Thyroid Cancer in Surgical Treated Multinodular Goiter

NCT ID: NCT06924242

Last Updated: 2025-04-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

223 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-01-01

Study Completion Date

2024-07-31

Brief Summary

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This study aims to investigate, based on existing knowledge, the incidence of occult thyroid carcinoma in a cohort of patients with MNG, providing new insights into the prevalence and characteristics of thyroid malignancies in MNG. It seeks to contribute to optimizing diagnostic evaluations for patients with multinodular goiter.

Detailed Description

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This retrospective study included patients with a preoperative diagnosis of multinodular goiter who underwent total or partial thyroidectomy from January 2018 to May 2024 at the Department of Medical and Surgical Sciences at the University Hospital "Ospedali Riuniti" in Foggia. The study's objective was to investigate the incidence of thyroid carcinoma in patients undergoing thyroidectomy for MNG, also analyzing associated demographic and clinical variables.

Conditions

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Goiter, Nodular Total Thyroidectomy Thyroid Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Patient with multinodular goiter who underwent total or partial thyroidectomy

total or partial thyroidectomy

Intervention Type PROCEDURE

Total thyroidectomy is a surgical procedure that involves the complete removal of the thyroid gland. It is performed to treat conditions such as thyroid cancer, large goiters, or severe hyperthyroidism. The surgery is typically conducted under general anesthesia through an incision in the lower neck. Postoperative management may include hormone replacement therapy with levothyroxine to compensate for the loss of thyroid function. Potential complications include hypocalcemia due to parathyroid gland injury and vocal cord dysfunction from recurrent laryngeal nerve damage.

Interventions

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total or partial thyroidectomy

Total thyroidectomy is a surgical procedure that involves the complete removal of the thyroid gland. It is performed to treat conditions such as thyroid cancer, large goiters, or severe hyperthyroidism. The surgery is typically conducted under general anesthesia through an incision in the lower neck. Postoperative management may include hormone replacement therapy with levothyroxine to compensate for the loss of thyroid function. Potential complications include hypocalcemia due to parathyroid gland injury and vocal cord dysfunction from recurrent laryngeal nerve damage.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* patients diagnosed with multinodular goiter via thyroid ultrasound, with or without FNA cytology.
* patients who underwent surgery.
* availability of complete clinical data

Exclusion Criteria

* history of thyroid carcinoma or other thyroid neoplasms.
* not completed postoperative follow up.
* patients with preoperative FNA results indicating malignancy (TIR 4-5), suspicion of malignancy (TIR 3), or indeterminate significance (TIR 1)
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Foggia

OTHER

Sponsor Role lead

Responsible Party

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Giovanna Pavone

Medical Doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University of Foggia

Foggia, FG, Italy

Site Status

Countries

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Italy

Provided Documents

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Document Type: Study Protocol

View Document

Other Identifiers

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10

Identifier Type: -

Identifier Source: org_study_id

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