-Operative Therapy

NCT01047969

Rectal Adenocarcinoma

UNKNOWN PHASE2

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Chemoradiotherapy is associated with adverse effects. Patients with certain colorectal cancers undergo chemoradiotherapy prior to surgical resection. We intend to assess patient exercise capacity before and after chemoradiotherapy to assess whether this deteriorates. If there is a deleterious effect, this may affect operative outcome.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Colorectal Cancer

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Test arm

Patients undergoing preoperative chemoradiotherapy will have their exercise capacity measured before and after chemoradiotherapy.

Group Type EXPERIMENTAL

Cardiopulmonary exercise testing

Intervention Type OTHER

Cardiopulmonary exercise testing involves cycling on an exercise bicycle whilst oxygen consumption and carbon dioxide generation are measured from expired gases. This is used to calculate patient fitness from their peak oxygen consumption and their anaerobic threshold.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Cardiopulmonary exercise testing

Cardiopulmonary exercise testing involves cycling on an exercise bicycle whilst oxygen consumption and carbon dioxide generation are measured from expired gases. This is used to calculate patient fitness from their peak oxygen consumption and their anaerobic threshold.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Age greater than 65
* Colorectal cancer requiring preoperative chemoradiotherapy

Exclusion Criteria

* Inability to walk, or exercise on a bicycle or treadmill
* Inability to understand instructions for CPET testing
* ASA grade 4 or 5 (indicating severe cardiovascular co-morbidity and not expected to survive surgery)
* Contraindications to Exercise Testing
* Myocardial infarction occurring 10 days or less before CPX testing
* Symptomatic arrythmias
* Left Main Stem coronary disease of \>50%
* Severe hypertension (SBP\>180mmHg)
* Resting SpO2 \<85%
* Acute cardiac inflammatory conditions (myocarditis, pericarditis)
* Unstable angina with symptoms within 4 days
* Dissecting aneurysm of aorta
* Acute pyrexial illness
* Thyrotoxicosis
* Syncopal episodes
* Lower limb thrombosis (arterial or venous)

Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No