Underprescribing in Geriatric Patients: a Prevalence Study and Analysis of Factors Contributing to Potential Prescription Omissions (Under-PRES)

NCT ID: NCT06904638

Last Updated: 2025-04-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

374 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-06-20

Study Completion Date

2026-12-31

Brief Summary

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This observational study will determine the prevalence of underprescription in a cohort of elderly patients, recruited at the time of an outpatient geriatric visit, or hospitalized, upon admission to a geriatric ward.

Detailed Description

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Polypharmacy in older patients is associated with both inappropriate drug prescribing and underprescription or omission of appropriate medications. Potential prescriptive omission (PPO), defined as the underprescription of potentially beneficial drugs, is increasing across all care settings and is associated with adverse clinical outcomes. However, in some cases, PPO may represent a legitimate medical decision.

The aim of this study is to investigate the phenomenon of underprescription by differentiating between justified and inappropriate potential prescriptive omissions (PPOs) in elderly patients in both hospital and outpatient settings, using the Screening Tool to Alert to Right Treatment (START) criteria, version 3.

Conditions

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Older People

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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older adults

Geriatric patients admitted to a geriatric hospital unit or attending an outpatient geriatric clinic

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Geriatric ward admission or outpatient geriatric appointment
* Capacity to provide informed consent by the patient or legal guardian

Exclusion Criteria

* Limited life expectancy as measured by the Clinical Frailty Scale (CFS) \>8
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Istituto Nazionale di Ricovero e Cura per Anziani

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Antonio Cherubini, MD

Role: STUDY_CHAIR

IRCCS INRCA, Ancona, Italy

Locations

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IRCCS INRCA Hospital

Ancona, , Italy

Site Status RECRUITING

IRCCS INRCA Hospital

Cosenza, , Italy

Site Status RECRUITING

Countries

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Italy

Central Contacts

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Anna Rita Bonfigli

Role: CONTACT

0718003719

Facility Contacts

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Alessia Beccacece, PhD

Role: primary

Luca Soraci, MD

Role: primary

Other Identifiers

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INRCA_004_2025

Identifier Type: -

Identifier Source: org_study_id

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