Enteric-Coated Peppermint Oil Versus Standard Antispasmodic in SLC6A4 (5-HTTLPR) Carriers With Irritable Bowel Syndrome.

NCT ID: NCT06914921

Last Updated: 2025-04-23

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 224 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-02-04
• Study Completion Date: 2025-02-01

Brief Summary

This study is a non-inferiority, double-blind, randomized controlled trial comparing enteric-coated peppermint oil with a standard antispasmodic (e.g., mebeverine) in adult IBS patients who carry at least one "S" allele in the SLC6A4 (5-HTTLPR) polymorphism. The primary goal is to see whether peppermint oil provides symptom relief (measured by IBS severity scores) that is not worse than the antispasmodic by more than a predefined margin (30 points on the IBS-SSS). Secondary goals include evaluating differences in abdominal pain, stool patterns, quality of life, and adverse event profiles, with a focus on peppermint oil's tolerability. About 224 participants (112 per arm) will be enrolled, with allowances for dropout, to detect non-inferiority at 80% power. After 12 weeks of treatment, results will inform whether peppermint oil is a viable, well-tolerated alternative to standard antispasmodics, especially in patients with heightened GI sensitivity linked to the SLC6A4 polymorphism.

Detailed Description

This double-blind, parallel-group, non-inferiority RCT will randomize ~250 adults (18-65 y) who meet Rome IV criteria for IBS and carry at least one short 5-HTTLPR (SLC6A4) allele to enteric-coated peppermint-oil capsules (180 mg three times daily) or the standard antispasmodic mebeverine (135 mg three times daily) for 12 weeks. Because the S-allele reduces serotonin-transporter expression and heightens visceral sensitivity, the study targets a genetically defined subgroup in which menthol's smooth-muscle-relaxing calcium-channel blockade may yield clinically meaningful benefit with fewer anticholinergic effects. Randomisation (1 : 1) is web-based, stratified by genotype and centre, and treatments are packaged identically to maintain blinding of participants, investigators, and outcome assessors. The primary endpoint is change from baseline in the IBS Severity Scoring System at week 12; non-inferiority is met if the upper bound of the two-sided 95 % CI for the treatment difference (peppermint - mebeverine) is ≤ +30 points. A mixed-model repeated-measures analysis will be applied to both intention-to-treat and per-protocol populations, providing 80 % power with ~112 evaluable patients per arm. Secondary outcomes include abdominal-pain intensity, stool form, quality of life, global satisfaction, and adverse events; safety is tracked via weekly contacts, laboratory tests, and an independent data-safety monitoring board. Demonstrating that peppermint oil is at least as effective as mebeverine while better tolerated would support its use as a genotype-guided first-line therapy for IBS.

Conditions

Irritable Bowel Syndrome (IBS)

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: TRIPLE

Study Groups

Enteric-coated peppermint oil capsules (~180 mg total peppermint oil/ capsule) to ensure release in

Group Type: EXPERIMENTAL

Peppermint Oil

Intervention Type: DIETARY_SUPPLEMENT

Enteric-coated peppermint oil capsules (~180 mg total peppermint oil/ capsule) to ensure release in the small intestine.

1 capsule three times daily, 30 minutes before meals, for 12 weeks.

A standard antispasmodiс

A standard antispasmodic (e.g., mebeverine 135 mg).

Group Type: ACTIVE_COMPARATOR

A standard antispasmodic

Intervention Type: DRUG

A standard antispasmodic (e.g., mebeverine 135 mg). 1 tablet three times daily, before meals, for 12 weeks.

Interventions

Peppermint Oil

Enteric-coated peppermint oil capsules (~180 mg total peppermint oil/ capsule) to ensure release in the small intestine.

1 capsule three times daily, 30 minutes before meals, for 12 weeks.

Intervention Type: DIETARY_SUPPLEMENT

A standard antispasmodic

A standard antispasmodic (e.g., mebeverine 135 mg). 1 tablet three times daily, before meals, for 12 weeks.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Adults aged 18-65 years.
• Diagnosis of Irritable Bowel Syndrome by Rome IV criteria, with at least moderate severity (IBS-SSS ≥ 175).
• SLC6A4 genotyping confirms at least one S allele (SS or SL).
• Able and willing to provide informed consent and comply with study procedures.

Exclusion Criteria

• L/L genotype of 5-HTTLPR.
• Known organic GI diseases (e.g., IBD, celiac disease).
• Severe/unstable comorbidities (e.g., cardiac, hepatic, or renal dysfunction).
• Use of peppermint oil, antispasmodics, or investigational drugs within 30 days prior to enrollment.
• . Known hypersensitivity to peppermint or mebeverine.
• Pregnancy or breastfeeding.
• Significant psychiatric illness that, in the investigator's judgment, might interfere with participation.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Center for New Medical Technologies, Novosibirsk, Russia

OTHER

Sponsor Role: collaborator

S.LAB (SOLOWAYS)

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Center for New Medical Technologirs

Novosibirsk, , Russia

Countries

Russia

Other Identifiers

SW027

Identifier Type: -

Identifier Source: org_study_id