the Effect of Hyaluronic Acid Intrauterine Wash on Endometrial Receptivity and Pregnancy Outcome

NCT ID: NCT06937645

Last Updated: 2025-04-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE2

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-09-01

Study Completion Date

2025-08-01

Brief Summary

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Hyaluronic acid intrauterine wash is done for infertile females undergoing intracytoplasmic sperm injection on the day of oocyte retrieval. endometrial receptivity parameters, including the subendometrial vasculature indices were measured before and after the intervention for purpose of studying the effect of hyaluronic acid on improvement of the endometrial receptivity and subsequently the pregnancy outcome

Detailed Description

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Conditions

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Infertile Patients

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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the uterine cavity washed with hyaluronic acid preparation on the day of ooc

40 infertile patients had their uterine cavity with hyaluronic acid preparation on the day of oocytes retrieval in ICSI

Group Type EXPERIMENTAL

Hyaluronic Acid (HA)

Intervention Type DRUG

hyaluronic acid PRP preparation used to wash the endometrium on the day of oocytes retrieval

40 infertile females had their uterine cavity washed with PRP preparation

40 infertile females had their uterine cavity washed with PRP preparation on the day of oocytes retrieval in ICSI

Group Type EXPERIMENTAL

platlet rich plasma (PRP)

Intervention Type DRUG

PRP preparation used to wash the uterine cavity on the day of oocytes retrieval

40 infertile females with no intervention for their uterus

40 infertile females with no intervention for their uterus on the day of oocytes retrieval in ICSI

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Hyaluronic Acid (HA)

hyaluronic acid PRP preparation used to wash the endometrium on the day of oocytes retrieval

Intervention Type DRUG

platlet rich plasma (PRP)

PRP preparation used to wash the uterine cavity on the day of oocytes retrieval

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Infertile females aged 18-40 years.
* Infertile females scheduled for GnRH antagonist protocol of fresh ICSI cycle.
* Females use dual stimulation (GnRH agonist plus Ovetrelle) for ovulation triggering.

Exclusion Criteria

* Infertile females diagnosed as a poor responder.
* Infertile females diagnosed with uterine pathology.
* Infertile females who are scheduled for a frozen ICSI cycle.
* Infertile females diagnosed with endocrine diseases like thyroid disease, diabetes mellitus, and hyperprolactinemia.
* Infertile females diagnosed with thrombocytopenia.
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Al-Nahrain University

OTHER

Sponsor Role lead

Responsible Party

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ghada bassim raaf

clinical professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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high institute for infertility diagnosis and ARTS

AL-Kadimya, Baghdad Governorate, Iraq

Site Status RECRUITING

Countries

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Iraq

Central Contacts

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ghada bassim raaf, Ph.D.

Role: CONTACT

+9647714728261

lubna alanbari, Ph.D.

Role: CONTACT

07729420158

Facility Contacts

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Lubna Amer Al anbari, Ph.D.

Role: primary

00964 7729420158

Other Identifiers

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0701-PF-2023G12

Identifier Type: -

Identifier Source: org_study_id

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