A Pilot Feasibility and Acceptability Study of Remote ExerciSe Training mOdalities (PRESTO)

NCT ID: NCT06931470

Last Updated: 2025-04-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-04-06

Study Completion Date

2026-12-01

Brief Summary

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This study will investigate the acceptability and efficacy of 12 weeks of: Smart-device app-based (MyZone) Asynchronous Virtual, Synchronous Virtual, and in-person aerobic training in individuals at risk for Cardiovascular Disease (CVD) who do are not meeting American Heart Association (AHA) guidelines for physical activity. The study aims to 1) Assess the effect of several approaches to remote aerobic training on measures of physical activity, cardiovascular fitness and CVD risk, and 2) Quantitatively and qualitatively evaluate exercise training program fidelity, implementation, effectiveness, and remaining barriers to acceptance.

Participants will be asked to undergo Cardiopulmonary Exercise Testing (CPET) before and after 12-weeks of training via one of the 4 modalities (random assignment) listed above. They will respond to questions regarding acceptability of the interventions.

Detailed Description

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Conditions

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Cardiovascular Diseases

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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In-Person Supervised Aerobic Exercise Intervention (IPSAEI)

Participants engage in supervised exercise sessions at a facility, where trainers use centralized telemetry to monitor heart rates and provide immediate feedback and adjustments to exercise intensity.

Group Type ACTIVE_COMPARATOR

In-person supervised exercise sessions

Intervention Type BEHAVIORAL

Gold-standard, facility-based sessions (3 sessions/week) with an onsite trainer guidance with an exercise Intensity of 40-80% heart rate reserve (HRR) or Rate of Perceived Exertion (RPE) 12-16.

Centralized telemetry

Intervention Type DEVICE

Centralized telemetry monitors heart rates and provides immediate feedback for trainers to adjust exercise intensity.

Remote Synchronous Aerobic Exercise Intervention (RSAEI)

Participants join live-streamed exercise sessions led by a virtual trainer. Real-time heart rate monitoring via an app allows the trainer to provide immediate feedback and adjust exercise intensity as needed.

Group Type EXPERIMENTAL

Virtual classes (live-streamed sessions)

Intervention Type BEHAVIORAL

Live-streamed exercise classes (3 sessions/week) with a trainer providing real-time feedback.

Map My Fitness mobile application

Intervention Type DEVICE

Participants will wear a Bluetooth-compatible heart rate monitor (e.g., apple watch/fitbit) that syncs with MapMyFitness. MapMyFitness automatically records workout sessions (duration, distance, heart rate, calories burned, and elevation gain where applicable).

Asynchronous Remote Aerobic Exercise Intervention (RASAEI)

Participants exercise independently while monitoring their heart rate in real time using the Map My Fitness app. They adjust their intensity based on personal targets and receive periodic feedback from a trainer during scheduled check-ins.

Group Type EXPERIMENTAL

Self-directed aerobic exercise

Intervention Type BEHAVIORAL

Participants exercise independently and follow a weekly progression plan (3-5 sessions/week (depending on the specific progression)).

Map My Fitness mobile application

Intervention Type DEVICE

Participants will wear a Bluetooth-compatible heart rate monitor (e.g., apple watch/fitbit) that syncs with MapMyFitness. MapMyFitness automatically records workout sessions (duration, distance, heart rate, calories burned, and elevation gain where applicable).

Remote MyZone Aerobic Exercise Intervention (RMZAEI)

Participants use the Myzone heart rate monitor and app to receive real-time feedback on their exercise intensity. The Myzone platform provides automated guidance on intensity adjustments, goal setting, and motivational support through features like challenges and social connectivity.

Group Type EXPERIMENTAL

Myzone mobile application

Intervention Type DEVICE

Training using the Myzone platform, with participants wearing the Myzone heart rate monitor and using the Myzone app to receive real-time feedback and guidance during exercise sessions (3 days per week). Myzone integrates with its proprietary wearable devices to monitor heart rate and other activity metrics, providing real-time data to users via the app.

Myzone heart rate monitor

Intervention Type DEVICE

Wearable device (chest strap or armband) that monitors heart rate.

Interventions

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In-person supervised exercise sessions

Gold-standard, facility-based sessions (3 sessions/week) with an onsite trainer guidance with an exercise Intensity of 40-80% heart rate reserve (HRR) or Rate of Perceived Exertion (RPE) 12-16.

Intervention Type BEHAVIORAL

Virtual classes (live-streamed sessions)

Live-streamed exercise classes (3 sessions/week) with a trainer providing real-time feedback.

Intervention Type BEHAVIORAL

Self-directed aerobic exercise

Participants exercise independently and follow a weekly progression plan (3-5 sessions/week (depending on the specific progression)).

Intervention Type BEHAVIORAL

Myzone mobile application

Training using the Myzone platform, with participants wearing the Myzone heart rate monitor and using the Myzone app to receive real-time feedback and guidance during exercise sessions (3 days per week). Myzone integrates with its proprietary wearable devices to monitor heart rate and other activity metrics, providing real-time data to users via the app.

Intervention Type DEVICE

Map My Fitness mobile application

Participants will wear a Bluetooth-compatible heart rate monitor (e.g., apple watch/fitbit) that syncs with MapMyFitness. MapMyFitness automatically records workout sessions (duration, distance, heart rate, calories burned, and elevation gain where applicable).

Intervention Type DEVICE

Centralized telemetry

Centralized telemetry monitors heart rates and provides immediate feedback for trainers to adjust exercise intensity.

Intervention Type DEVICE

Myzone heart rate monitor

Wearable device (chest strap or armband) that monitors heart rate.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. \>45 years
2. At risk for CVD (participants must have one or more of the following risk factors: hypertension, hyperlipidemia, Type 2 Diabetes Mellitus, smoking, obesity, family history of premature CVD)
3. Not meeting AHA physical activity guidelines for at least 3 months prior to screening

* Hypertension:

* Systolic BP ≥140 mm Hg and/or diastolic BP ≥90 mm Hg and/or
* Use of anti-hypertensive medication
* Hyper / dyslipidemia

* LDL cholesterol levels ≥160 mg/dL and/or
* HDL cholesterol \<50mg/dL for women, \<40mg/dL for women, in addition to fasting triglycerides \>150mg/dL
* Diabetes Mellitus:

* Hemoglobin A1c levels ≥6.5%, fasting glucose levels ≥126 mg/dL, or 2-hour glucose levels ≥200 mg/dL after an oral glucose tolerance test and/or
* Use of any diabetes medication
* Smoking:

o Current regular tobacco use.
* Obesity:

o BMI ≥30 kg/m².
* Family History of Premature Cardiovascular Disease:

* Having a first-degree relative (parent, sibling) who developed CVD before age 55 for biological males or age 65 for biological females.

Exclusion Criteria

1. Established diagnosis of atherosclerotic CVD
2. Presence of any serious medical conditions that would not allow safe participation in exercise according to the American College of Sports Medicine (ACSM) and the AHA (56-58)
3. Pregnant or anticipating pregnancy
4. Plan to be away for \>2 weeks during the intervention period
5. Presence of any biopsychosocial factors that the principal investigator deems as having significant potential to interfere with effective study participation
Minimum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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NYU Langone Health

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Sean P. Heffron, MD

Role: PRINCIPAL_INVESTIGATOR

NYU Langone Health

Locations

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NYU Langone Health

New York, New York, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Alec Sinatro, MD

Role: CONTACT

914-571-9575

Sean Heffron, MD

Role: CONTACT

857-366-1417

Other Identifiers

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24-01067

Identifier Type: -

Identifier Source: org_study_id

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