Effects of Open-label vs Double-blind Treatment in IBS

NCT ID: NCT02802241

Last Updated: 2024-01-22

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

340 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-06-30

Study Completion Date

2019-01-31

Brief Summary

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The purpose of this study is to investigate placebo effects and peppermint oil in Irritable Bowel Syndrome.

Detailed Description

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Conditions

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Irritable Bowel Syndrome Placebo Effect Placebos Peppermint Oil

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Study Groups

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open-label placebo

Group Type EXPERIMENTAL

placebo

Intervention Type DRUG

double-blind placebo

Group Type EXPERIMENTAL

placebo

Intervention Type DRUG

double-blind peppermint oil

Group Type EXPERIMENTAL

peppermint oil

Intervention Type DIETARY_SUPPLEMENT

no additional treatment

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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placebo

Intervention Type DRUG

peppermint oil

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Meet Rome IV diagnostic criteria for IBS
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Center for Complementary and Integrative Health (NCCIH)

NIH

Sponsor Role collaborator

Beth Israel Deaconess Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Judy Nee

Assistant Professor of Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States

Site Status

Countries

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United States

References

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Lembo A, Kelley JM, Nee J, Ballou S, Iturrino J, Cheng V, Rangan V, Katon J, Hirsch W, Kirsch I, Hall K, Davis RB, Kaptchuk TJ. Open-label placebo vs double-blind placebo for irritable bowel syndrome: a randomized clinical trial. Pain. 2021 Sep 1;162(9):2428-2435. doi: 10.1097/j.pain.0000000000002234.

Reference Type DERIVED
PMID: 33605656 (View on PubMed)

Ballou S, Kaptchuk TJ, Hirsch W, Nee J, Iturrino J, Hall KT, Kelley JM, Cheng V, Kirsch I, Jacobson E, Conboy L, Lembo A, Davis RB. Open-label versus double-blind placebo treatment in irritable bowel syndrome: study protocol for a randomized controlled trial. Trials. 2017 May 25;18(1):234. doi: 10.1186/s13063-017-1964-x.

Reference Type DERIVED
PMID: 28545508 (View on PubMed)

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

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R01AT008573

Identifier Type: NIH

Identifier Source: secondary_id

View Link

2015P000282

Identifier Type: -

Identifier Source: org_study_id

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